Taste Masking of Enalapril Maleate by the Precipitation Method Article Swipe
Yana Zh. Georgieva
,
Bissera Pilicheva
,
Vesela Kokova
,
Elisaveta Apostolova
,
Margarita Kassarova
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3897/folmed.61.e39208
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3897/folmed.61.e39208
Background: Taste masking of bitter or unpleasant drugs is an important prerequisite to improve patient compliance, especially for children and elderly patients. We aimed at obtaining taste-masked microparticles intended for incorporation into orodispersible tablets (ODTs). We selected the precipitation method using enalapril maleate (ENA) as a model bitter-tasting drug and Eudragit EPO ® as a pH sensitive polymer. Aim: The aim of this study was to obtain microparticles with enalapril maleate by the precipitation method in order to mask the bitter taste of the drug. Materials and methods: Nine models of enalapril maleate – Eudragit EPO ® microparticles were prepared by the precipitation method at varied drug-polymer ratios. The models were characterized in terms of size, shape, production yield, drug content, encapsulation efficiency and moisture content. Fourier-transformed infrared spectroscopy, powder X-ray diffraction and differential scanning calorimetry were used to analyze possible interactions in the complex. In vitro drug release in simulated salivary fluid and in vivo taste evaluation in rats were realized to prove taste masking. Results: The particle size distribution varied from 266.9 µm to 410.9 µm. The shape of the resulting particles was irregular. The production yield varied from 23.6% to 78.2%. The drug content ranged between 2.3% to 4.8%, encapsulation efficiency increased from 1.6% to 9.0%. In vitro drug release data indicated significant taste masking. Conclusion: Some of the obtained microparticles by the precipitation method showed satisfactory taste masking efficiency, which proved the taste masking feasibility of this method.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3897/folmed.61.e39208
- https://foliamedica.bg/article/39208/download/pdf/
- OA Status
- diamond
- Cited By
- 7
- References
- 9
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2978091292
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2978091292Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3897/folmed.61.e39208Digital Object Identifier
- Title
-
Taste Masking of Enalapril Maleate by the Precipitation MethodWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2019Year of publication
- Publication date
-
2019-09-30Full publication date if available
- Authors
-
Yana Zh. Georgieva, Bissera Pilicheva, Vesela Kokova, Elisaveta Apostolova, Margarita KassarovaList of authors in order
- Landing page
-
https://doi.org/10.3897/folmed.61.e39208Publisher landing page
- PDF URL
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https://foliamedica.bg/article/39208/download/pdf/Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://foliamedica.bg/article/39208/download/pdf/Direct OA link when available
- Concepts
-
Taste, Chemistry, Differential scanning calorimetry, Enalapril, Pharmacology, Particle size, Enalapril Maleate, Chromatography, Bitter taste, Materials science, Food science, Medicine, Internal medicine, Thermodynamics, Angiotensin-converting enzyme, Physical chemistry, Blood pressure, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
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2023: 3, 2022: 2, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
9Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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