TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism Article Swipe
Maria Zena Miranda
,
Janne Folke Bialik
,
Pam Speight
,
Qinghong Dan
,
Tony Yeung
,
Katalin Szászi
,
Stine F. Pedersen
,
András Kapùs
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1074/jbc.m117.780502
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1074/jbc.m117.780502
Hippo pathway transcriptional coactivators TAZ and YAP and the TGF-β1 (TGFβ) effector Smad3 regulate a common set of genes, can physically interact, and exhibit multilevel cross-talk regulating cell fate-determining and fibrogenic pathways. However, a key aspect of this cross-talk, TGFβ-mediated regulation of TAZ or YAP expression, remains uncharacterized. Here, we show that TGFβ induces robust TAZ but not YAP protein expression in both mesenchymal and epithelial cells. TAZ levels, and to a lesser extent YAP levels, also increased during experimental kidney fibrosis. Pharmacological or genetic inhibition of Smad3 did not prevent the TGFβ-induced TAZ up-regulation, indicating that this canonical pathway is dispensable. In contrast, inhibition of p38 MAPK, its downstream effector MK2 (e.g. by the clinically approved antifibrotic pirferidone), or Akt suppressed the TGFβ-induced TAZ expression. Moreover, TGFβ elevated TAZ mRNA in a p38-dependent manner. Myocardin-related transcription factor (MRTF) was a central mediator of this effect, as MRTF silencing/inhibition abolished the TGFβ-induced TAZ expression. MRTF overexpression drove the TAZ promoter in a CC(A/T-rich)6GG (CArG) box-dependent manner and induced TAZ protein expression. TGFβ did not act by promoting nuclear MRTF translocation; instead, it triggered p38- and MK2-mediated, Nox4-promoted MRTF phosphorylation and activation. Functionally, higher TAZ levels increased TAZ/TEAD-dependent transcription and primed cells for enhanced TAZ activity upon a second stimulus (i.e. sphingosine 1-phosphate) that induced nuclear TAZ translocation. In conclusion, our results uncover an important aspect of the cross-talk between TGFβ and Hippo signaling, showing that TGFβ induces TAZ via a Smad3-independent, p38- and MRTF-mediated and yet MRTF translocation-independent mechanism.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1074/jbc.m117.780502
- http://www.jbc.org/article/S0021925820343131/pdf
- OA Status
- hybrid
- Cited By
- 90
- References
- 88
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2737033892
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2737033892Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1074/jbc.m117.780502Digital Object Identifier
- Title
-
TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanismWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-07-25Full publication date if available
- Authors
-
Maria Zena Miranda, Janne Folke Bialik, Pam Speight, Qinghong Dan, Tony Yeung, Katalin Szászi, Stine F. Pedersen, András KapùsList of authors in order
- Landing page
-
https://doi.org/10.1074/jbc.m117.780502Publisher landing page
- PDF URL
-
https://www.jbc.org/article/S0021925820343131/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.jbc.org/article/S0021925820343131/pdfDirect OA link when available
- Concepts
-
Cell biology, Hippo signaling pathway, Gene silencing, Myocardin, Transcription factor, SMAD, Effector, Biology, Phosphorylation, Transforming growth factor, Signal transduction, Cancer research, Chemistry, Serum response factor, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
90Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 9, 2024: 17, 2023: 8, 2022: 8, 2021: 14Per-year citation counts (last 5 years)
- References (count)
-
88Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2737033892 |
|---|---|
| doi | https://doi.org/10.1074/jbc.m117.780502 |
| ids.doi | https://doi.org/10.1074/jbc.m117.780502 |
| ids.mag | 2737033892 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/28739802 |
| ids.openalex | https://openalex.org/W2737033892 |
| fwci | 4.79235284 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000217 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Acyltransferases |
| mesh[1].qualifier_ui | Q000235 |
| mesh[1].descriptor_ui | D048868 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | genetics |
| mesh[1].descriptor_name | Adaptor Proteins, Signal Transducing |
| mesh[2].qualifier_ui | Q000378 |
| mesh[2].descriptor_ui | D048868 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | metabolism |
| mesh[2].descriptor_name | Adaptor Proteins, Signal Transducing |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D000818 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Animals |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D018797 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Cell Cycle Proteins |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D002478 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Cells, Cultured |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D051379 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Mice |
| mesh[7].qualifier_ui | Q000235 |
| mesh[7].descriptor_ui | D010750 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | genetics |
| mesh[7].descriptor_name | Phosphoproteins |
| mesh[8].qualifier_ui | Q000378 |
| mesh[8].descriptor_ui | D010750 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | metabolism |
| mesh[8].descriptor_name | Phosphoproteins |
| mesh[9].qualifier_ui | Q000235 |
| mesh[9].descriptor_ui | D012333 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | genetics |
| mesh[9].descriptor_name | RNA, Messenger |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D012333 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | RNA, Messenger |
| mesh[11].qualifier_ui | Q000378 |
| mesh[11].descriptor_ui | D051900 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | metabolism |
| mesh[11].descriptor_name | Smad3 Protein |
| mesh[12].qualifier_ui | Q000378 |
| mesh[12].descriptor_ui | D015534 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | metabolism |
| mesh[12].descriptor_name | Trans-Activators |
| mesh[13].qualifier_ui | Q000235 |
| mesh[13].descriptor_ui | D014157 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | genetics |
| mesh[13].descriptor_name | Transcription Factors |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D014157 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | Transcription Factors |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D053773 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Transforming Growth Factor beta1 |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D000091102 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | YAP-Signaling Proteins |
| mesh[17].qualifier_ui | Q000037 |
| mesh[17].descriptor_ui | D048051 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | antagonists & inhibitors |
| mesh[17].descriptor_name | p38 Mitogen-Activated Protein Kinases |
| mesh[18].qualifier_ui | Q000378 |
| mesh[18].descriptor_ui | D048051 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | metabolism |
| mesh[18].descriptor_name | p38 Mitogen-Activated Protein Kinases |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D000217 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Acyltransferases |
| mesh[20].qualifier_ui | Q000235 |
| mesh[20].descriptor_ui | D048868 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | genetics |
| mesh[20].descriptor_name | Adaptor Proteins, Signal Transducing |
| mesh[21].qualifier_ui | Q000378 |
| mesh[21].descriptor_ui | D048868 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | metabolism |
| mesh[21].descriptor_name | Adaptor Proteins, Signal Transducing |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D000818 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Animals |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D018797 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Cell Cycle Proteins |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D002478 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Cells, Cultured |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D051379 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Mice |
| mesh[26].qualifier_ui | Q000235 |
| mesh[26].descriptor_ui | D010750 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | genetics |
| mesh[26].descriptor_name | Phosphoproteins |
| mesh[27].qualifier_ui | Q000378 |
| mesh[27].descriptor_ui | D010750 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | metabolism |
| mesh[27].descriptor_name | Phosphoproteins |
| mesh[28].qualifier_ui | Q000235 |
| mesh[28].descriptor_ui | D012333 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | genetics |
| mesh[28].descriptor_name | RNA, Messenger |
| mesh[29].qualifier_ui | Q000378 |
| mesh[29].descriptor_ui | D012333 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | metabolism |
| mesh[29].descriptor_name | RNA, Messenger |
| mesh[30].qualifier_ui | Q000378 |
| mesh[30].descriptor_ui | D051900 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | metabolism |
| mesh[30].descriptor_name | Smad3 Protein |
| mesh[31].qualifier_ui | Q000378 |
| mesh[31].descriptor_ui | D015534 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | metabolism |
| mesh[31].descriptor_name | Trans-Activators |
| mesh[32].qualifier_ui | Q000235 |
| mesh[32].descriptor_ui | D014157 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | genetics |
| mesh[32].descriptor_name | Transcription Factors |
| mesh[33].qualifier_ui | Q000378 |
| mesh[33].descriptor_ui | D014157 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | metabolism |
| mesh[33].descriptor_name | Transcription Factors |
| mesh[34].qualifier_ui | Q000378 |
| mesh[34].descriptor_ui | D053773 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | metabolism |
| mesh[34].descriptor_name | Transforming Growth Factor beta1 |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D000091102 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | YAP-Signaling Proteins |
| mesh[36].qualifier_ui | Q000037 |
| mesh[36].descriptor_ui | D048051 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | antagonists & inhibitors |
| mesh[36].descriptor_name | p38 Mitogen-Activated Protein Kinases |
| mesh[37].qualifier_ui | Q000378 |
| mesh[37].descriptor_ui | D048051 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | metabolism |
| mesh[37].descriptor_name | p38 Mitogen-Activated Protein Kinases |
| type | article |
| title | TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism |
| awards[0].id | https://openalex.org/G3927928814 |
| awards[0].funder_id | https://openalex.org/F4320334593 |
| awards[0].funder_award_id | RGPIN227-908-13 |
| awards[0].funder_display_name | Natural Sciences and Engineering Research Council of Canada |
| awards[1].id | https://openalex.org/G1132019080 |
| awards[1].funder_id | https://openalex.org/F4320334506 |
| awards[1].funder_award_id | MOP-106625 |
| awards[1].funder_display_name | Canadian Institutes of Health Research |
| awards[2].id | https://openalex.org/G3073422570 |
| awards[2].funder_id | https://openalex.org/F4320334506 |
| awards[2].funder_award_id | MOP-130463 |
| awards[2].funder_display_name | Canadian Institutes of Health Research |
| awards[3].id | https://openalex.org/G6402290020 |
| awards[3].funder_id | https://openalex.org/F4320334593 |
| awards[3].funder_award_id | RGPIN 327407 |
| awards[3].funder_display_name | Natural Sciences and Engineering Research Council of Canada |
| biblio.issue | 36 |
| biblio.volume | 292 |
| biblio.last_page | 14920 |
| biblio.first_page | 14902 |
| grants[0].funder | https://openalex.org/F4320319947 |
| grants[0].award_id | |
| grants[0].funder_display_name | Kidney Foundation of Canada |
| grants[1].funder | https://openalex.org/F4320334506 |
| grants[1].award_id | MOP-106625 |
| grants[1].funder_display_name | Canadian Institutes of Health Research |
| grants[2].funder | https://openalex.org/F4320334506 |
| grants[2].award_id | MOP-130463 |
| grants[2].funder_display_name | Canadian Institutes of Health Research |
| grants[3].funder | https://openalex.org/F4320334593 |
| grants[3].award_id | RGPIN 327407 |
| grants[3].funder_display_name | Natural Sciences and Engineering Research Council of Canada |
| grants[4].funder | https://openalex.org/F4320334593 |
| grants[4].award_id | RGPIN227-908-13 |
| grants[4].funder_display_name | Natural Sciences and Engineering Research Council of Canada |
| topics[0].id | https://openalex.org/T12065 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1307 |
| topics[0].subfield.display_name | Cell Biology |
| topics[0].display_name | Hippo pathway signaling and YAP/TAZ |
| topics[1].id | https://openalex.org/T10929 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9089000225067139 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Wnt/β-catenin signaling in development and cancer |
| funders[0].id | https://openalex.org/F4320319947 |
| funders[0].ror | https://ror.org/019a0gk53 |
| funders[0].display_name | Kidney Foundation of Canada |
| funders[1].id | https://openalex.org/F4320332432 |
| funders[1].ror | https://ror.org/02vm5rt34 |
| funders[1].display_name | School of Medicine, Vanderbilt University |
| funders[2].id | https://openalex.org/F4320334506 |
| funders[2].ror | https://ror.org/01gavpb45 |
| funders[2].display_name | Canadian Institutes of Health Research |
| funders[3].id | https://openalex.org/F4320334593 |
| funders[3].ror | https://ror.org/01h531d29 |
| funders[3].display_name | Natural Sciences and Engineering Research Council of Canada |
| is_xpac | False |
| apc_list.value | 2500 |
| apc_list.currency | USD |
| apc_list.value_usd | 2500 |
| apc_paid.value | 2500 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2500 |
| concepts[0].id | https://openalex.org/C95444343 |
| concepts[0].level | 1 |
| concepts[0].score | 0.6396868228912354 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[0].display_name | Cell biology |
| concepts[1].id | https://openalex.org/C172512520 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6346279978752136 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q5768379 |
| concepts[1].display_name | Hippo signaling pathway |
| concepts[2].id | https://openalex.org/C119056186 |
| concepts[2].level | 3 |
| concepts[2].score | 0.627065122127533 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1431332 |
| concepts[2].display_name | Gene silencing |
| concepts[3].id | https://openalex.org/C2780286377 |
| concepts[3].level | 5 |
| concepts[3].score | 0.6237215995788574 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q18048730 |
| concepts[3].display_name | Myocardin |
| concepts[4].id | https://openalex.org/C86339819 |
| concepts[4].level | 3 |
| concepts[4].score | 0.6100286245346069 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q407384 |
| concepts[4].display_name | Transcription factor |
| concepts[5].id | https://openalex.org/C2781080636 |
| concepts[5].level | 3 |
| concepts[5].score | 0.6036338806152344 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q700000 |
| concepts[5].display_name | SMAD |
| concepts[6].id | https://openalex.org/C51785407 |
| concepts[6].level | 2 |
| concepts[6].score | 0.602527379989624 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2627568 |
| concepts[6].display_name | Effector |
| concepts[7].id | https://openalex.org/C86803240 |
| concepts[7].level | 0 |
| concepts[7].score | 0.5484344959259033 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[7].display_name | Biology |
| concepts[8].id | https://openalex.org/C11960822 |
| concepts[8].level | 2 |
| concepts[8].score | 0.48022112250328064 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q242736 |
| concepts[8].display_name | Phosphorylation |
| concepts[9].id | https://openalex.org/C118131993 |
| concepts[9].level | 2 |
| concepts[9].score | 0.41818472743034363 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q423671 |
| concepts[9].display_name | Transforming growth factor |
| concepts[10].id | https://openalex.org/C62478195 |
| concepts[10].level | 2 |
| concepts[10].score | 0.4116542637348175 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q828130 |
| concepts[10].display_name | Signal transduction |
| concepts[11].id | https://openalex.org/C502942594 |
| concepts[11].level | 1 |
| concepts[11].score | 0.3515358567237854 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[11].display_name | Cancer research |
| concepts[12].id | https://openalex.org/C185592680 |
| concepts[12].level | 0 |
| concepts[12].score | 0.32673531770706177 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[12].display_name | Chemistry |
| concepts[13].id | https://openalex.org/C69053785 |
| concepts[13].level | 4 |
| concepts[13].score | 0.30105313658714294 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q907394 |
| concepts[13].display_name | Serum response factor |
| concepts[14].id | https://openalex.org/C104317684 |
| concepts[14].level | 2 |
| concepts[14].score | 0.16604438424110413 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[14].display_name | Gene |
| concepts[15].id | https://openalex.org/C54355233 |
| concepts[15].level | 1 |
| concepts[15].score | 0.08289161324501038 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[15].display_name | Genetics |
| keywords[0].id | https://openalex.org/keywords/cell-biology |
| keywords[0].score | 0.6396868228912354 |
| keywords[0].display_name | Cell biology |
| keywords[1].id | https://openalex.org/keywords/hippo-signaling-pathway |
| keywords[1].score | 0.6346279978752136 |
| keywords[1].display_name | Hippo signaling pathway |
| keywords[2].id | https://openalex.org/keywords/gene-silencing |
| keywords[2].score | 0.627065122127533 |
| keywords[2].display_name | Gene silencing |
| keywords[3].id | https://openalex.org/keywords/myocardin |
| keywords[3].score | 0.6237215995788574 |
| keywords[3].display_name | Myocardin |
| keywords[4].id | https://openalex.org/keywords/transcription-factor |
| keywords[4].score | 0.6100286245346069 |
| keywords[4].display_name | Transcription factor |
| keywords[5].id | https://openalex.org/keywords/smad |
| keywords[5].score | 0.6036338806152344 |
| keywords[5].display_name | SMAD |
| keywords[6].id | https://openalex.org/keywords/effector |
| keywords[6].score | 0.602527379989624 |
| keywords[6].display_name | Effector |
| keywords[7].id | https://openalex.org/keywords/biology |
| keywords[7].score | 0.5484344959259033 |
| keywords[7].display_name | Biology |
| keywords[8].id | https://openalex.org/keywords/phosphorylation |
| keywords[8].score | 0.48022112250328064 |
| keywords[8].display_name | Phosphorylation |
| keywords[9].id | https://openalex.org/keywords/transforming-growth-factor |
| keywords[9].score | 0.41818472743034363 |
| keywords[9].display_name | Transforming growth factor |
| keywords[10].id | https://openalex.org/keywords/signal-transduction |
| keywords[10].score | 0.4116542637348175 |
| keywords[10].display_name | Signal transduction |
| keywords[11].id | https://openalex.org/keywords/cancer-research |
| keywords[11].score | 0.3515358567237854 |
| keywords[11].display_name | Cancer research |
| keywords[12].id | https://openalex.org/keywords/chemistry |
| keywords[12].score | 0.32673531770706177 |
| keywords[12].display_name | Chemistry |
| keywords[13].id | https://openalex.org/keywords/serum-response-factor |
| keywords[13].score | 0.30105313658714294 |
| keywords[13].display_name | Serum response factor |
| keywords[14].id | https://openalex.org/keywords/gene |
| keywords[14].score | 0.16604438424110413 |
| keywords[14].display_name | Gene |
| keywords[15].id | https://openalex.org/keywords/genetics |
| keywords[15].score | 0.08289161324501038 |
| keywords[15].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.1074/jbc.m117.780502 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S140251998 |
| locations[0].source.issn | 0021-9258, 1067-8816, 1083-351X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0021-9258 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Journal of Biological Chemistry |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].license | cc-by |
| locations[0].pdf_url | http://www.jbc.org/article/S0021925820343131/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Biological Chemistry |
| locations[0].landing_page_url | https://doi.org/10.1074/jbc.m117.780502 |
| locations[1].id | pmid:28739802 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | The Journal of biological chemistry |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/28739802 |
| locations[2].id | pmh:oai:europepmc.org:5078143 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/5592669 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5036345848 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Maria Zena Miranda |
| authorships[0].countries | CA |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I1297363086 |
| authorships[0].affiliations[0].raw_affiliation_string | From the Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I185261750 |
| authorships[0].affiliations[1].raw_affiliation_string | Biochemistry, University of Toronto, Toronto, Ontario M5B 1T8N, Canada |
| authorships[0].institutions[0].id | https://openalex.org/I1297363086 |
| authorships[0].institutions[0].ror | https://ror.org/04skqfp25 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I1297363086, https://openalex.org/I4399598460 |
| authorships[0].institutions[0].country_code | CA |
| authorships[0].institutions[0].display_name | St. Michael's Hospital |
| authorships[0].institutions[1].id | https://openalex.org/I185261750 |
| authorships[0].institutions[1].ror | https://ror.org/03dbr7087 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I185261750 |
| authorships[0].institutions[1].country_code | CA |
| authorships[0].institutions[1].display_name | University of Toronto |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Maria Zena Miranda |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Biochemistry, University of Toronto, Toronto, Ontario M5B 1T8N, Canada, From the Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, |
| authorships[1].author.id | https://openalex.org/A5075363316 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-1042-8169 |
| authorships[1].author.display_name | Janne Folke Bialik |
| authorships[1].countries | CA, DK |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1297363086 |
| authorships[1].affiliations[0].raw_affiliation_string | From the Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I124055696 |
| authorships[1].affiliations[1].raw_affiliation_string | Department of Cell and Developmental Biology, University of Copenhagen, Copenhagen DK-2100, Denmark |
| authorships[1].institutions[0].id | https://openalex.org/I1297363086 |
| authorships[1].institutions[0].ror | https://ror.org/04skqfp25 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I1297363086, https://openalex.org/I4399598460 |
| authorships[1].institutions[0].country_code | CA |
| authorships[1].institutions[0].display_name | St. Michael's Hospital |
| authorships[1].institutions[1].id | https://openalex.org/I124055696 |
| authorships[1].institutions[1].ror | https://ror.org/035b05819 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I124055696 |
| authorships[1].institutions[1].country_code | DK |
| authorships[1].institutions[1].display_name | University of Copenhagen |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Janne Folke Bialik |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Cell and Developmental Biology, University of Copenhagen, Copenhagen DK-2100, Denmark, From the Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, |
| authorships[2].author.id | https://openalex.org/A5008022917 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Pam Speight |
| authorships[2].countries | CA |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1297363086 |
| authorships[2].affiliations[0].raw_affiliation_string | From the Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, |
| authorships[2].institutions[0].id | https://openalex.org/I1297363086 |
| authorships[2].institutions[0].ror | https://ror.org/04skqfp25 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I1297363086, https://openalex.org/I4399598460 |
| authorships[2].institutions[0].country_code | CA |
| authorships[2].institutions[0].display_name | St. Michael's Hospital |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Pam Speight |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | From the Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, |
| authorships[3].author.id | https://openalex.org/A5087869067 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Qinghong Dan |
| authorships[3].countries | CA |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1297363086 |
| authorships[3].affiliations[0].raw_affiliation_string | From the Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, |
| authorships[3].institutions[0].id | https://openalex.org/I1297363086 |
| authorships[3].institutions[0].ror | https://ror.org/04skqfp25 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I1297363086, https://openalex.org/I4399598460 |
| authorships[3].institutions[0].country_code | CA |
| authorships[3].institutions[0].display_name | St. Michael's Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Qinghong Dan |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | From the Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, |
| authorships[4].author.id | https://openalex.org/A5084666328 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1970-5751 |
| authorships[4].author.display_name | Tony Yeung |
| authorships[4].countries | CA |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1297363086 |
| authorships[4].affiliations[0].raw_affiliation_string | From the Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, |
| authorships[4].institutions[0].id | https://openalex.org/I1297363086 |
| authorships[4].institutions[0].ror | https://ror.org/04skqfp25 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I1297363086, https://openalex.org/I4399598460 |
| authorships[4].institutions[0].country_code | CA |
| authorships[4].institutions[0].display_name | St. Michael's Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Tony Yeung |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | From the Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, |
| authorships[5].author.id | https://openalex.org/A5086761442 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-2490-8422 |
| authorships[5].author.display_name | Katalin Szászi |
| authorships[5].countries | CA |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I1297363086 |
| authorships[5].affiliations[0].raw_affiliation_string | From the Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, |
| authorships[5].affiliations[1].raw_affiliation_string | Departments of Surgery |
| authorships[5].institutions[0].id | https://openalex.org/I1297363086 |
| authorships[5].institutions[0].ror | https://ror.org/04skqfp25 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I1297363086, https://openalex.org/I4399598460 |
| authorships[5].institutions[0].country_code | CA |
| authorships[5].institutions[0].display_name | St. Michael's Hospital |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Katalin Szászi |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Departments of Surgery, From the Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, |
| authorships[6].author.id | https://openalex.org/A5015579145 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-3044-7714 |
| authorships[6].author.display_name | Stine F. Pedersen |
| authorships[6].countries | DK |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I124055696 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Cell and Developmental Biology, University of Copenhagen, Copenhagen DK-2100, Denmark |
| authorships[6].institutions[0].id | https://openalex.org/I124055696 |
| authorships[6].institutions[0].ror | https://ror.org/035b05819 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I124055696 |
| authorships[6].institutions[0].country_code | DK |
| authorships[6].institutions[0].display_name | University of Copenhagen |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Stine F. Pedersen |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Cell and Developmental Biology, University of Copenhagen, Copenhagen DK-2100, Denmark |
| authorships[7].author.id | https://openalex.org/A5055198525 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-6610-9530 |
| authorships[7].author.display_name | András Kapùs |
| authorships[7].countries | CA |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I1297363086 |
| authorships[7].affiliations[0].raw_affiliation_string | From the Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, |
| authorships[7].affiliations[1].raw_affiliation_string | Departments of Surgery |
| authorships[7].affiliations[2].institution_ids | https://openalex.org/I185261750 |
| authorships[7].affiliations[2].raw_affiliation_string | Biochemistry, University of Toronto, Toronto, Ontario M5B 1T8N, Canada |
| authorships[7].institutions[0].id | https://openalex.org/I1297363086 |
| authorships[7].institutions[0].ror | https://ror.org/04skqfp25 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I1297363086, https://openalex.org/I4399598460 |
| authorships[7].institutions[0].country_code | CA |
| authorships[7].institutions[0].display_name | St. Michael's Hospital |
| authorships[7].institutions[1].id | https://openalex.org/I185261750 |
| authorships[7].institutions[1].ror | https://ror.org/03dbr7087 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I185261750 |
| authorships[7].institutions[1].country_code | CA |
| authorships[7].institutions[1].display_name | University of Toronto |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | András Kapus |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Biochemistry, University of Toronto, Toronto, Ontario M5B 1T8N, Canada, Departments of Surgery, From the Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | http://www.jbc.org/article/S0021925820343131/pdf |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12065 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1307 |
| primary_topic.subfield.display_name | Cell Biology |
| primary_topic.display_name | Hippo pathway signaling and YAP/TAZ |
| related_works | https://openalex.org/W2086069154, https://openalex.org/W2152376785, https://openalex.org/W2030331032, https://openalex.org/W1964820861, https://openalex.org/W2096628719, https://openalex.org/W2167746653, https://openalex.org/W2124892165, https://openalex.org/W2110743056, https://openalex.org/W3161396723, https://openalex.org/W2592054416 |
| cited_by_count | 90 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 9 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 17 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 8 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 8 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 14 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 8 |
| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 12 |
| counts_by_year[7].year | 2018 |
| counts_by_year[7].cited_by_count | 11 |
| counts_by_year[8].year | 2017 |
| counts_by_year[8].cited_by_count | 2 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1074/jbc.m117.780502 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S140251998 |
| best_oa_location.source.issn | 0021-9258, 1067-8816, 1083-351X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0021-9258 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Journal of Biological Chemistry |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | http://www.jbc.org/article/S0021925820343131/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Biological Chemistry |
| best_oa_location.landing_page_url | https://doi.org/10.1074/jbc.m117.780502 |
| primary_location.id | doi:10.1074/jbc.m117.780502 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S140251998 |
| primary_location.source.issn | 0021-9258, 1067-8816, 1083-351X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0021-9258 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Journal of Biological Chemistry |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.license | cc-by |
| primary_location.pdf_url | http://www.jbc.org/article/S0021925820343131/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Biological Chemistry |
| primary_location.landing_page_url | https://doi.org/10.1074/jbc.m117.780502 |
| publication_date | 2017-07-25 |
| publication_year | 2017 |
| referenced_works | https://openalex.org/W1995160678, https://openalex.org/W1963272969, https://openalex.org/W2161491446, https://openalex.org/W1863585495, https://openalex.org/W2426003472, https://openalex.org/W2341467683, https://openalex.org/W2129236688, https://openalex.org/W2295717665, https://openalex.org/W2401751910, https://openalex.org/W2011346718, https://openalex.org/W2168072233, https://openalex.org/W2556156445, https://openalex.org/W2208280515, https://openalex.org/W2508686416, https://openalex.org/W2223413920, https://openalex.org/W2126712555, https://openalex.org/W2167978765, https://openalex.org/W2146337514, https://openalex.org/W2061058076, https://openalex.org/W2088593944, https://openalex.org/W2093021491, https://openalex.org/W2175620885, https://openalex.org/W2003407318, https://openalex.org/W1993089065, https://openalex.org/W1929538119, https://openalex.org/W1985770572, https://openalex.org/W1964847767, https://openalex.org/W2035653659, https://openalex.org/W2099361912, https://openalex.org/W2086338128, https://openalex.org/W1982498121, https://openalex.org/W2151260549, https://openalex.org/W1976472776, https://openalex.org/W1980236812, https://openalex.org/W2006827110, https://openalex.org/W2090392605, https://openalex.org/W2093723806, https://openalex.org/W2044982400, https://openalex.org/W2052092179, https://openalex.org/W2041614750, https://openalex.org/W2119505108, https://openalex.org/W2104002497, https://openalex.org/W2129063289, https://openalex.org/W2067954451, https://openalex.org/W2056102163, https://openalex.org/W2028933149, https://openalex.org/W2009740683, https://openalex.org/W1804602290, https://openalex.org/W2114051326, https://openalex.org/W1974523661, https://openalex.org/W2340544421, https://openalex.org/W2420944975, https://openalex.org/W2487612501, https://openalex.org/W2157068896, https://openalex.org/W2476927394, https://openalex.org/W2207821817, https://openalex.org/W2162514162, https://openalex.org/W2142742192, https://openalex.org/W101515753, https://openalex.org/W2031607451, https://openalex.org/W2026733880, https://openalex.org/W2216800479, https://openalex.org/W2109838283, https://openalex.org/W2133664789, https://openalex.org/W2003349005, https://openalex.org/W2147836129, https://openalex.org/W2271598438, https://openalex.org/W2050053473, https://openalex.org/W2034616962, https://openalex.org/W1967487834, https://openalex.org/W2288707363, https://openalex.org/W2113989947, https://openalex.org/W2148392040, https://openalex.org/W2171177609, https://openalex.org/W2076597032, https://openalex.org/W2030598429, https://openalex.org/W2094536853, https://openalex.org/W2507196425, https://openalex.org/W2007308365, https://openalex.org/W1966517811, https://openalex.org/W1544611835, https://openalex.org/W2011112085, https://openalex.org/W2511468218, https://openalex.org/W1999792045, https://openalex.org/W2087073947, https://openalex.org/W2034955793, https://openalex.org/W1970195787, https://openalex.org/W2129055432 |
| referenced_works_count | 88 |
| abstract_inverted_index.a | 14, 33, 71, 132, 140, 161, 206, 239 |
| abstract_inverted_index.In | 102, 217 |
| abstract_inverted_index.an | 222 |
| abstract_inverted_index.as | 146 |
| abstract_inverted_index.by | 113, 175 |
| abstract_inverted_index.in | 61, 131, 160 |
| abstract_inverted_index.is | 100 |
| abstract_inverted_index.it | 181 |
| abstract_inverted_index.of | 17, 36, 41, 86, 105, 143, 225 |
| abstract_inverted_index.or | 43, 83, 119 |
| abstract_inverted_index.to | 70 |
| abstract_inverted_index.we | 49 |
| abstract_inverted_index.Akt | 120 |
| abstract_inverted_index.MK2 | 111 |
| abstract_inverted_index.TAZ | 4, 42, 55, 67, 93, 124, 129, 152, 158, 168, 193, 203, 215, 237 |
| abstract_inverted_index.YAP | 6, 44, 58, 74 |
| abstract_inverted_index.act | 174 |
| abstract_inverted_index.and | 5, 7, 22, 29, 64, 69, 166, 184, 189, 198, 230, 242, 244 |
| abstract_inverted_index.but | 56 |
| abstract_inverted_index.can | 19 |
| abstract_inverted_index.did | 88, 172 |
| abstract_inverted_index.for | 201 |
| abstract_inverted_index.its | 108 |
| abstract_inverted_index.key | 34 |
| abstract_inverted_index.not | 57, 89, 173 |
| abstract_inverted_index.our | 219 |
| abstract_inverted_index.p38 | 106 |
| abstract_inverted_index.set | 16 |
| abstract_inverted_index.the | 8, 91, 114, 122, 150, 157, 226 |
| abstract_inverted_index.via | 238 |
| abstract_inverted_index.was | 139 |
| abstract_inverted_index.yet | 245 |
| abstract_inverted_index.MRTF | 147, 154, 178, 187, 246 |
| abstract_inverted_index.also | 76 |
| abstract_inverted_index.both | 62 |
| abstract_inverted_index.cell | 27 |
| abstract_inverted_index.mRNA | 130 |
| abstract_inverted_index.p38- | 183, 241 |
| abstract_inverted_index.show | 50 |
| abstract_inverted_index.that | 51, 96, 212, 234 |
| abstract_inverted_index.this | 37, 97, 144 |
| abstract_inverted_index.upon | 205 |
| abstract_inverted_index.Here, | 48 |
| abstract_inverted_index.Hippo | 0, 231 |
| abstract_inverted_index.MAPK, | 107 |
| abstract_inverted_index.Smad3 | 12, 87 |
| abstract_inverted_index.TGFβ | 52, 127, 171, 229, 235 |
| abstract_inverted_index.cells | 200 |
| abstract_inverted_index.drove | 156 |
| abstract_inverted_index.(CArG) | 163 |
| abstract_inverted_index.(MRTF) | 138 |
| abstract_inverted_index.aspect | 35, 224 |
| abstract_inverted_index.cells. | 66 |
| abstract_inverted_index.common | 15 |
| abstract_inverted_index.during | 78 |
| abstract_inverted_index.extent | 73 |
| abstract_inverted_index.factor | 137 |
| abstract_inverted_index.genes, | 18 |
| abstract_inverted_index.higher | 192 |
| abstract_inverted_index.kidney | 80 |
| abstract_inverted_index.lesser | 72 |
| abstract_inverted_index.levels | 194 |
| abstract_inverted_index.manner | 165 |
| abstract_inverted_index.primed | 199 |
| abstract_inverted_index.robust | 54 |
| abstract_inverted_index.second | 207 |
| abstract_inverted_index.(TGFβ) | 10 |
| abstract_inverted_index.TGF-β1 | 9 |
| abstract_inverted_index.between | 228 |
| abstract_inverted_index.central | 141 |
| abstract_inverted_index.effect, | 145 |
| abstract_inverted_index.exhibit | 23 |
| abstract_inverted_index.genetic | 84 |
| abstract_inverted_index.induced | 167, 213 |
| abstract_inverted_index.induces | 53, 236 |
| abstract_inverted_index.levels, | 68, 75 |
| abstract_inverted_index.manner. | 134 |
| abstract_inverted_index.nuclear | 177, 214 |
| abstract_inverted_index.pathway | 1, 99 |
| abstract_inverted_index.prevent | 90 |
| abstract_inverted_index.protein | 59, 169 |
| abstract_inverted_index.remains | 46 |
| abstract_inverted_index.results | 220 |
| abstract_inverted_index.showing | 233 |
| abstract_inverted_index.uncover | 221 |
| abstract_inverted_index.However, | 32 |
| abstract_inverted_index.activity | 204 |
| abstract_inverted_index.approved | 116 |
| abstract_inverted_index.effector | 11, 110 |
| abstract_inverted_index.elevated | 128 |
| abstract_inverted_index.enhanced | 202 |
| abstract_inverted_index.instead, | 180 |
| abstract_inverted_index.mediator | 142 |
| abstract_inverted_index.promoter | 159 |
| abstract_inverted_index.regulate | 13 |
| abstract_inverted_index.stimulus | 208 |
| abstract_inverted_index.Moreover, | 126 |
| abstract_inverted_index.abolished | 149 |
| abstract_inverted_index.canonical | 98 |
| abstract_inverted_index.contrast, | 103 |
| abstract_inverted_index.fibrosis. | 81 |
| abstract_inverted_index.important | 223 |
| abstract_inverted_index.increased | 77, 195 |
| abstract_inverted_index.interact, | 21 |
| abstract_inverted_index.pathways. | 31 |
| abstract_inverted_index.promoting | 176 |
| abstract_inverted_index.triggered | 182 |
| abstract_inverted_index.clinically | 115 |
| abstract_inverted_index.cross-talk | 25, 227 |
| abstract_inverted_index.downstream | 109 |
| abstract_inverted_index.epithelial | 65 |
| abstract_inverted_index.expression | 60 |
| abstract_inverted_index.fibrogenic | 30 |
| abstract_inverted_index.indicating | 95 |
| abstract_inverted_index.inhibition | 85, 104 |
| abstract_inverted_index.mechanism. | 248 |
| abstract_inverted_index.multilevel | 24 |
| abstract_inverted_index.physically | 20 |
| abstract_inverted_index.regulating | 26 |
| abstract_inverted_index.regulation | 40 |
| abstract_inverted_index.signaling, | 232 |
| abstract_inverted_index.suppressed | 121 |
| abstract_inverted_index.activation. | 190 |
| abstract_inverted_index.conclusion, | 218 |
| abstract_inverted_index.cross-talk, | 38 |
| abstract_inverted_index.expression, | 45 |
| abstract_inverted_index.expression. | 125, 153, 170 |
| abstract_inverted_index.mesenchymal | 63 |
| abstract_inverted_index.sphingosine | 210 |
| abstract_inverted_index.(<i>e.g.</i> | 112 |
| abstract_inverted_index.(<i>i.e.</i> | 209 |
| abstract_inverted_index.1-phosphate) | 211 |
| abstract_inverted_index.antifibrotic | 117 |
| abstract_inverted_index.coactivators | 3 |
| abstract_inverted_index.dispensable. | 101 |
| abstract_inverted_index.experimental | 79 |
| abstract_inverted_index.Functionally, | 191 |
| abstract_inverted_index.MK2-mediated, | 185 |
| abstract_inverted_index.MRTF-mediated | 243 |
| abstract_inverted_index.Nox4-promoted | 186 |
| abstract_inverted_index.TGFβ-induced | 92, 123, 151 |
| abstract_inverted_index.box-dependent | 164 |
| abstract_inverted_index.p38-dependent | 133 |
| abstract_inverted_index.pirferidone), | 118 |
| abstract_inverted_index.transcription | 136, 197 |
| abstract_inverted_index.TGFβ-mediated | 39 |
| abstract_inverted_index.overexpression | 155 |
| abstract_inverted_index.translocation. | 216 |
| abstract_inverted_index.translocation; | 179 |
| abstract_inverted_index.up-regulation, | 94 |
| abstract_inverted_index.Pharmacological | 82 |
| abstract_inverted_index.phosphorylation | 188 |
| abstract_inverted_index.transcriptional | 2 |
| abstract_inverted_index.fate-determining | 28 |
| abstract_inverted_index.uncharacterized. | 47 |
| abstract_inverted_index.Myocardin-related | 135 |
| abstract_inverted_index.Smad3-independent, | 240 |
| abstract_inverted_index.TAZ/TEAD-dependent | 196 |
| abstract_inverted_index.silencing/inhibition | 148 |
| abstract_inverted_index.translocation-independent | 247 |
| abstract_inverted_index.CC(A/T-rich)<sub>6</sub>GG | 162 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5055198525 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I1297363086, https://openalex.org/I185261750 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.94715322 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |