Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10 Article Swipe
Melba Muñoz
,
Ahmed N. Hegazy
,
Tobias M. Brunner
,
Vivien Holecska
,
Roman Marek
,
Anja Fröhlich
,
Max Löhning
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2002787118
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2002787118
Significance Strategies to suppress memory T cell responses are needed. Th2-polarized cells lacking the transcription factor T-bet strongly suppress not only naive but also memory T cell responses via IL-10 and protect mice against the development of virus-induced type 1 diabetes. We shed light on a population of immune cells with substantial immunomodulatory capacity.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.2002787118
- OA Status
- green
- Cited By
- 14
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3126715076
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3126715076Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1073/pnas.2002787118Digital Object Identifier
- Title
-
Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-02-01Full publication date if available
- Authors
-
Melba Muñoz, Ahmed N. Hegazy, Tobias M. Brunner, Vivien Holecska, Roman Marek, Anja Fröhlich, Max LöhningList of authors in order
- Landing page
-
https://doi.org/10.1073/pnas.2002787118Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/8017670Direct OA link when available
- Concepts
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Immune system, Biology, T cell, Population, Immunology, Transcription factor, Cell biology, Cell, Memory T cell, Medicine, Genetics, Gene, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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14Total citation count in OpenAlex
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2025: 4, 2024: 1, 2023: 4, 2022: 3, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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66Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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| referenced_works_count | 66 |
| abstract_inverted_index.1 | 39 |
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| abstract_inverted_index.but | 22 |
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| abstract_inverted_index.T-bet | 16 |
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| abstract_inverted_index.memory | 4, 24 |
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| abstract_inverted_index.immunomodulatory | 52 |
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| corresponding_author_ids | https://openalex.org/A5009054700, https://openalex.org/A5028911763, https://openalex.org/A5059225038 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I4210095248, https://openalex.org/I4210139777, https://openalex.org/I7877124 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7400000095367432 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.84894993 |
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| citation_normalized_percentile.is_in_top_10_percent | False |