The association between high atherogenic index of plasma and impaired lung function: a population-based study Article Swipe
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· 2025
· Open Access
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· DOI: https://doi.org/10.3389/fmed.2025.1589605
· OA: W4412140167
Objective Although AIP is a recognized cardiovascular risk marker, its association with pulmonary function and sex-specific differences remains unclear. This study investigated whether elevated AIP is independently associated with reduced lung function and examined potential sex-specific patterns. Methods Data from 4,565 participants in the NHANES 2007–2012 dataset were analyzed using a cross-sectional design. AIP served as the exposure variable, with five lung function metrics (including FEV 1 , FVC, and FEV 1 /FVC ratio) as outcomes. Weighted multiple linear regression, threshold effect analysis, subgroup comparisons, and XGBoost modeling were performed to assess associations. Results Multivariable regression showed a significant negative association between AIP and FEV 1 (β = −121.3 mL/unit, p < 0.001) and FVC (β = −147.1 mL/unit, p < 0.001), with no significant link to FEV 1 /FVC ratio. Subgroup analysis revealed a U-shaped non-linear association in females, with inflection points at AIP values of 0.77 (FEV 1 ) and 0.78 (FVC), beyond which declines in lung function plateaued. Males exhibited a consistent negative correlation across all AIP levels. Conclusion Elevated AIP is independently associated with reduced lung function, particularly non-linear effects in females. These findings support AIP as a potential adjunct marker for pulmonary function assessment in clinical practice.
