The Anti-Inflammatory Effects of Angiogenin in an Endotoxin Induced Uveitis in Rats Article Swipe
Jihae Park
,
Jee Taek Kim
,
Soojin Lee
,
Jae Chan Kim
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/ijms21020413
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/ijms21020413
Angiogenin (ANG) is involved in the innate immune system and inflammatory disease. The aim of this study is to evaluate the anti-inflammatory effects of ANG in an endotoxin induced uveitis (EIU) rat model and the pathways involved. EIU rats were treated with balanced salt solution (BSS), a non-functional mutant ANG (mANG), or wild-type ANG (ANG). The integrity of the blood-aqueous barrier was evaluated by the infiltrating cell and protein concentrations in aqueous humor. Histopathology, Western blot, and real-time qRT-PCR of aqueous humor and ocular tissue were performed to analyze inflammatory cytokines and transcription factors. EIU treated with ANG had decreased inflammatory cells and protein concentrations in the anterior chamber. Compared to BSS and mANG, ANG treatment showed reduced expression of IL-1β, IL-8, TNF-α, and Myd88, while the expression of IL-4 and IL-10 was increased. Western blot of ANG treatment showed decreased expression of IL-6, inducible nitric oxide synthase (iNOS), IL-1β, TNF-α, and phosphorylated NF-κB and increased expression of IL-10. In conclusion, ANG seems to reduce effectively immune mediated inflammation in the EIU rat model by reducing the expression of proinflammatory cytokines, while increasing the expression of anti-inflammatory cytokines through pathways related to NF-κB. Therefore, ANG shows potential for effectively suppressing immune-inflammatory responses in vivo.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms21020413
- https://www.mdpi.com/1422-0067/21/2/413/pdf?version=1578560509
- OA Status
- gold
- Cited By
- 30
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2999465666
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Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2999465666Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms21020413Digital Object Identifier
- Title
-
The Anti-Inflammatory Effects of Angiogenin in an Endotoxin Induced Uveitis in RatsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-09Full publication date if available
- Authors
-
Jihae Park, Jee Taek Kim, Soojin Lee, Jae Chan KimList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms21020413Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/21/2/413/pdf?version=1578560509Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/21/2/413/pdf?version=1578560509Direct OA link when available
- Concepts
-
Angiogenin, Proinflammatory cytokine, Western blot, Inflammation, Nitric oxide synthase, Uveitis, Tumor necrosis factor alpha, Chemistry, Nitric oxide, Immune system, Interleukin, Lipopolysaccharide, Endocrinology, Immunology, Internal medicine, Biology, Medicine, Cytokine, Angiogenesis, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
30Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 5, 2023: 6, 2022: 5, 2021: 7Per-year citation counts (last 5 years)
- References (count)
-
69Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.TNF-α, | 122, 150 |
| abstract_inverted_index.Western | 74, 134 |
| abstract_inverted_index.analyze | 88 |
| abstract_inverted_index.aqueous | 71, 80 |
| abstract_inverted_index.barrier | 60 |
| abstract_inverted_index.effects | 22 |
| abstract_inverted_index.induced | 28 |
| abstract_inverted_index.protein | 68, 103 |
| abstract_inverted_index.qRT-PCR | 78 |
| abstract_inverted_index.reduced | 117 |
| abstract_inverted_index.related | 190 |
| abstract_inverted_index.through | 188 |
| abstract_inverted_index.treated | 40, 95 |
| abstract_inverted_index.uveitis | 29 |
| abstract_inverted_index.Compared | 109 |
| abstract_inverted_index.anterior | 107 |
| abstract_inverted_index.balanced | 42 |
| abstract_inverted_index.chamber. | 108 |
| abstract_inverted_index.disease. | 11 |
| abstract_inverted_index.evaluate | 19 |
| abstract_inverted_index.factors. | 93 |
| abstract_inverted_index.involved | 3 |
| abstract_inverted_index.mediated | 167 |
| abstract_inverted_index.pathways | 35, 189 |
| abstract_inverted_index.reducing | 175 |
| abstract_inverted_index.solution | 44 |
| abstract_inverted_index.synthase | 147 |
| abstract_inverted_index.cytokines | 90, 187 |
| abstract_inverted_index.decreased | 99, 140 |
| abstract_inverted_index.endotoxin | 27 |
| abstract_inverted_index.evaluated | 62 |
| abstract_inverted_index.increased | 155 |
| abstract_inverted_index.inducible | 144 |
| abstract_inverted_index.integrity | 56 |
| abstract_inverted_index.involved. | 36 |
| abstract_inverted_index.performed | 86 |
| abstract_inverted_index.potential | 196 |
| abstract_inverted_index.real-time | 77 |
| abstract_inverted_index.responses | 201 |
| abstract_inverted_index.treatment | 115, 138 |
| abstract_inverted_index.wild-type | 52 |
| abstract_inverted_index.Angiogenin | 0 |
| abstract_inverted_index.Therefore, | 193 |
| abstract_inverted_index.cytokines, | 180 |
| abstract_inverted_index.expression | 118, 127, 141, 156, 177, 184 |
| abstract_inverted_index.increased. | 133 |
| abstract_inverted_index.increasing | 182 |
| abstract_inverted_index.conclusion, | 160 |
| abstract_inverted_index.effectively | 165, 198 |
| abstract_inverted_index.suppressing | 199 |
| abstract_inverted_index.infiltrating | 65 |
| abstract_inverted_index.inflammation | 168 |
| abstract_inverted_index.inflammatory | 10, 89, 100 |
| abstract_inverted_index.blood-aqueous | 59 |
| abstract_inverted_index.transcription | 92 |
| abstract_inverted_index.concentrations | 69, 104 |
| abstract_inverted_index.non-functional | 47 |
| abstract_inverted_index.phosphorylated | 152 |
| abstract_inverted_index.Histopathology, | 73 |
| abstract_inverted_index.proinflammatory | 179 |
| abstract_inverted_index.anti-inflammatory | 21, 186 |
| abstract_inverted_index.immune-inflammatory | 200 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5103263364 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| corresponding_institution_ids | https://openalex.org/I4210133638, https://openalex.org/I4210153376 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6000000238418579 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.9239751 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |