Temperature-Responsive Liposome-Linked Immunosorbent Assay for the Rapid Detection of SARS-CoV-2 Using Immunoliposomes Article Swipe
Runkai Hu
,
Morihiro Hotta
,
Taro Maruyama
,
Mizuki Fujisawa
,
Keitaro Sou
,
Shinji Takeoka
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1021/acsomega.2c03597
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1021/acsomega.2c03597
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the etiological agent of coronavirus disease 2019 (COVID-19), has infected more than 340 million people since the outbreak of the pandemic in 2019, resulting in approximately 55 million deaths. The rapid and effective diagnosis of COVID-19 patients is vital to prevent the spread of the disease. In a previous study, we reported a novel temperature-responsive liposome-linked immunosorbent assay (TLip-LISA) using biotinylated-TLip that exhibited high detection sensitivity for the prostate-specific antigen. Herein, we used immunoglobulin-TLip (IgG-TLip), in which the antibodies were directly conjugated to the liposomal surface to simplify pretreatment procedures and reduce the detection time for SARS-CoV-2. The results indicated that TLip-LISA could detect the recombinant nucleocapsid protein and the nucleocapsid protein in inactivated virus with 20 min incubation time in total, and the limit of detection was calculated to be 2.2 and 1.0 pg/mL, respectively. Therefore, TLip-LISA has high potential to be used in clinic for rapid diagnosis and disease control.
Related Topics
Concepts
Biotinylation
Virology
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Coronavirus
Antibody
Antigen
Liposome
Detection limit
Medicine
Outbreak
Recombinant DNA
Virus
Pandemic
Molecular biology
Disease
Biology
Immunology
Chemistry
Chromatography
Infectious disease (medical specialty)
Gene
Internal medicine
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acsomega.2c03597
- https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c03597
- OA Status
- gold
- Cited By
- 4
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4286489334
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4286489334Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1021/acsomega.2c03597Digital Object Identifier
- Title
-
Temperature-Responsive Liposome-Linked Immunosorbent Assay for the Rapid Detection of SARS-CoV-2 Using ImmunoliposomesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-07-21Full publication date if available
- Authors
-
Runkai Hu, Morihiro Hotta, Taro Maruyama, Mizuki Fujisawa, Keitaro Sou, Shinji TakeokaList of authors in order
- Landing page
-
https://doi.org/10.1021/acsomega.2c03597Publisher landing page
- PDF URL
-
https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c03597Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c03597Direct OA link when available
- Concepts
-
Biotinylation, Virology, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Coronavirus, Antibody, Antigen, Liposome, Detection limit, Medicine, Outbreak, Recombinant DNA, Virus, Pandemic, Molecular biology, Disease, Biology, Immunology, Chemistry, Chromatography, Infectious disease (medical specialty), Gene, Internal medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2023: 1, 2022: 2Per-year citation counts (last 5 years)
- References (count)
-
36Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4286489334 |
|---|---|
| doi | https://doi.org/10.1021/acsomega.2c03597 |
| ids.doi | https://doi.org/10.1021/acsomega.2c03597 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/35915635 |
| ids.openalex | https://openalex.org/W4286489334 |
| fwci | 0.50072718 |
| type | article |
| title | Temperature-Responsive Liposome-Linked Immunosorbent Assay for the Rapid Detection of SARS-CoV-2 Using Immunoliposomes |
| biblio.issue | 30 |
| biblio.volume | 7 |
| biblio.last_page | 26944 |
| biblio.first_page | 26936 |
| grants[0].funder | https://openalex.org/F4320311405 |
| grants[0].award_id | JP21lm0203004 |
| grants[0].funder_display_name | Japan Agency for Medical Research and Development |
| topics[0].id | https://openalex.org/T11754 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2725 |
| topics[0].subfield.display_name | Infectious Diseases |
| topics[0].display_name | SARS-CoV-2 detection and testing |
| topics[1].id | https://openalex.org/T11393 |
| topics[1].field.id | https://openalex.org/fields/22 |
| topics[1].field.display_name | Engineering |
| topics[1].score | 0.9995999932289124 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2204 |
| topics[1].subfield.display_name | Biomedical Engineering |
| topics[1].display_name | Biosensors and Analytical Detection |
| topics[2].id | https://openalex.org/T10118 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9993000030517578 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2725 |
| topics[2].subfield.display_name | Infectious Diseases |
| topics[2].display_name | SARS-CoV-2 and COVID-19 Research |
| funders[0].id | https://openalex.org/F4320311405 |
| funders[0].ror | https://ror.org/004rtk039 |
| funders[0].display_name | Japan Agency for Medical Research and Development |
| is_xpac | False |
| apc_list.value | 1685 |
| apc_list.currency | USD |
| apc_list.value_usd | 1685 |
| apc_paid.value | 1685 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 1685 |
| concepts[0].id | https://openalex.org/C204628709 |
| concepts[0].level | 2 |
| concepts[0].score | 0.8167717456817627 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q864854 |
| concepts[0].display_name | Biotinylation |
| concepts[1].id | https://openalex.org/C159047783 |
| concepts[1].level | 1 |
| concepts[1].score | 0.7232588529586792 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q7215 |
| concepts[1].display_name | Virology |
| concepts[2].id | https://openalex.org/C3008058167 |
| concepts[2].level | 4 |
| concepts[2].score | 0.6293101906776428 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q84263196 |
| concepts[2].display_name | Coronavirus disease 2019 (COVID-19) |
| concepts[3].id | https://openalex.org/C3007834351 |
| concepts[3].level | 5 |
| concepts[3].score | 0.609411358833313 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q82069695 |
| concepts[3].display_name | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| concepts[4].id | https://openalex.org/C2777648638 |
| concepts[4].level | 5 |
| concepts[4].score | 0.592115044593811 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q57751738 |
| concepts[4].display_name | Coronavirus |
| concepts[5].id | https://openalex.org/C159654299 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5660208463668823 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q79460 |
| concepts[5].display_name | Antibody |
| concepts[6].id | https://openalex.org/C147483822 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5213181376457214 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q103537 |
| concepts[6].display_name | Antigen |
| concepts[7].id | https://openalex.org/C185154212 |
| concepts[7].level | 2 |
| concepts[7].score | 0.5171391367912292 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q410454 |
| concepts[7].display_name | Liposome |
| concepts[8].id | https://openalex.org/C119128265 |
| concepts[8].level | 2 |
| concepts[8].score | 0.49673277139663696 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q900165 |
| concepts[8].display_name | Detection limit |
| concepts[9].id | https://openalex.org/C71924100 |
| concepts[9].level | 0 |
| concepts[9].score | 0.4738764464855194 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[9].display_name | Medicine |
| concepts[10].id | https://openalex.org/C116675565 |
| concepts[10].level | 2 |
| concepts[10].score | 0.473806768655777 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q3241045 |
| concepts[10].display_name | Outbreak |
| concepts[11].id | https://openalex.org/C40767141 |
| concepts[11].level | 3 |
| concepts[11].score | 0.46114760637283325 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q285697 |
| concepts[11].display_name | Recombinant DNA |
| concepts[12].id | https://openalex.org/C2522874641 |
| concepts[12].level | 2 |
| concepts[12].score | 0.44733062386512756 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q808 |
| concepts[12].display_name | Virus |
| concepts[13].id | https://openalex.org/C89623803 |
| concepts[13].level | 5 |
| concepts[13].score | 0.4417553246021271 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q12184 |
| concepts[13].display_name | Pandemic |
| concepts[14].id | https://openalex.org/C153911025 |
| concepts[14].level | 1 |
| concepts[14].score | 0.3400559425354004 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7202 |
| concepts[14].display_name | Molecular biology |
| concepts[15].id | https://openalex.org/C2779134260 |
| concepts[15].level | 2 |
| concepts[15].score | 0.3289351761341095 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[15].display_name | Disease |
| concepts[16].id | https://openalex.org/C86803240 |
| concepts[16].level | 0 |
| concepts[16].score | 0.28719407320022583 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[16].display_name | Biology |
| concepts[17].id | https://openalex.org/C203014093 |
| concepts[17].level | 1 |
| concepts[17].score | 0.2671474516391754 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[17].display_name | Immunology |
| concepts[18].id | https://openalex.org/C185592680 |
| concepts[18].level | 0 |
| concepts[18].score | 0.263991117477417 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[18].display_name | Chemistry |
| concepts[19].id | https://openalex.org/C43617362 |
| concepts[19].level | 1 |
| concepts[19].score | 0.2104707658290863 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q170050 |
| concepts[19].display_name | Chromatography |
| concepts[20].id | https://openalex.org/C524204448 |
| concepts[20].level | 3 |
| concepts[20].score | 0.18628305196762085 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q788926 |
| concepts[20].display_name | Infectious disease (medical specialty) |
| concepts[21].id | https://openalex.org/C104317684 |
| concepts[21].level | 2 |
| concepts[21].score | 0.10988706350326538 |
| concepts[21].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[21].display_name | Gene |
| concepts[22].id | https://openalex.org/C126322002 |
| concepts[22].level | 1 |
| concepts[22].score | 0.10119098424911499 |
| concepts[22].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[22].display_name | Internal medicine |
| concepts[23].id | https://openalex.org/C55493867 |
| concepts[23].level | 1 |
| concepts[23].score | 0.0778038501739502 |
| concepts[23].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[23].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/biotinylation |
| keywords[0].score | 0.8167717456817627 |
| keywords[0].display_name | Biotinylation |
| keywords[1].id | https://openalex.org/keywords/virology |
| keywords[1].score | 0.7232588529586792 |
| keywords[1].display_name | Virology |
| keywords[2].id | https://openalex.org/keywords/coronavirus-disease-2019 |
| keywords[2].score | 0.6293101906776428 |
| keywords[2].display_name | Coronavirus disease 2019 (COVID-19) |
| keywords[3].id | https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2 |
| keywords[3].score | 0.609411358833313 |
| keywords[3].display_name | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| keywords[4].id | https://openalex.org/keywords/coronavirus |
| keywords[4].score | 0.592115044593811 |
| keywords[4].display_name | Coronavirus |
| keywords[5].id | https://openalex.org/keywords/antibody |
| keywords[5].score | 0.5660208463668823 |
| keywords[5].display_name | Antibody |
| keywords[6].id | https://openalex.org/keywords/antigen |
| keywords[6].score | 0.5213181376457214 |
| keywords[6].display_name | Antigen |
| keywords[7].id | https://openalex.org/keywords/liposome |
| keywords[7].score | 0.5171391367912292 |
| keywords[7].display_name | Liposome |
| keywords[8].id | https://openalex.org/keywords/detection-limit |
| keywords[8].score | 0.49673277139663696 |
| keywords[8].display_name | Detection limit |
| keywords[9].id | https://openalex.org/keywords/medicine |
| keywords[9].score | 0.4738764464855194 |
| keywords[9].display_name | Medicine |
| keywords[10].id | https://openalex.org/keywords/outbreak |
| keywords[10].score | 0.473806768655777 |
| keywords[10].display_name | Outbreak |
| keywords[11].id | https://openalex.org/keywords/recombinant-dna |
| keywords[11].score | 0.46114760637283325 |
| keywords[11].display_name | Recombinant DNA |
| keywords[12].id | https://openalex.org/keywords/virus |
| keywords[12].score | 0.44733062386512756 |
| keywords[12].display_name | Virus |
| keywords[13].id | https://openalex.org/keywords/pandemic |
| keywords[13].score | 0.4417553246021271 |
| keywords[13].display_name | Pandemic |
| keywords[14].id | https://openalex.org/keywords/molecular-biology |
| keywords[14].score | 0.3400559425354004 |
| keywords[14].display_name | Molecular biology |
| keywords[15].id | https://openalex.org/keywords/disease |
| keywords[15].score | 0.3289351761341095 |
| keywords[15].display_name | Disease |
| keywords[16].id | https://openalex.org/keywords/biology |
| keywords[16].score | 0.28719407320022583 |
| keywords[16].display_name | Biology |
| keywords[17].id | https://openalex.org/keywords/immunology |
| keywords[17].score | 0.2671474516391754 |
| keywords[17].display_name | Immunology |
| keywords[18].id | https://openalex.org/keywords/chemistry |
| keywords[18].score | 0.263991117477417 |
| keywords[18].display_name | Chemistry |
| keywords[19].id | https://openalex.org/keywords/chromatography |
| keywords[19].score | 0.2104707658290863 |
| keywords[19].display_name | Chromatography |
| keywords[20].id | https://openalex.org/keywords/infectious-disease |
| keywords[20].score | 0.18628305196762085 |
| keywords[20].display_name | Infectious disease (medical specialty) |
| keywords[21].id | https://openalex.org/keywords/gene |
| keywords[21].score | 0.10988706350326538 |
| keywords[21].display_name | Gene |
| keywords[22].id | https://openalex.org/keywords/internal-medicine |
| keywords[22].score | 0.10119098424911499 |
| keywords[22].display_name | Internal medicine |
| keywords[23].id | https://openalex.org/keywords/biochemistry |
| keywords[23].score | 0.0778038501739502 |
| keywords[23].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.1021/acsomega.2c03597 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210239500 |
| locations[0].source.issn | 2470-1343 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2470-1343 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | ACS Omega |
| locations[0].source.host_organization | https://openalex.org/P4310320006 |
| locations[0].source.host_organization_name | American Chemical Society |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320006 |
| locations[0].license | |
| locations[0].pdf_url | https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c03597 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | ACS Omega |
| locations[0].landing_page_url | https://doi.org/10.1021/acsomega.2c03597 |
| locations[1].id | pmid:35915635 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | ACS omega |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/35915635 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:9328125 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | ACS Omega |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9328125 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5086171490 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Runkai Hu |
| authorships[0].countries | JP |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I150744194 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162-8480, Japan |
| authorships[0].institutions[0].id | https://openalex.org/I150744194 |
| authorships[0].institutions[0].ror | https://ror.org/00ntfnx83 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I150744194 |
| authorships[0].institutions[0].country_code | JP |
| authorships[0].institutions[0].display_name | Waseda University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Runkai Hu |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162-8480, Japan |
| authorships[1].author.id | https://openalex.org/A5076143028 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-2354-0988 |
| authorships[1].author.display_name | Morihiro Hotta |
| authorships[1].countries | JP |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I150744194 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162-8480, Japan |
| authorships[1].institutions[0].id | https://openalex.org/I150744194 |
| authorships[1].institutions[0].ror | https://ror.org/00ntfnx83 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I150744194 |
| authorships[1].institutions[0].country_code | JP |
| authorships[1].institutions[0].display_name | Waseda University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Morihiro Hotta |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162-8480, Japan |
| authorships[2].author.id | https://openalex.org/A5109132579 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Taro Maruyama |
| authorships[2].countries | JP |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I150744194 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162-8480, Japan |
| authorships[2].institutions[0].id | https://openalex.org/I150744194 |
| authorships[2].institutions[0].ror | https://ror.org/00ntfnx83 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I150744194 |
| authorships[2].institutions[0].country_code | JP |
| authorships[2].institutions[0].display_name | Waseda University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Taro Maruyama |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162-8480, Japan |
| authorships[3].author.id | https://openalex.org/A5068508916 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-9491-0886 |
| authorships[3].author.display_name | Mizuki Fujisawa |
| authorships[3].countries | JP |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I150744194 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162-8480, Japan |
| authorships[3].institutions[0].id | https://openalex.org/I150744194 |
| authorships[3].institutions[0].ror | https://ror.org/00ntfnx83 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I150744194 |
| authorships[3].institutions[0].country_code | JP |
| authorships[3].institutions[0].display_name | Waseda University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Mizuki Fujisawa |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162-8480, Japan |
| authorships[4].author.id | https://openalex.org/A5090954248 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-5449-9084 |
| authorships[4].author.display_name | Keitaro Sou |
| authorships[4].countries | JP |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I150744194 |
| authorships[4].affiliations[0].raw_affiliation_string | Waseda Research Institute for Science and Engineering, Waseda University, Tokyo 169-8555, Japan |
| authorships[4].institutions[0].id | https://openalex.org/I150744194 |
| authorships[4].institutions[0].ror | https://ror.org/00ntfnx83 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I150744194 |
| authorships[4].institutions[0].country_code | JP |
| authorships[4].institutions[0].display_name | Waseda University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Keitaro Sou |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | Waseda Research Institute for Science and Engineering, Waseda University, Tokyo 169-8555, Japan |
| authorships[5].author.id | https://openalex.org/A5037131620 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-6230-1517 |
| authorships[5].author.display_name | Shinji Takeoka |
| authorships[5].countries | JP |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I150744194 |
| authorships[5].affiliations[0].raw_affiliation_string | Institute for Advanced Research of Biosystem Dynamics, Waseda Research Institute for Science and Engineering, Waseda University, Tokyo 169-8555, Japan |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I150744194 |
| authorships[5].affiliations[1].raw_affiliation_string | Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162-8480, Japan |
| authorships[5].institutions[0].id | https://openalex.org/I150744194 |
| authorships[5].institutions[0].ror | https://ror.org/00ntfnx83 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I150744194 |
| authorships[5].institutions[0].country_code | JP |
| authorships[5].institutions[0].display_name | Waseda University |
| authorships[5].author_position | last |
| authorships[5].raw_author_name | Shinji Takeoka |
| authorships[5].is_corresponding | True |
| authorships[5].raw_affiliation_strings | Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162-8480, Japan, Institute for Advanced Research of Biosystem Dynamics, Waseda Research Institute for Science and Engineering, Waseda University, Tokyo 169-8555, Japan |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c03597 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Temperature-Responsive Liposome-Linked Immunosorbent Assay for the Rapid Detection of SARS-CoV-2 Using Immunoliposomes |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11754 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2725 |
| primary_topic.subfield.display_name | Infectious Diseases |
| primary_topic.display_name | SARS-CoV-2 detection and testing |
| related_works | https://openalex.org/W2167565828, https://openalex.org/W31233013, https://openalex.org/W4230407305, https://openalex.org/W2477997617, https://openalex.org/W1580366551, https://openalex.org/W2765968230, https://openalex.org/W2439544196, https://openalex.org/W2077013469, https://openalex.org/W1986898545, https://openalex.org/W1984466188 |
| cited_by_count | 4 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 1 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 2 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1021/acsomega.2c03597 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210239500 |
| best_oa_location.source.issn | 2470-1343 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2470-1343 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | ACS Omega |
| best_oa_location.source.host_organization | https://openalex.org/P4310320006 |
| best_oa_location.source.host_organization_name | American Chemical Society |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320006 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c03597 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | ACS Omega |
| best_oa_location.landing_page_url | https://doi.org/10.1021/acsomega.2c03597 |
| primary_location.id | doi:10.1021/acsomega.2c03597 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210239500 |
| primary_location.source.issn | 2470-1343 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2470-1343 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | ACS Omega |
| primary_location.source.host_organization | https://openalex.org/P4310320006 |
| primary_location.source.host_organization_name | American Chemical Society |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320006 |
| primary_location.license | |
| primary_location.pdf_url | https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c03597 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | ACS Omega |
| primary_location.landing_page_url | https://doi.org/10.1021/acsomega.2c03597 |
| publication_date | 2022-07-21 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W3001897055, https://openalex.org/W2169198329, https://openalex.org/W2233931087, https://openalex.org/W3027002382, https://openalex.org/W1544561280, https://openalex.org/W1965435260, https://openalex.org/W3040801404, https://openalex.org/W3199510249, https://openalex.org/W3117730334, https://openalex.org/W3185390558, https://openalex.org/W3160145931, https://openalex.org/W2989769422, https://openalex.org/W3024006735, https://openalex.org/W3111602384, https://openalex.org/W3156271472, https://openalex.org/W3211297703, https://openalex.org/W3146201568, https://openalex.org/W3181479895, https://openalex.org/W3009906937, https://openalex.org/W3048917590, https://openalex.org/W3032292222, https://openalex.org/W3094220144, https://openalex.org/W2153198148, https://openalex.org/W3010955108, https://openalex.org/W2991119406, https://openalex.org/W3199672667, https://openalex.org/W3193846555, https://openalex.org/W3135710118, https://openalex.org/W3109555858, https://openalex.org/W3110175658, https://openalex.org/W3035051352, https://openalex.org/W4212857232, https://openalex.org/W3089666600, https://openalex.org/W3081401487, https://openalex.org/W4225875164, https://openalex.org/W4206667760 |
| referenced_works_count | 36 |
| abstract_inverted_index.2 | 5 |
| abstract_inverted_index.a | 56, 61 |
| abstract_inverted_index.20 | 125 |
| abstract_inverted_index.55 | 35 |
| abstract_inverted_index.In | 55 |
| abstract_inverted_index.be | 139, 151 |
| abstract_inverted_index.in | 30, 33, 84, 121, 129, 153 |
| abstract_inverted_index.is | 8, 46 |
| abstract_inverted_index.of | 12, 27, 43, 52, 134 |
| abstract_inverted_index.to | 48, 91, 95, 138, 150 |
| abstract_inverted_index.we | 59, 80 |
| abstract_inverted_index.1.0 | 142 |
| abstract_inverted_index.2.2 | 140 |
| abstract_inverted_index.340 | 21 |
| abstract_inverted_index.The | 38, 106 |
| abstract_inverted_index.and | 40, 99, 117, 131, 141, 158 |
| abstract_inverted_index.for | 75, 104, 155 |
| abstract_inverted_index.has | 17, 147 |
| abstract_inverted_index.min | 126 |
| abstract_inverted_index.the | 9, 25, 28, 50, 53, 76, 86, 92, 101, 113, 118, 132 |
| abstract_inverted_index.was | 136 |
| abstract_inverted_index.2019 | 15 |
| abstract_inverted_index.high | 72, 148 |
| abstract_inverted_index.more | 19 |
| abstract_inverted_index.than | 20 |
| abstract_inverted_index.that | 70, 109 |
| abstract_inverted_index.time | 103, 128 |
| abstract_inverted_index.used | 81, 152 |
| abstract_inverted_index.were | 88 |
| abstract_inverted_index.with | 124 |
| abstract_inverted_index.2019, | 31 |
| abstract_inverted_index.acute | 1 |
| abstract_inverted_index.agent | 11 |
| abstract_inverted_index.assay | 66 |
| abstract_inverted_index.could | 111 |
| abstract_inverted_index.limit | 133 |
| abstract_inverted_index.novel | 62 |
| abstract_inverted_index.rapid | 39, 156 |
| abstract_inverted_index.since | 24 |
| abstract_inverted_index.using | 68 |
| abstract_inverted_index.virus | 123 |
| abstract_inverted_index.vital | 47 |
| abstract_inverted_index.which | 7, 85 |
| abstract_inverted_index.Severe | 0 |
| abstract_inverted_index.clinic | 154 |
| abstract_inverted_index.detect | 112 |
| abstract_inverted_index.people | 23 |
| abstract_inverted_index.pg/mL, | 143 |
| abstract_inverted_index.reduce | 100 |
| abstract_inverted_index.spread | 51 |
| abstract_inverted_index.study, | 58 |
| abstract_inverted_index.total, | 130 |
| abstract_inverted_index.Herein, | 79 |
| abstract_inverted_index.deaths. | 37 |
| abstract_inverted_index.disease | 14, 159 |
| abstract_inverted_index.million | 22, 36 |
| abstract_inverted_index.prevent | 49 |
| abstract_inverted_index.protein | 116, 120 |
| abstract_inverted_index.results | 107 |
| abstract_inverted_index.surface | 94 |
| abstract_inverted_index.COVID-19 | 44 |
| abstract_inverted_index.antigen. | 78 |
| abstract_inverted_index.control. | 160 |
| abstract_inverted_index.directly | 89 |
| abstract_inverted_index.disease. | 54 |
| abstract_inverted_index.infected | 18 |
| abstract_inverted_index.outbreak | 26 |
| abstract_inverted_index.pandemic | 29 |
| abstract_inverted_index.patients | 45 |
| abstract_inverted_index.previous | 57 |
| abstract_inverted_index.reported | 60 |
| abstract_inverted_index.simplify | 96 |
| abstract_inverted_index.syndrome | 3 |
| abstract_inverted_index.TLip-LISA | 110, 146 |
| abstract_inverted_index.detection | 73, 102, 135 |
| abstract_inverted_index.diagnosis | 42, 157 |
| abstract_inverted_index.effective | 41 |
| abstract_inverted_index.exhibited | 71 |
| abstract_inverted_index.indicated | 108 |
| abstract_inverted_index.liposomal | 93 |
| abstract_inverted_index.potential | 149 |
| abstract_inverted_index.resulting | 32 |
| abstract_inverted_index.Therefore, | 145 |
| abstract_inverted_index.antibodies | 87 |
| abstract_inverted_index.calculated | 137 |
| abstract_inverted_index.conjugated | 90 |
| abstract_inverted_index.incubation | 127 |
| abstract_inverted_index.procedures | 98 |
| abstract_inverted_index.(COVID-19), | 16 |
| abstract_inverted_index.(IgG-TLip), | 83 |
| abstract_inverted_index.(TLip-LISA) | 67 |
| abstract_inverted_index.SARS-CoV-2. | 105 |
| abstract_inverted_index.coronavirus | 4, 13 |
| abstract_inverted_index.etiological | 10 |
| abstract_inverted_index.inactivated | 122 |
| abstract_inverted_index.recombinant | 114 |
| abstract_inverted_index.respiratory | 2 |
| abstract_inverted_index.sensitivity | 74 |
| abstract_inverted_index.nucleocapsid | 115, 119 |
| abstract_inverted_index.pretreatment | 97 |
| abstract_inverted_index.(SARS-CoV-2), | 6 |
| abstract_inverted_index.approximately | 34 |
| abstract_inverted_index.immunosorbent | 65 |
| abstract_inverted_index.respectively. | 144 |
| abstract_inverted_index.liposome-linked | 64 |
| abstract_inverted_index.biotinylated-TLip | 69 |
| abstract_inverted_index.prostate-specific | 77 |
| abstract_inverted_index.immunoglobulin-TLip | 82 |
| abstract_inverted_index.temperature-responsive | 63 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5037131620, https://openalex.org/A5090954248 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I150744194 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8700000047683716 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.61521319 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |