Tensor-based morphometry findings corresponding to the novel serum p-tau 217 biomarkers levels in the Alzheimer’s dementia continuum Article Swipe

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Amirhossein Ghasemiazar , Maryam Sadat Alyasin , Elham Ramezannezhad , Zahra Khodadadi , Mahdieh Dalili , Niloofar Montazer Somehsaraei , Ahmad Reza Bahrami , Arian Bahrami , Shireen Ghorbani , Hosein Haji Parvane , Mohanna Akbarin Mayvani , Mahsa Mayeli , Nafise Niknam ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.21203/rs.3.rs-7318233/v1

Background: Blood, CSF, and imaging biomarkers significantly broaden the global scope of AD diagnosis. The initial changes in all the plasma p-tau biomarkers suggest that they primarily reflect Aβ dysmetabolism. So, they would be highly effective in detecting the early phase of AD. Plasma P-tau217 is a highly accurate predictor of cognitive decline and an effective biomarker for early detection of Alzheimer's disease. It reflects tau pathology associated with AD better than other biomarkers. P-tau217 also better differentiates patients with neurodegenerative disorders from those who do not have neurodegenerative disorders, even better than plasma P-tau218. TBM is an imaging technique that identifies regional structural differences in the brain, reflecting tissue loss in the temporal lobe during aging and dementia, and predicts the conversion of MCI to AD. The current study aims to elucidate the relationship between TBM-derived imaging biomarkers and plasma levels of p-tau217 in a cohort of individuals with MCI and AD. Methods: Data was extracted from the ADNI database, which collected data on people undergoing different test procedures. Based on ADNI criteria, participants were classified into three cognitively normal (CN), MCI, and AD groups. Results: A total of 32 participants with MCI revealed a significant negative correlation between plasma Ptau-217 levels and TBMSYNSCOR. P-tau217 was also identified as a significant predictor of TBMSYNSCOR, explaining 30% of its variability and highlighting its potential as a biomarker for structural brain changes in AD. Conclusion: Our findings demonstrate that higher plasma Ptau-217 levels are associated with lower levels of TBM scores. These two methods are significantly dependent and can complete each other in predicting cognitive function and early AD.

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Type: preprint
Language: en
Landing Page: https://doi.org/10.21203/rs.3.rs-7318233/v1
PDF: https://www.researchsquare.com/article/rs-7318233/latest.pdf
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DOI: https://doi.org/10.21203/rs.3.rs-7318233/v1

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Title: Tensor-based morphometry findings corresponding to the novel serum p-tau 217 biomarkers levels in the Alzheimer’s dementia continuum

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Type: preprint

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Language: en

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Publication year: 2025

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Publication date: 2025-09-09

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Authors: Amirhossein Ghasemiazar, Maryam Sadat Alyasin, Elham Ramezannezhad, Zahra Khodadadi, Mahdieh Dalili, Niloofar Montazer Somehsaraei, Ahmad Reza Bahrami, Arian Bahrami, Shireen Ghorbani, Hosein Haji Parvane, Mohanna Akbarin Mayvani, Mahsa Mayeli, Nafise Niknam

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Landing page: https://doi.org/10.21203/rs.3.rs-7318233/v1

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abstract_inverted_index.function	265
abstract_inverted_index.negative	198
abstract_inverted_index.p-tau217	144
abstract_inverted_index.patients	79
abstract_inverted_index.predicts	121
abstract_inverted_index.reflects	65
abstract_inverted_index.regional	103
abstract_inverted_index.revealed	195
abstract_inverted_index.temporal	114
abstract_inverted_index.P-tau218.	95
abstract_inverted_index.biomarker	57, 227
abstract_inverted_index.cognitive	52, 264
abstract_inverted_index.collected	163
abstract_inverted_index.criteria,	174
abstract_inverted_index.database,	161
abstract_inverted_index.dementia,	119
abstract_inverted_index.dependent	256
abstract_inverted_index.detecting	38
abstract_inverted_index.detection	60
abstract_inverted_index.different	168
abstract_inverted_index.disorders	82
abstract_inverted_index.effective	36, 56
abstract_inverted_index.elucidate	133
abstract_inverted_index.extracted	157
abstract_inverted_index.pathology	67
abstract_inverted_index.potential	224
abstract_inverted_index.predictor	50, 213
abstract_inverted_index.primarily	27
abstract_inverted_index.technique	100
abstract_inverted_index.associated	68, 244
abstract_inverted_index.biomarkers	6, 23, 139
abstract_inverted_index.classified	177
abstract_inverted_index.conversion	123
abstract_inverted_index.diagnosis.	14
abstract_inverted_index.disorders,	90
abstract_inverted_index.explaining	216
abstract_inverted_index.identified	209
abstract_inverted_index.identifies	102
abstract_inverted_index.predicting	263
abstract_inverted_index.reflecting	109
abstract_inverted_index.structural	104, 229
abstract_inverted_index.undergoing	167
abstract_inverted_index.Alzheimer's	62
abstract_inverted_index.TBM-derived	137
abstract_inverted_index.TBMSYNSCOR,	215
abstract_inverted_index.TBMSYNSCOR.	205
abstract_inverted_index.biomarkers.	74
abstract_inverted_index.cognitively	180
abstract_inverted_index.correlation	199
abstract_inverted_index.demonstrate	237
abstract_inverted_index.differences	105
abstract_inverted_index.individuals	149
abstract_inverted_index.procedures.	170
abstract_inverted_index.significant	197, 212
abstract_inverted_index.variability	220
abstract_inverted_index.highlighting	222
abstract_inverted_index.participants	175, 192
abstract_inverted_index.relationship	135
abstract_inverted_index.significantly	7, 255
abstract_inverted_index.differentiates	78
abstract_inverted_index.dysmetabolism.	30
abstract_inverted_index.neurodegenerative	81, 89
abstract_inverted_index.<bold>Methods</bold>:	154
abstract_inverted_index.<bold>Results</bold>:	187
abstract_inverted_index.<title>Abstract</title>	0
abstract_inverted_index.<bold>Background</bold>:	1
abstract_inverted_index.<bold>Conclusion</bold>:	234
cited_by_percentile_year
countries_distinct_count	2
institutions_distinct_count	13
citation_normalized_percentile.value	0.51268741
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False