The 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian Hospital Article Swipe
Roberta Fachini
,
Rita Fontão‐Wendel
,
Ruth Achkar
,
Patrícia Scuracchio
,
Mayra Brito
,
Marcelo Amaral
,
Silvano Wendel
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/pathogens10111499
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/pathogens10111499
(1) Background: We reviewed the logistics of the implementation of pathogen reduction (PR) using the INTERCEPT Blood System™ for platelets and the experience with routine use and clinical outcomes in the patient population at the Sírio-Libanês Hospital of São Paulo, Brazil. (2) Methods: Platelet concentrate (PC), including pathogen reduced (PR-PC) production, inventory management, discard rates, blood utilization, and clinical outcomes were analyzed over the 40 months before and after PR implementation. Age distribution and wastage rates were compared over the 10 months before and after approval for PR-PC to be stored for up to seven days. (3) Results: A 100% PR-PC inventory was achieved by increasing double apheresis collections and production of double doses using pools of two single apheresis units. Discard rates decreased from 6% to 3% after PR implementation and further decreased to 1.2% after seven-day storage extension for PR-PCs. The blood utilization remained stable, with no increase in component utilization. A significant decrease in adverse transfusion events was observed after the PR implementation. (4) Conclusion: Our experience demonstrates the feasibility for Brazilian blood centers to achieve a 100% PR-PC inventory. All patients at our hospital received PR-PC and showed no increase in blood component utilization and decreased rates of adverse transfusion reactions.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/pathogens10111499
- https://www.mdpi.com/2076-0817/10/11/1499/pdf?version=1637204224
- OA Status
- gold
- Cited By
- 6
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3212442082
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3212442082Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/pathogens10111499Digital Object Identifier
- Title
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The 4-Year Experience with Implementation and Routine Use of Pathogen Reduction in a Brazilian HospitalWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-11-18Full publication date if available
- Authors
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Roberta Fachini, Rita Fontão‐Wendel, Ruth Achkar, Patrícia Scuracchio, Mayra Brito, Marcelo Amaral, Silvano WendelList of authors in order
- Landing page
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https://doi.org/10.3390/pathogens10111499Publisher landing page
- PDF URL
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https://www.mdpi.com/2076-0817/10/11/1499/pdf?version=1637204224Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2076-0817/10/11/1499/pdf?version=1637204224Direct OA link when available
- Concepts
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Apheresis, Adverse effect, Medicine, Platelet, Blood bank, Population, Blood transfusion, Emergency medicine, Plateletpheresis, Internal medicine, Environmental healthTop concepts (fields/topics) attached by OpenAlex
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6Total citation count in OpenAlex
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2024: 2, 2023: 1, 2022: 3Per-year citation counts (last 5 years)
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48Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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