The AlphaFold Database Ages Article Swipe

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Ifigenia Tsitsa , Anja Conev , Alessia David , Suhail A. Islam , Michael J.E. Sternberg ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1101/2025.06.22.660930

The AlphaFold database provides 200M protein structures predicted by AlphaFold2 and released in 2022 from sequences in UniProt in April 2021. However, of the 20,504 full-length human structures in the AlphaFold database, 631 entries conflict with UniProt (version 2025_03 i.e. release 3 of 2025 published Jun 18, 2025); and there is a similar discrepancy for other species. This highlights how bioinformatics resources, as exemplified by the AlphaFold database can rapidly age. Time flies in bioinformatics.

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1101/2025.06.22.660930
PDF: https://www.biorxiv.org/content/biorxiv/early/2025/06/25/2025.06.22.660930.full.pdf
OA Status: green
Cited By: 1
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DOI: https://doi.org/10.1101/2025.06.22.660930

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Title: The AlphaFold Database Ages

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Type: preprint

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Language: en

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Publication year: 2025

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Publication date: 2025-06-25

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Authors: Ifigenia Tsitsa, Anja Conev, Alessia David, Suhail A. Islam, Michael J.E. Sternberg

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Landing page: https://doi.org/10.1101/2025.06.22.660930

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Concepts: Database, Computer science

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Cited by: 1

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