Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity? Article Swipe
Samuel da Silva Aguiar
,
Thiago dos Santos Rosa
,
Rodrigo Vanerson Passos Neves
,
Patrício L. A. Leite
,
Larissa Alves Maciel
,
Sara Duarte Gutierrez
,
Érica Carine Campos Caldas Rosa
,
Rosângela Vieira de Andrade
,
Hans Degens
,
Marko T. Korhonen
,
John E. Lewis
,
Herbert Gustavo Simões
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1055/a-1510-9259
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1055/a-1510-9259
Lower SIRT1 and insulin resistance are associated with accelerated telomere shortening. This study investigated whether the lifestyle of master athletes can attenuate these age-related changes and thereby slow aging. We compared insulin, SIRT1, and telomere length in highly trained male master athletes (n=52; aged 49.9±7.2 yrs) and age-matched non-athletes (n=19; aged 47.3±8.9 yrs). This is a cross-sectional study, in which all data were collected in one visit. Overnight fasted SIRT1 and insulin levels in whole blood were assessed using commercial kits. Relative telomere length was determined in leukocytes through qPCR analyses. Master athletes had higher SIRT1, lower insulin, and longer telomere length than age-matched non-athletes (p<0.05 for all). Insulin was inversely associated with SIRT1 (r=−0.38; p=0.001). Telomere length correlated positively with SIRT1 (r=0.65; p=0.001), whereas telomere length and insulin were not correlated (r=0.03; p=0.87). In conclusion, master athletes have higher SIRT1, lower insulin, and longer telomeres than age-matched non-athletes. Furthermore, SIRT1 was negatively associated with insulin and positively associated with telomere length. These findings suggest that in this sample of middle-aged participants reduced insulin, increased SIRT1 activity, and attenuation of biological aging are connected.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1055/a-1510-9259
- http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1510-9259.pdf
- OA Status
- bronze
- Cited By
- 8
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3177576378
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3177576378Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1055/a-1510-9259Digital Object Identifier
- Title
-
Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity?Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-07-13Full publication date if available
- Authors
-
Samuel da Silva Aguiar, Thiago dos Santos Rosa, Rodrigo Vanerson Passos Neves, Patrício L. A. Leite, Larissa Alves Maciel, Sara Duarte Gutierrez, Érica Carine Campos Caldas Rosa, Rosângela Vieira de Andrade, Hans Degens, Marko T. Korhonen, John E. Lewis, Herbert Gustavo SimõesList of authors in order
- Landing page
-
https://doi.org/10.1055/a-1510-9259Publisher landing page
- PDF URL
-
https://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1510-9259.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1510-9259.pdfDirect OA link when available
- Concepts
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Telomere, Insulin, Internal medicine, Endocrinology, Medicine, Athletes, Insulin resistance, Longevity, Biology, Gerontology, Genetics, Physical therapy, DNATop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 3, 2023: 3, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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34Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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