The association between asthma and atrial fibrillation: systematic review and meta-analysis Article Swipe
Beatriz Nogueira-Garcia
,
Mariana Alves
,
Fausto J. Pinto
,
Daniel Caldeira
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-023-50466-w
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-023-50466-w
Respiratory disease and atrial fibrillation (AF) frequent coexist, but the risk of AF among asthma patients is less characterized. Growing evidence suggest that AF shares with asthma a systemic inflammation background and asthma treatments, such as beta agonists, have been associated with increased risk of cardiac arrhythmias. The aim of this systematic review was to assess the risk of AF in patients with asthma in observational studies. We search for longitudinal studies reporting AF outcome in asthma and control patients through MEDLINE, Cochrane Central Register of Controlled Trials and EMBASE. Pooled estimates of odds ratios (ORs) and 95% confidence intervals (CIs) were derived by random effects meta-analysis. Heterogeneity was assessed using the I2 test. The risk of bias of individual studies was evaluated using the ROBINS-E tool. The study protocol was registered at PROSPERO: CRD42020215707. Seven cohort/nested case–control studies with 1 405 508 individuals were included. The mean follow-up time was 9 years, ranging from 1 to 15 years. Asthma was associated with a higher risk of AF (OR 1.15. 95% CI 1.01–1.29). High heterogeneity (I 2 = 81%) and overall “serious” risk of bias, lead to a very low confidence in in this result. Asthma was associated with an increased risk of AF. However, the high risk of bias and high heterogeneity reduces the robustness of these results, calling for further high-quality data.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-023-50466-w
- https://www.nature.com/articles/s41598-023-50466-w.pdf
- OA Status
- gold
- Cited By
- 3
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391257078
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391257078Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41598-023-50466-wDigital Object Identifier
- Title
-
The association between asthma and atrial fibrillation: systematic review and meta-analysisWork title
- Type
-
reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-26Full publication date if available
- Authors
-
Beatriz Nogueira-Garcia, Mariana Alves, Fausto J. Pinto, Daniel CaldeiraList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-023-50466-wPublisher landing page
- PDF URL
-
https://www.nature.com/articles/s41598-023-50466-w.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.nature.com/articles/s41598-023-50466-w.pdfDirect OA link when available
- Concepts
-
Medicine, Asthma, Meta-analysis, Odds ratio, Atrial fibrillation, Internal medicine, Confidence interval, Study heterogeneity, Observational study, Publication bias, Relative risk, Cohort studyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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38Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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