Teratoma Growth Retardation by HDACi Treatment of the Tumor Embryonal Source Article Swipe
Jure Krasić
,
Lucija Škara
,
Monika Ulamec
,
Ana Katušić Bojanac
,
Sanja Dabelić
,
Floriana Bulić‐Jakuš
,
Davor Ježek
,
Nino Sinčić
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/cancers12113416
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/cancers12113416
Among testicular germ cell tumors, teratomas may often be very aggressive and therapy-resistant. Our aim was to investigate the impact of histone deacetylase inhibitors (HDACi) on the in vitro growth of experimental mouse teratoma by treating their embryonic source, the embryo-proper, composed only of the three germ layers. The growth of teratomas was measured for seven days, and histopathological analysis, IHC/morphometry quantification, gene enrichment analysis, and qPCR analysis on a selected panel of pluripotency and early differentiation genes followed. For the first time, within teratomas, we histopathologically assessed the undifferentiated component containing cancer stem cell-like cells (CSCLCs) and differentiated components containing numerous lymphocytes. Mitotic indices were higher than apoptotic indices in both components. Both HDACi treatments of the embryos-proper significantly reduced teratoma growth, although this could be related neither to apoptosis nor proliferation. Trichostatin A increased the amount of CSCLCs, and upregulated the mRNA expression of pluripotency/stemness genes as well as differentiation genes, e.g., T and Eomes. Valproate decreased the amount of CSCLCs, and downregulated the expressions of pluripotency/stemness and differentiation genes. In conclusion, both HDACi treatments diminished the inherent tumorigenic growth potential of the tumor embryonal source, although Trichostatin A did not diminish the potentially dangerous expression of cancer-related genes and the amount of CSCLC.
Related Topics
Concepts
Trichostatin A
Biology
Embryonic stem cell
Cancer research
Teratoma
Cellular differentiation
Histone deacetylase
Germ cell
Cell biology
Histone
Pathology
Gene
Genetics
Medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers12113416
- https://www.mdpi.com/2072-6694/12/11/3416/pdf?version=1605685192
- OA Status
- gold
- Cited By
- 7
- References
- 105
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3098865630
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3098865630Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cancers12113416Digital Object Identifier
- Title
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Teratoma Growth Retardation by HDACi Treatment of the Tumor Embryonal SourceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-11-18Full publication date if available
- Authors
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Jure Krasić, Lucija Škara, Monika Ulamec, Ana Katušić Bojanac, Sanja Dabelić, Floriana Bulić‐Jakuš, Davor Ježek, Nino SinčićList of authors in order
- Landing page
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https://doi.org/10.3390/cancers12113416Publisher landing page
- PDF URL
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https://www.mdpi.com/2072-6694/12/11/3416/pdf?version=1605685192Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2072-6694/12/11/3416/pdf?version=1605685192Direct OA link when available
- Concepts
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Trichostatin A, Biology, Embryonic stem cell, Cancer research, Teratoma, Cellular differentiation, Histone deacetylase, Germ cell, Cell biology, Histone, Pathology, Gene, Genetics, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1, 2023: 1, 2022: 4Per-year citation counts (last 5 years)
- References (count)
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105Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I181343428 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7900000214576721 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.62875073 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |