Temporal Tracking of Plasma Cellsin vivoUsing J-chain CreERT2 Reporter System Article Swipe
Timothy C. Borbet
,
Kimberly Zaldaña
,
Anastasia‐Maria Zavitsanou
,
Marcus J. Hines
,
Sofia Bajwa
,
Tate Morrison
,
Thomas Boehringer
,
Victoria M. Hallisey
,
Ken Cadwell
,
Sergei B. Koralov
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.12.02.569736
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.12.02.569736
Plasma cells (PCs) are essential for humoral immunity, as they are responsible for the production of antibodies and contribute to immunological memory. Despite their importance, differentiating between long-lived and short-lived PCs in vivo remains a challenge due to a lack of specific markers to distinguish these populations. Addressing this gap, our study introduces a novel J-chain CreERT2 GFP allele (IgJ CreERT2 ) for precise genetic studies of PCs. This model takes advantage of PC-restricted expression of the J-chain gene, enabling temporal and cell-specific tracking of PCs utilizing a tamoxifen-inducible Cre recombinase. Our in vitro and in vivo validation studies of the inducible Cre allele confirmed the fidelity and utility of this model and demonstrated the model’s ability to trace the long-lived PC population in vivo following immunization. The IgJ CreERT2 model allowed for detailed analysis of surface marker expression on PCs, revealing insights into PC heterogeneity and characteristics. Our findings not only validate the IgJ CreERT2 mouse as a reliable tool for studying PCs but also facilitate the investigation of PC dynamics and longevity, particularly in the context of humoral immunity and vaccine responses. This model represents a significant advancement for the in-depth study of PCs in health and disease, offering a new avenue for the exploration of PC biology and immunological memory.
Related Topics
Concepts
In vivo
Biology
Cre recombinase
Recombinase
Context (archaeology)
Population
Computational biology
Allele
Immunology
Cell biology
Gene
Genetics
Transgene
Genetically modified mouse
Medicine
Recombination
Environmental health
Paleontology
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.12.02.569736
- https://www.biorxiv.org/content/biorxiv/early/2023/12/04/2023.12.02.569736.full.pdf
- OA Status
- green
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389297625
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4389297625Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2023.12.02.569736Digital Object Identifier
- Title
-
Temporal Tracking of Plasma Cellsin vivoUsing J-chain CreERT2 Reporter SystemWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-04Full publication date if available
- Authors
-
Timothy C. Borbet, Kimberly Zaldaña, Anastasia‐Maria Zavitsanou, Marcus J. Hines, Sofia Bajwa, Tate Morrison, Thomas Boehringer, Victoria M. Hallisey, Ken Cadwell, Sergei B. KoralovList of authors in order
- Landing page
-
https://doi.org/10.1101/2023.12.02.569736Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2023/12/04/2023.12.02.569736.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/12/04/2023.12.02.569736.full.pdfDirect OA link when available
- Concepts
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In vivo, Biology, Cre recombinase, Recombinase, Context (archaeology), Population, Computational biology, Allele, Immunology, Cell biology, Gene, Genetics, Transgene, Genetically modified mouse, Medicine, Recombination, Environmental health, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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