The Androgen Regulation of Matrix Metalloproteases in Prostate Cancer and Its Related Tumor Microenvironment Article Swipe
Carmela Sorrentino
,
Rosa D’Angiolo
,
Giulia Gentile
,
Pia Giovannelli
,
Bruno Perillo
,
Antimo Migliaccio
,
Gabriella Castoria
,
Marzia Di Donato
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/endocrines4020027
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/endocrines4020027
Prostate cancer represents the most common type of cancer among males and the second leading cause of cancer death in men in Western society. In most cases (~70%), PC has a slow and symptom-free growth, whereas it is more aggressive in the remaining patients. Current PC therapies prevalently target the proliferative function of the androgen receptor and may only be effective within short periods, beyond which the disease will progress to metastatic and castration-resistant phenotype. Preclinical and clinical studies are aimed at investigating the molecular basis for prostate cancer spreading. Although considerable efforts have been made to dissect the programs that foster prostate cancer spreading, few biomarkers predictive of metastatic phenotype have yet been identified and few therapeutic options are available for treatment of the metastatic disease. In the present paper, we will discuss innovative aspects of prostate cancer biology, which impinge on the role of cancer-associated fibroblasts and the released matrix metalloproteinases in the disease progression. Investigating these aspects might allow the discovery of clinically actionable biomarkers to target in the advanced stages of prostate cancer.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/endocrines4020027
- https://www.mdpi.com/2673-396X/4/2/27/pdf?version=1683698464
- OA Status
- gold
- Cited By
- 8
- References
- 140
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4382238658
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4382238658Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/endocrines4020027Digital Object Identifier
- Title
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The Androgen Regulation of Matrix Metalloproteases in Prostate Cancer and Its Related Tumor MicroenvironmentWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-05-09Full publication date if available
- Authors
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Carmela Sorrentino, Rosa D’Angiolo, Giulia Gentile, Pia Giovannelli, Bruno Perillo, Antimo Migliaccio, Gabriella Castoria, Marzia Di DonatoList of authors in order
- Landing page
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https://doi.org/10.3390/endocrines4020027Publisher landing page
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https://www.mdpi.com/2673-396X/4/2/27/pdf?version=1683698464Direct link to full text PDF
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2673-396X/4/2/27/pdf?version=1683698464Direct OA link when available
- Concepts
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Prostate cancer, Disease, Cancer, Androgen receptor, Medicine, Cancer research, Tumor microenvironment, Prostate, Oncology, Phenotype, Metastasis, Internal medicine, Bioinformatics, Biology, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
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2025: 7, 2024: 1Per-year citation counts (last 5 years)
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140Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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