The antihemostatic profile of vitamin C: Mechanisms that underlie the technical application of a physiological molecule Article Swipe
P.C Sathler
,
André Luiz Lourenço
,
Max Saito
,
Ana Paula Mattos Arêas
,
Carlos Rodrigues
,
Lourdes Maria Corrêa Cabral
,
Helena Carla Castro
,
Hye Chung Kang
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.2298/abs150413024s
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.2298/abs150413024s
The potential of antioxidants as tools for lowering the incidence of diseases, including cardiovascular events, is of growing interest. Some antioxidants (e.g. vitamin E and acetyl-salicylic acid) have been described as effective on cardiovascular diseases with mechanisms that differ from other scavenging agents. Currently, vitamin C is used to open occluded long-term central venous catheters, which avoids the process of reinserting a new one and injuring the patient. In this work, we investigated the vitamin C antihemostatic profile by evaluating its effects on the coagulation process. We used different assays, including prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT) and ancrod time tests. We also examined the overall pH disturbance caused by vitamin C at different concentrations and its effect on the thrombin-initiated fibrin polymerization assay. Our results revealed a significant anticoagulant activity of vitamin C at high plasma concentrations (surpassing the normal 100 ?mol/L ratio) in a cell-independent mechanism. Our results suggest that vitamin C may affect blood coagulation by a direct impairment of fibrin assembly and further formation of a cohesive clot microstructure. This study supports the literature that points to the antihemostatic ability of antioxidant agents, and clarifies the mechanism of vitamin C in opening occluded long-term central venous catheters.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2298/abs150413024s
- http://www.doiserbia.nb.rs/ft.aspx?id=0354-46641600024S
- OA Status
- diamond
- Cited By
- 1
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2335190534
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2335190534Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2298/abs150413024sDigital Object Identifier
- Title
-
The antihemostatic profile of vitamin C: Mechanisms that underlie the technical application of a physiological moleculeWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-01-01Full publication date if available
- Authors
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P.C Sathler, André Luiz Lourenço, Max Saito, Ana Paula Mattos Arêas, Carlos Rodrigues, Lourdes Maria Corrêa Cabral, Helena Carla Castro, Hye Chung KangList of authors in order
- Landing page
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https://doi.org/10.2298/abs150413024sPublisher landing page
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https://www.doiserbia.nb.rs/ft.aspx?id=0354-46641600024SDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
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https://www.doiserbia.nb.rs/ft.aspx?id=0354-46641600024SDirect OA link when available
- Concepts
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Partial thromboplastin time, Fibrin, Prothrombin time, Coagulation, Antioxidant, Salicylic acid, Vitamin, Chemistry, Thrombin, Vitamin E, Vitamin C, Thromboplastin, Anticoagulant, Biochemistry, Pharmacology, Internal medicine, Medicine, Platelet, ImmunologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2020: 1Per-year citation counts (last 5 years)
- References (count)
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29Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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