Temozolomide-Induced RNA Interactome Uncovers Novel LncRNA Regulatory Loops in Glioblastoma Article Swipe
Sabrina Fritah
,
Arnaud Muller
,
Wei Jiang
,
Ramkrishna Mitra
,
Mohamad Sarmini
,
Monika Dieterle
,
Anna Golebiewska
,
Tao Ye
,
Eric Van Dyck
,
Christel Herold‐Mende
,
Zhongming Zhao
,
Francisco Azuaje
,
Simone P. Niclou
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/cancers12092583
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/cancers12092583
Resistance to chemotherapy by temozolomide (TMZ) is a major cause of glioblastoma (GBM) recurrence. So far, attempts to characterize factors that contribute to TMZ sensitivity have largely focused on protein-coding genes, and failed to provide effective therapeutic targets. Long noncoding RNAs (lncRNAs) are essential regulators of epigenetic-driven cell diversification, yet, their contribution to the transcriptional response to drugs is less understood. Here, we performed RNA-seq and small RNA-seq to provide a comprehensive map of transcriptome regulation upon TMZ in patient-derived GBM stem-like cells displaying different drug sensitivity. In a search for regulatory mechanisms, we integrated thousands of molecular associations stored in public databases to generate a background “RNA interactome”. Our systems-level analysis uncovered a coordinated program of TMZ response reflected by regulatory circuits that involve transcription factors, mRNAs, miRNAs, and lncRNAs. We discovered 22 lncRNAs involved in regulatory loops and/or with functional relevance in drug response and prognostic value in gliomas. Thus, the investigation of TMZ-induced gene networks highlights novel RNA-based predictors of chemosensitivity in GBM. The computational modeling used to identify regulatory circuits underlying drug response and prioritizing gene candidates for functional validation is applicable to other datasets.
Related Topics
Concepts
Interactome
Transcriptome
Biology
Computational biology
Temozolomide
microRNA
Epigenetics
Non-coding RNA
Gene regulatory network
Gene
Long non-coding RNA
RNA
Regulation of gene expression
Gene expression
Bioinformatics
Cancer research
Glioblastoma
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers12092583
- https://www.mdpi.com/2072-6694/12/9/2583/pdf
- OA Status
- gold
- Cited By
- 8
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3083829023
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3083829023Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cancers12092583Digital Object Identifier
- Title
-
Temozolomide-Induced RNA Interactome Uncovers Novel LncRNA Regulatory Loops in GlioblastomaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-09-10Full publication date if available
- Authors
-
Sabrina Fritah, Arnaud Muller, Wei Jiang, Ramkrishna Mitra, Mohamad Sarmini, Monika Dieterle, Anna Golebiewska, Tao Ye, Eric Van Dyck, Christel Herold‐Mende, Zhongming Zhao, Francisco Azuaje, Simone P. NiclouList of authors in order
- Landing page
-
https://doi.org/10.3390/cancers12092583Publisher landing page
- PDF URL
-
https://www.mdpi.com/2072-6694/12/9/2583/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2072-6694/12/9/2583/pdfDirect OA link when available
- Concepts
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Interactome, Transcriptome, Biology, Computational biology, Temozolomide, microRNA, Epigenetics, Non-coding RNA, Gene regulatory network, Gene, Long non-coding RNA, RNA, Regulation of gene expression, Gene expression, Bioinformatics, Cancer research, Glioblastoma, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1, 2023: 1, 2022: 2, 2021: 3Per-year citation counts (last 5 years)
- References (count)
-
69Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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