The Androgen Metabolome of Preterm Infants Reflects Fetal Adrenal Gland Involution Article Swipe
Christa E. Flück
,
Tanja Kuiri‐Hänninen
,
Sanna Silvennoinen
,
Ulla Sankilampi
,
Michael Groessl
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1210/clinem/dgac482
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1210/clinem/dgac482
Context The human adrenal cortex changes with fetal-neonatal transition from the fetal to the adult organ, accompanied by changes in the steroid metabolome. Objective As it is unclear how the observed developmental changes differ between preterm and full-term neonates, we investigated whether the involution of the fetal adrenals is following a fixed time course related to postmenstrual age or whether it is triggered by birth. Furthermore, the fetal and postnatal androgen metabolome of preterm infants was characterized in comparison to term babies. Methods This was a prospective, longitudinal, 2-center study collecting spot urines of preterm and term infants during the first 12 to 18 months of life. Steroid metabolites were measured from spot urines by gas chromatography–mass spectrometry. Data relating were modeled according to established pre- and postnatal pathways. Results Fetal adrenal involution occurs around term-equivalent age in preterm infants and is not triggered by premature birth. Testosterone levels are higher in preterm infants at birth and decline slower until term compared to full-term babies. Dihydrotestosterone levels and the activity of the classic androgen biosynthesis pathway are lower in premature infants as is 5α-reductase activity. No difference was found in the activity of the alternate backdoor pathway for androgen synthesis. Conclusion Human adrenal involution follows a strict timing that is not affected by premature birth. By contrast, prematurity is associated with an altered androgen metabolome after birth. Whether this reflects altered androgen biosynthesis in utero remains to be investigated.
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Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1210/clinem/dgac482
- https://academic.oup.com/jcem/article-pdf/107/11/3111/47201224/dgac482.pdf
- OA Status
- bronze
- Cited By
- 11
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4292664345
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4292664345Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1210/clinem/dgac482Digital Object Identifier
- Title
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The Androgen Metabolome of Preterm Infants Reflects Fetal Adrenal Gland InvolutionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-08-22Full publication date if available
- Authors
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Christa E. Flück, Tanja Kuiri‐Hänninen, Sanna Silvennoinen, Ulla Sankilampi, Michael GroesslList of authors in order
- Landing page
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https://doi.org/10.1210/clinem/dgac482Publisher landing page
- PDF URL
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https://academic.oup.com/jcem/article-pdf/107/11/3111/47201224/dgac482.pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
bronzeOpen access status per OpenAlex
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https://academic.oup.com/jcem/article-pdf/107/11/3111/47201224/dgac482.pdfDirect OA link when available
- Concepts
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Metabolome, Involution (esoterism), Androgen, Fetus, Endocrinology, Internal medicine, Physiology, Biology, Medicine, Pregnancy, Hormone, Metabolite, Neuroscience, Genetics, ConsciousnessTop concepts (fields/topics) attached by OpenAlex
- Cited by
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11Total citation count in OpenAlex
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2025: 6, 2024: 3, 2023: 1, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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50Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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