Ten‐Year Clinical Outcomes of Biodegradable Versus Durable Polymer New‐Generation Drug‐Eluting Stent in Patients With Coronary Artery Disease With and Without Diabetes Mellitus Article Swipe
Tobias Lenz
,
Tobias Koch
,
Michael Joner
,
Erion Xhepa
,
Jens Wiebe
,
J J Coughlan
,
Alp Aytekin
,
Tareq Ibrahim
,
Massimiliano Fusaro
,
Salvatore Cassese
,
Karl‐Ludwig Laugwitz
,
Heribert Schunkert
,
Adnan Kastrati
,
Sebastian Kufner
,
Robert A. Byrne
,
Steffen Maßberg
,
K. Anette Birkmeier
,
S. Schulz
,
Jürgen Pache
,
Melchior Seyfarth
,
Julinda Mehilli
,
Albert Schömig
,
Petra Hoppmann
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1161/jaha.120.020165
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1161/jaha.120.020165
Background Extended long‐term follow‐up data of new‐generation drug‐eluting stents in patients with diabetes mellitus is scant. The aim of this study is to assess the 10‐year clinical outcome of new‐generation biodegradable polymer‐based sirolimus‐eluting stents (Yukon Choice PC) versus permanent polymer‐based everolimus‐eluting stents (XIENCE) in patients with and without diabetes mellitus. Methods and Results In a prespecified subgroup analysis, outcomes of patients with or without diabetes mellitus treated with drug‐eluting stents were compared. The primary end point of this analysis was major adverse cardiac event, the composite of death, myocardial infarction, or target lesion revascularization. The analysis includes a total of 1951 patients (560 patients with and 1391 patients without diabetes mellitus) randomized to treatment with Yukon Choice PC (n=1299) or Xience (n=652). Regarding the primary end point, at 10 years patients with diabetes mellitus showed significantly higher major adverse cardiac event rates than patients without diabetes mellitus ( P <0.001; hazard ratio [HR], 1.41; 95% CI, 1.22–1.63). There was no significant difference between patients treated with Yukon Choice PC versus Xience, neither in the subgroup of patients with ( P =0.91; HR, 1.01; 95% CI, 0.79–1.30) nor without diabetes mellitus ( P =0.50; HR, 0.94; 95% CI, 0.79–1.21). Rates of definite/probable stent thrombosis were 2.3% in patients with and 1.9% in patients without diabetes mellitus (HR, 1.27; 95% CI, 0.34–2.60; P =0.52), without significant differences between study devices. Conclusions The clinical outcome of patients with diabetes after percutaneous coronary intervention with different new‐generation drug‐eluting stents is considerably worse than that of patients without diabetes mellitus, with event rates constantly increasing out to 10 years. Registration URL: https://clinicaltrials.gov . Unique Identifier: NCT00598676.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1161/jaha.120.020165
- https://www.ahajournals.org/doi/pdf/10.1161/JAHA.120.020165
- OA Status
- gold
- Cited By
- 10
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3165140067
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3165140067Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1161/jaha.120.020165Digital Object Identifier
- Title
-
Ten‐Year Clinical Outcomes of Biodegradable Versus Durable Polymer New‐Generation Drug‐Eluting Stent in Patients With Coronary Artery Disease With and Without Diabetes MellitusWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-06-02Full publication date if available
- Authors
-
Tobias Lenz, Tobias Koch, Michael Joner, Erion Xhepa, Jens Wiebe, J J Coughlan, Alp Aytekin, Tareq Ibrahim, Massimiliano Fusaro, Salvatore Cassese, Karl‐Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati, Sebastian Kufner, Robert A. Byrne, Steffen Maßberg, K. Anette Birkmeier, S. Schulz, Jürgen Pache, Melchior Seyfarth, Julinda Mehilli, Albert Schömig, Petra HoppmannList of authors in order
- Landing page
-
https://doi.org/10.1161/jaha.120.020165Publisher landing page
- PDF URL
-
https://www.ahajournals.org/doi/pdf/10.1161/JAHA.120.020165Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.ahajournals.org/doi/pdf/10.1161/JAHA.120.020165Direct OA link when available
- Concepts
-
Medicine, Diabetes mellitus, Internal medicine, Hazard ratio, Stent, Myocardial infarction, Coronary artery disease, Surgery, Clinical endpoint, Drug-eluting stent, Adverse effect, Type 2 Diabetes Mellitus, Percutaneous coronary intervention, Randomized controlled trial, Confidence interval, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 4, 2023: 3, 2022: 1, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
27Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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