Tenofovir alafenamide significantly increased serum lipid levels compared with entecavir therapy in chronic hepatitis B virus patients Article Swipe
Ruimin Lai
,
Shan Lin
,
Miaomiao Wang
,
Na Li
,
Jiahui Zhou
,
Xiaoyu Lin
,
Tianbin Chen
,
Yueyong Zhu
,
Qi Zheng
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.4254/wjh.v15.i8.964
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.4254/wjh.v15.i8.964
Primary sclerosing cholangitis (PSC) is a chronic and progressive immune-mediated cholangiopathy causing biliary tree inflammation and scarring, leading to liver cirrhosis and end-stage liver disease. Diagnosis of PSC is challenging due to its nonspecific symptoms and overlap with other liver diseases. Despite the rising incidence of PSC, there is no proven medical therapy that can alter the natural history of the disease. While liver transplantation (LT) is the most effective approach for managing advanced liver disease caused by PSC, post-transplantation recurrence of PSC remains a challenge. Therefore, ongoing research aims to develop better therapies for PSC, and continued efforts are necessary to improve outcomes for patients with PSC. This article provides an overview of PSC’s pathogenesis, clinical presentation, and management options, including LT trends and future aspects. It also highlights the need for improved therapeutic options and ethical considerations in providing equitable access to LT for patients with PSC. Additionally, the impact of liver transplant on the quality of life and psychological outcomes of patients with PSC is discussed. Ongoing research into PSC’s pathogenesis and post-transplant recurrence is crucial for improved understanding of the disease and more effective treatment options.
Related Topics
Concepts
Medicine
Entecavir
Liver transplantation
Primary sclerosing cholangitis
Cirrhosis
Tenofovir alafenamide
Liver disease
Internal medicine
Pathogenesis
Disease
Natural history
Gastroenterology
Transplantation
Hepatitis B virus
Immunology
Virus
Viral load
Antiretroviral therapy
Lamivudine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4254/wjh.v15.i8.964
- OA Status
- diamond
- Cited By
- 11
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386042321
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386042321Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4254/wjh.v15.i8.964Digital Object Identifier
- Title
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Tenofovir alafenamide significantly increased serum lipid levels compared with entecavir therapy in chronic hepatitis B virus patientsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-08-22Full publication date if available
- Authors
-
Ruimin Lai, Shan Lin, Miaomiao Wang, Na Li, Jiahui Zhou, Xiaoyu Lin, Tianbin Chen, Yueyong Zhu, Qi ZhengList of authors in order
- Landing page
-
https://doi.org/10.4254/wjh.v15.i8.964Publisher landing page
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
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https://doi.org/10.4254/wjh.v15.i8.964Direct OA link when available
- Concepts
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Medicine, Entecavir, Liver transplantation, Primary sclerosing cholangitis, Cirrhosis, Tenofovir alafenamide, Liver disease, Internal medicine, Pathogenesis, Disease, Natural history, Gastroenterology, Transplantation, Hepatitis B virus, Immunology, Virus, Viral load, Antiretroviral therapy, LamivudineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 8Per-year citation counts (last 5 years)
- References (count)
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25Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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