TGFβ-Signaling and FOXG1-Expression Are a Hallmark of Astrocyte Lineage Diversity in the Murine Ventral and Dorsal Forebrain Article Swipe
Stefan Weise
,
Alejandro Villarreal
,
Stefanie Heidrich
,
Fariba Dehghanian
,
Christian Schachtrup
,
Sigrun Nestel
,
J. M. Schwarz
,
Kathrin Thedieck
,
Tanja Vogel
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3389/fncel.2018.00448
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3389/fncel.2018.00448
Heterogeneous astrocyte populations are defined by diversity in cellular environment, progenitor identity or function. Yet, little is known about the extent of the heterogeneity and how this diversity is acquired during development. To investigate the impact of TGF (transforming growth factor) β-signaling on astrocyte development in the telencephalon we deleted the TGFBR2 (transforming growth factor beta receptor 2) in early neural progenitor cells in mice using a FOXG1 (forkhead box G1)-driven CRE-recombinase. We used quantitative proteomics to characterize TGFBR2-deficient cells derived from the mouse telencephalon and identified differential protein expression of the astrocyte proteins GFAP (glial fibrillary acidic protein) and MFGE8 (milk fat globule-EGF factor 8). Biochemical and histological investigations revealed distinct populations of astrocytes in the dorsal and ventral telencephalon marked by GFAP or MFGE8 protein expression. The two subtypes differed in their response to TGFβ-signaling. Impaired TGFβ-signaling affected numbers of GFAP astrocytes in the ventral telencephalon. In contrast, TGFβ reduced MFGE8-expression in astrocytes deriving from both regions. Additionally, lineage tracing revealed that both GFAP and MFGE8 astrocyte subtypes derived partly from FOXG1-expressing neural precursor cells.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fncel.2018.00448
- OA Status
- gold
- Cited By
- 10
- References
- 79
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2903365961
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2903365961Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fncel.2018.00448Digital Object Identifier
- Title
-
TGFβ-Signaling and FOXG1-Expression Are a Hallmark of Astrocyte Lineage Diversity in the Murine Ventral and Dorsal ForebrainWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2018Year of publication
- Publication date
-
2018-11-28Full publication date if available
- Authors
-
Stefan Weise, Alejandro Villarreal, Stefanie Heidrich, Fariba Dehghanian, Christian Schachtrup, Sigrun Nestel, J. M. Schwarz, Kathrin Thedieck, Tanja VogelList of authors in order
- Landing page
-
https://doi.org/10.3389/fncel.2018.00448Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fncel.2018.00448Direct OA link when available
- Concepts
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Forebrain, Astrocyte, Dorsum, Neuroscience, Lineage (genetic), Biology, Cell biology, Transforming growth factor, Anatomy, Central nervous system, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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10Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2023: 1, 2022: 2, 2021: 4, 2020: 1Per-year citation counts (last 5 years)
- References (count)
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79Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| citation_normalized_percentile.value | 0.66162431 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |