Temporal Telomere and DNA Damage Responses in the Space Radiation Environment Article Swipe
Jared J. Luxton
,
Miles J. McKenna
,
Lynn Taylor
,
K. George
,
Sara R. Zwart
,
Brian Crucian
,
Viktor R. Drel
,
Francine E. Garrett-Bakelman
,
Matthew MacKay
,
Daniel Butler
,
Jonathan Foox
,
Kirill Grigorev
,
Daniela Bezdan
,
Cem Meydan
,
Scott M. Smith
,
Kumar Sharma
,
Christopher E. Mason
,
Susan M. Bailey
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2020.108435
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2020.108435
Telomeres, repetitive terminal features of chromosomes essential for maintaining genome integrity, shorten with cell division, lifestyle factors and stresses, and environmental exposures, and so they provide a robust biomarker of health, aging, and age-related diseases. We assessed telomere length dynamics (changes over time) in three unrelated astronauts before, during, and after 1-year or 6-month missions aboard the International Space Station (ISS). Similar to our results for National Aeronautics and Space Administration's (NASA's) One-Year Mission twin astronaut (Garrett-Bakelman et al., 2019), significantly longer telomeres were observed during spaceflight for two 6-month mission astronauts. Furthermore, telomere length shortened rapidly after return to Earth for all three crewmembers and, overall, telomere length tended to be shorter after spaceflight than before spaceflight. Consistent with chronic exposure to the space radiation environment, signatures of persistent DNA damage responses were also detected, including mitochondrial and oxidative stress, inflammation, and telomeric and chromosomal aberrations, which together provide potential mechanistic insight into spaceflight-specific telomere elongation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.celrep.2020.108435
- http://www.cell.com/article/S2211124720314248/pdf
- OA Status
- gold
- Cited By
- 79
- References
- 100
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3108666086
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3108666086Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.celrep.2020.108435Digital Object Identifier
- Title
-
Temporal Telomere and DNA Damage Responses in the Space Radiation EnvironmentWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-11-25Full publication date if available
- Authors
-
Jared J. Luxton, Miles J. McKenna, Lynn Taylor, K. George, Sara R. Zwart, Brian Crucian, Viktor R. Drel, Francine E. Garrett-Bakelman, Matthew MacKay, Daniel Butler, Jonathan Foox, Kirill Grigorev, Daniela Bezdan, Cem Meydan, Scott M. Smith, Kumar Sharma, Christopher E. Mason, Susan M. BaileyList of authors in order
- Landing page
-
https://doi.org/10.1016/j.celrep.2020.108435Publisher landing page
- PDF URL
-
https://www.cell.com/article/S2211124720314248/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.cell.com/article/S2211124720314248/pdfDirect OA link when available
- Concepts
-
Telomere, DNA damage, DNA, Biology, Genetics, Space radiation, Space (punctuation), Computational biology, Cell biology, Computer science, Physics, Astronomy, Cosmic ray, Operating systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
79Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 14, 2024: 26, 2023: 10, 2022: 10, 2021: 13Per-year citation counts (last 5 years)
- References (count)
-
100Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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