Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis Article Swipe
Tanzila Mukhtar
,
Jérémie Breda
,
Manal A. Adam
,
Marcelo Boareto
,
Pascal Grobecker
,
Zahra Karimaddini
,
Alice Grison
,
Katja Eschbach
,
Chandrasekhar Ramakrishnan
,
Swen Vermeul
,
Michał Okoniewski
,
Mikhail Pachkov
,
Corey C. Harwell
,
Suzana Atanasoski
,
Christian Beisel
,
Dagmar Iber
,
Erik van Nimwegen
,
Verdon Taylor
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.15252/embj.2022111132
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.15252/embj.2022111132
The cerebral cortex contains billions of neurons, and their disorganization or misspecification leads to neurodevelopmental disorders. Understanding how the plethora of projection neuron subtypes are generated by cortical neural stem cells (NSCs) is a major challenge. Here, we focused on elucidating the transcriptional landscape of murine embryonic NSCs, basal progenitors (BPs), and newborn neurons (NBNs) throughout cortical development. We uncover dynamic shifts in transcriptional space over time and heterogeneity within each progenitor population. We identified signature hallmarks of NSC, BP, and NBN clusters and predict active transcriptional nodes and networks that contribute to neural fate specification. We find that the expression of receptors, ligands, and downstream pathway components is highly dynamic over time and throughout the lineage implying differential responsiveness to signals. Thus, we provide an expansive compendium of gene expression during cortical development that will be an invaluable resource for studying neural developmental processes and neurodevelopmental disorders.
Related Topics
Concepts
Corticogenesis
Biology
Neuroscience
Neural stem cell
Progenitor
Lineage (genetic)
Progenitor cell
Neurogenesis
Genetics
Gene
Stem cell
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.15252/embj.2022111132
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2022111132
- OA Status
- hybrid
- Cited By
- 14
- References
- 95
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4308554780
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4308554780Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.15252/embj.2022111132Digital Object Identifier
- Title
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Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-11-08Full publication date if available
- Authors
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Tanzila Mukhtar, Jérémie Breda, Manal A. Adam, Marcelo Boareto, Pascal Grobecker, Zahra Karimaddini, Alice Grison, Katja Eschbach, Chandrasekhar Ramakrishnan, Swen Vermeul, Michał Okoniewski, Mikhail Pachkov, Corey C. Harwell, Suzana Atanasoski, Christian Beisel, Dagmar Iber, Erik van Nimwegen, Verdon TaylorList of authors in order
- Landing page
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https://doi.org/10.15252/embj.2022111132Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2022111132Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2022111132Direct OA link when available
- Concepts
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Corticogenesis, Biology, Neuroscience, Neural stem cell, Progenitor, Lineage (genetic), Progenitor cell, Neurogenesis, Genetics, Gene, Stem cellTop concepts (fields/topics) attached by OpenAlex
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14Total citation count in OpenAlex
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2025: 5, 2024: 2, 2023: 7Per-year citation counts (last 5 years)
- References (count)
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95Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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