Taurine Inhibits Apolipoprotein E4 Aggregation Article Swipe
Anthony Legrand
,
Kateřina Amruz Černá
,
Sérgio M. Marques
,
Naresh K. Verma
,
Jakub Kopko
,
Tereza Váňová
,
Madhumalar Subramanian
,
Benedik Jaroslav
,
Tomas Henek
,
Pavel Vaňáček
,
Josef Kučera
,
Joan Planas-Iglesias
,
Jiří Sedmík
,
Veronika Pospíšilová
,
Petr Kouba
,
Aneta Vaskova
,
Markéta Nezvedová
,
Jiří Sedlář
,
Jiřı́ Damborský
,
Stanislav Mazurenko
,
Martin Marek
,
Josef Šivic
,
Lenka Hernychová
,
David Bednář
,
Dáša Bohačiaková
,
Zbyněk Prokop
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.08.13.669519
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.08.13.669519
Apolipoprotein E4 (ApoE4) is a major genetic risk factor in many neurodegenerative diseases, yet effective therapeutic strategies targeting its associated pathologies remain unresolved. The aggregation of ApoE4, a key pathological feature, can be attenuated by tramiprosate and its metabolite 3-sulfopropanoic acid. In this study, we investigated the potential of taurine, a close chemical analogue of tramiprosate, to modulate ApoE4-mediated pathological processes. Using an integrated approach—including molecular dynamics simulations, static light scattering, mass spectrometry, and cerebral organoid models—we investigated taurine’s effects on ApoE4 aggregation. We found that taurine effectively inhibits ApoE4 aggregation. Notably, taurine significantly ameliorates the pathophysiological characteristics of ApoE4, bringing its phenotype closer to the more benign ApoE3 variant. By leveraging its neuroprotective properties, taurine may offer effects comparable to tramiprosate and 3-sulfopropanoic acid, positioning it as an accessible and promising candidate for mitigating neurodegeneration, particularly in individuals with the high-risk ApoE4/E4 genotype .
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.08.13.669519
- https://www.biorxiv.org/content/biorxiv/early/2025/08/13/2025.08.13.669519.full.pdf
- OA Status
- green
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413128415
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413128415Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.08.13.669519Digital Object Identifier
- Title
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Taurine Inhibits Apolipoprotein E4 AggregationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-08-13Full publication date if available
- Authors
-
Anthony Legrand, Kateřina Amruz Černá, Sérgio M. Marques, Naresh K. Verma, Jakub Kopko, Tereza Váňová, Madhumalar Subramanian, Benedik Jaroslav, Tomas Henek, Pavel Vaňáček, Josef Kučera, Joan Planas-Iglesias, Jiří Sedmík, Veronika Pospíšilová, Petr Kouba, Aneta Vaskova, Markéta Nezvedová, Jiří Sedlář, Jiřı́ Damborský, Stanislav Mazurenko, Martin Marek, Josef Šivic, Lenka Hernychová, David Bednář, Dáša Bohačiaková, Zbyněk ProkopList of authors in order
- Landing page
-
https://doi.org/10.1101/2025.08.13.669519Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2025/08/13/2025.08.13.669519.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2025/08/13/2025.08.13.669519.full.pdfDirect OA link when available
- Concepts
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Taurine, Apolipoprotein B, Chemistry, Biochemistry, Internal medicine, Cholesterol, Medicine, Amino acidTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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54Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.of | 26, 49, 55, 99 |
| abstract_inverted_index.on | 81 |
| abstract_inverted_index.to | 57, 105, 121 |
| abstract_inverted_index.we | 45 |
| abstract_inverted_index.The | 24 |
| abstract_inverted_index.and | 37, 74, 123, 131 |
| abstract_inverted_index.can | 32 |
| abstract_inverted_index.for | 134 |
| abstract_inverted_index.its | 19, 38, 102, 113 |
| abstract_inverted_index.key | 29 |
| abstract_inverted_index.may | 117 |
| abstract_inverted_index.the | 47, 96, 106, 141 |
| abstract_inverted_index.yet | 14 |
| abstract_inverted_index.many | 11 |
| abstract_inverted_index.mass | 72 |
| abstract_inverted_index.more | 107 |
| abstract_inverted_index.risk | 8 |
| abstract_inverted_index.that | 86 |
| abstract_inverted_index.this | 43 |
| abstract_inverted_index.with | 140 |
| abstract_inverted_index.ApoE3 | 109 |
| abstract_inverted_index.ApoE4 | 82, 90 |
| abstract_inverted_index.Using | 62 |
| abstract_inverted_index.acid, | 125 |
| abstract_inverted_index.acid. | 41 |
| abstract_inverted_index.close | 52 |
| abstract_inverted_index.found | 85 |
| abstract_inverted_index.light | 70 |
| abstract_inverted_index.major | 6 |
| abstract_inverted_index.offer | 118 |
| abstract_inverted_index.ApoE4, | 27, 100 |
| abstract_inverted_index.benign | 108 |
| abstract_inverted_index.closer | 104 |
| abstract_inverted_index.factor | 9 |
| abstract_inverted_index.remain | 22 |
| abstract_inverted_index.static | 69 |
| abstract_inverted_index.study, | 44 |
| abstract_inverted_index.(ApoE4) | 3 |
| abstract_inverted_index.effects | 80, 119 |
| abstract_inverted_index.genetic | 7 |
| abstract_inverted_index.taurine | 87, 93, 116 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.ApoE4/E4 | 143 |
| abstract_inverted_index.Notably, | 92 |
| abstract_inverted_index.analogue | 54 |
| abstract_inverted_index.bringing | 101 |
| abstract_inverted_index.cerebral | 75 |
| abstract_inverted_index.chemical | 53 |
| abstract_inverted_index.dynamics | 67 |
| abstract_inverted_index.feature, | 31 |
| abstract_inverted_index.genotype | 144 |
| abstract_inverted_index.inhibits | 89 |
| abstract_inverted_index.modulate | 58 |
| abstract_inverted_index.organoid | 76 |
| abstract_inverted_index.taurine, | 50 |
| abstract_inverted_index.variant. | 110 |
| abstract_inverted_index.candidate | 133 |
| abstract_inverted_index.diseases, | 13 |
| abstract_inverted_index.effective | 15 |
| abstract_inverted_index.high-risk | 142 |
| abstract_inverted_index.molecular | 66 |
| abstract_inverted_index.phenotype | 103 |
| abstract_inverted_index.potential | 48 |
| abstract_inverted_index.promising | 132 |
| abstract_inverted_index.targeting | 18 |
| abstract_inverted_index.accessible | 130 |
| abstract_inverted_index.associated | 20 |
| abstract_inverted_index.attenuated | 34 |
| abstract_inverted_index.comparable | 120 |
| abstract_inverted_index.integrated | 64 |
| abstract_inverted_index.leveraging | 112 |
| abstract_inverted_index.metabolite | 39 |
| abstract_inverted_index.mitigating | 135 |
| abstract_inverted_index.processes. | 61 |
| abstract_inverted_index.strategies | 17 |
| abstract_inverted_index.aggregation | 25 |
| abstract_inverted_index.ameliorates | 95 |
| abstract_inverted_index.effectively | 88 |
| abstract_inverted_index.individuals | 139 |
| abstract_inverted_index.models—we | 77 |
| abstract_inverted_index.pathologies | 21 |
| abstract_inverted_index.positioning | 126 |
| abstract_inverted_index.properties, | 115 |
| abstract_inverted_index.scattering, | 71 |
| abstract_inverted_index.taurine’s | 79 |
| abstract_inverted_index.therapeutic | 16 |
| abstract_inverted_index.unresolved. | 23 |
| abstract_inverted_index.aggregation. | 83, 91 |
| abstract_inverted_index.investigated | 46, 78 |
| abstract_inverted_index.particularly | 137 |
| abstract_inverted_index.pathological | 30, 60 |
| abstract_inverted_index.simulations, | 68 |
| abstract_inverted_index.tramiprosate | 36, 122 |
| abstract_inverted_index.significantly | 94 |
| abstract_inverted_index.spectrometry, | 73 |
| abstract_inverted_index.tramiprosate, | 56 |
| abstract_inverted_index.ApoE4-mediated | 59 |
| abstract_inverted_index.Apolipoprotein | 1 |
| abstract_inverted_index.characteristics | 98 |
| abstract_inverted_index.neuroprotective | 114 |
| abstract_inverted_index.3-sulfopropanoic | 40, 124 |
| abstract_inverted_index.neurodegenerative | 12 |
| abstract_inverted_index.neurodegeneration, | 136 |
| abstract_inverted_index.pathophysiological | 97 |
| abstract_inverted_index.approach—including | 65 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5089102372, https://openalex.org/A5003693498, https://openalex.org/A5031390336, https://openalex.org/A5007471774, https://openalex.org/A5025398783 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 26 |
| corresponding_institution_ids | https://openalex.org/I21449261, https://openalex.org/I4210102302, https://openalex.org/I4210115043, https://openalex.org/I4210136987, https://openalex.org/I44504214 |
| citation_normalized_percentile.value | 0.36597154 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |