Taro (Colocasia Esculenta (L.) Schott) Extract didn’t Increase Superoxide Dismutase (SOD) but Decrease C-Reactive Protein (CRP) in Male Wistar Rat (Rattus Norvegicus) Diabetes Mellitus Model Article Swipe

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Demak Vera Rachelia , Gde Ngurah Indraguna Pinatih , Ni Nyoman Ayu Dewi ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.47119/ijrp1001051720223640

Backgrounds: In hyperglycemia induced by streptozotocin, free radicals and oxidative stress conditions occur. This also reduced SOD enzymes while increasing CRP. This study aimed to analyze effect of flavonoid-rich taro leaves ethanol extract on SOD levels and serum CRP levels in rats diabetes melitus model induced by streptozotocin. Methods: Experimental study with a pretest-posttest control group design 26 healthy rats were randomly divided into 2 groups. The control group was given 2 ml aquadest and treatment group was given 400mg/kgBW ethanol extract of taro leaves in 2 ml aquadest. Before and after treatment, blood serum was collected for SOD and CRP analysis using the ELISA technique. Results: SOD level in control goup before and after given plasebo were reduce insignificantly (from 5.37?0.69 ng/ml to 5.26?1.50 ng/ml ;p = 0.830). Furthermore, CRP level in control group before and after given plasebo were not signifcantly different (from 3.39?0.24 ng/ml to 3.56 ?0.43 ng/ml ; p = 0.308). SOD level in treatment group before and after given taro extract were increase but not significant (from 5.33 ?1.14 ng/ml to 6.20 ?2.64 ng/mL; p = 0.239). However, CRP level in control group after given plasebo decrease significantly (from 3.56 ? 0.43 ng/mL to 2.93 ? 0.47 nmol/mL ; p = 0.009).Conclusion: ethanol extract of taro leaves did not increase SOD levels but decrease CRP levels in rats model diabetes melitus induced by streptozotocin. Further studies are needed to confirm extract of taro leaves as external antioxidant.

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Streptozotocin Superoxide dismutase Colocasia esculenta Traditional medicine Oxidative stress Negative control Diabetes mellitus Positive control Ethanol Chemistry Flavonoid Medicine Antioxidant Internal medicine Endocrinology Biochemistry Biology Botany

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Type: article
Language: en
Landing Page: https://doi.org/10.47119/ijrp1001051720223640
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Title: Taro (Colocasia Esculenta (L.) Schott) Extract didn’t Increase Superoxide Dismutase (SOD) but Decrease C-Reactive Protein (CRP) in Male Wistar Rat (Rattus Norvegicus) Diabetes Mellitus Model

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Publication year: 2022

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Publication date: 2022-07-01

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Authors: Demak Vera Rachelia, Gde Ngurah Indraguna Pinatih, Ni Nyoman Ayu Dewi

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Concepts: Streptozotocin, Superoxide dismutase, Colocasia esculenta, Traditional medicine, Oxidative stress, Negative control, Diabetes mellitus, Positive control, Ethanol, Chemistry, Flavonoid, Medicine, Antioxidant, Internal medicine, Endocrinology, Biochemistry, Biology, Botany

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abstract_inverted_index.0.308).	154
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