Temperature compensation through kinetic regulation in biochemical oscillators Article Swipe
Haochen Fu
,
Chenyi Fei
,
Qi Ouyang
,
Yuhai Tu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2401567121
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2401567121
Nearly all circadian clocks maintain a period that is insensitive to temperature changes, a phenomenon known as temperature compensation (TC). Yet, it is unclear whether there is any common feature among different systems that exhibit TC. From a general timescale invariance, we show that TC relies on the existence of certain period-lengthening reactions wherein the period of the system increases strongly with the rates in these reactions. By studying several generic oscillator models, we show that this counterintuitive dependence is nonetheless a common feature of oscillators in the nonlinear (far-from-onset) regime where the oscillation can be separated into fast and slow phases. The increase of the period with the period-lengthening reaction rates occurs when the amplitude of the slow phase in the oscillation increases with these rates while the progression speed in the slow phase is controlled by other rates of the system. The positive dependence of the period on the period-lengthening rates balances its inverse dependence on other kinetic rates in the system, which gives rise to robust TC in a wide range of parameters. We demonstrate the existence of such period-lengthening reactions and their relevance for TC in all four model systems we considered. Theoretical results for a model of the Kai system are supported by experimental data. A study of the energy dissipation also shows that better TC performance requires higher energy consumption. Our study unveils a general mechanism by which a biochemical oscillator achieves TC by operating in parameter regimes far from the onset where period-lengthening reactions exist.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.2401567121
- OA Status
- green
- Cited By
- 3
- References
- 63
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://doi.org/10.1073/pnas.2401567121Digital Object Identifier
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Temperature compensation through kinetic regulation in biochemical oscillatorsWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-05-15Full publication date if available
- Authors
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Haochen Fu, Chenyi Fei, Qi Ouyang, Yuhai TuList of authors in order
- Landing page
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https://doi.org/10.1073/pnas.2401567121Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/11127053Direct OA link when available
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Dissipation, Oscillation (cell signaling), Kinetic energy, Amplitude, Physics, Range (aeronautics), Period (music), Chemistry, Thermodynamics, Statistical physics, Materials science, Quantum mechanics, Acoustics, Biochemistry, Composite materialTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2025: 3Per-year citation counts (last 5 years)
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| publication_date | 2024-05-15 |
| publication_year | 2024 |
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