The association between human papillomavirus type 16 seropositivity and oropharyngeal cancer among men living with HIV Article Swipe
Amy Duff
,
Anna Junkins
,
Li Chen
,
Kyle Mannion
,
Michael C. Topf
,
Tim Waterboer
,
Birgitta E. Michels
,
Julia Butt
,
Beverly Woodward
,
Morgan C. Lima
,
Husamettin Erdem
,
Michael Leonard
,
Megan Turner
,
Staci L. Sudenga
,
Krystle A. Lang Kuhs
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/cncr.70167
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/cncr.70167
Background There are no methods for the early detection of human papillomavirus–driven oropharyngeal squamous cell carcinoma (HPV+OPSCC); however, HPV16 E6 seropositivity has been identified as a promising screening marker. Although people living with HIV have a higher risk of developing HPV+OPSCC, few studies have evaluated the association between HPV16 antibodies and HPV+OPSCC. Methods The association between HPV16 seropositivity (L1, E1, E2, E4, E6, and E7) and OPSCC was assessed among 2331 men living with HIV (MLWH) aged ≥40 years who had blood specimens banked within the Tennessee Center for AIDS Research biorepository between 2001 and 2019; some samples were collected before OPSCC diagnosis, and others after. The association between HPV16 seropositivity and OPSCC was analyzed via univariable logistic regression. Results One hundred and thirty‐five HPV16 E6 seropositive cases and 11 OPSCC cases were identified. HPV16 E6 seropositivity was associated with a 14‐fold higher odds of OPSCC (odds ratio [OR], 14.04; 95% CI, 4.23–46.61; p < .001); five of the 11 OPSCC cases were HPV16 E6 seropositive (sensitivity, 45%; 95% CI, 17%–77%) compared to 6% of controls (specificity, 94%; 95% CI, 93%–95%). Seroreactivity against HPV16 E1 (OR, 7.14; 95% CI, 1.52–33.67; p = .013), HPV16 E2 (OR, 16.43; 95% CI, 4.94–54.65; p < .001), and HPV16 E7 (OR, 13.84; 95% CI, 3.99–48.11; p < .001) was also significantly associated with OPSCC. HPV16 E6 antibodies were detectable up to 9 years before and 19 years after OPSCC diagnosis. Conclusions Among MLWH, HPV16 E6 antibodies are strongly associated with OPSCC, yet point estimates of the sensitivity and specificity of HPV16 E6 antibodies for OPSCC were lower compared to studies in populations without HIV.
Related Topics
Concepts
No concepts available.
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/cncr.70167
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.70167
- OA Status
- bronze
- References
- 22
- OpenAlex ID
- https://openalex.org/W4415982637
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4415982637Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/cncr.70167Digital Object Identifier
- Title
-
The association between human papillomavirus type 16 seropositivity and oropharyngeal cancer among men living with HIVWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-06Full publication date if available
- Authors
-
Amy Duff, Anna Junkins, Li Chen, Kyle Mannion, Michael C. Topf, Tim Waterboer, Birgitta E. Michels, Julia Butt, Beverly Woodward, Morgan C. Lima, Husamettin Erdem, Michael Leonard, Megan Turner, Staci L. Sudenga, Krystle A. Lang KuhsList of authors in order
- Landing page
-
https://doi.org/10.1002/cncr.70167Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.70167Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.70167Direct OA link when available
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
22Number of works referenced by this work
Full payload
| id | https://openalex.org/W4415982637 |
|---|---|
| doi | https://doi.org/10.1002/cncr.70167 |
| ids.doi | https://doi.org/10.1002/cncr.70167 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/41199491 |
| ids.openalex | https://openalex.org/W4415982637 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D008297 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Male |
| mesh[2].qualifier_ui | Q000821 |
| mesh[2].descriptor_ui | D009959 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | virology |
| mesh[2].descriptor_name | Oropharyngeal Neoplasms |
| mesh[3].qualifier_ui | Q000097 |
| mesh[3].descriptor_ui | D009959 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | blood |
| mesh[3].descriptor_name | Oropharyngeal Neoplasms |
| mesh[4].qualifier_ui | Q000453 |
| mesh[4].descriptor_ui | D009959 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | epidemiology |
| mesh[4].descriptor_name | Oropharyngeal Neoplasms |
| mesh[5].qualifier_ui | Q000175 |
| mesh[5].descriptor_ui | D009959 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | diagnosis |
| mesh[5].descriptor_name | Oropharyngeal Neoplasms |
| mesh[6].qualifier_ui | Q000276 |
| mesh[6].descriptor_ui | D009959 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | immunology |
| mesh[6].descriptor_name | Oropharyngeal Neoplasms |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D008875 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Middle Aged |
| mesh[8].qualifier_ui | Q000276 |
| mesh[8].descriptor_ui | D052162 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | immunology |
| mesh[8].descriptor_name | Human papillomavirus 16 |
| mesh[9].qualifier_ui | Q000302 |
| mesh[9].descriptor_ui | D052162 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | isolation & purification |
| mesh[9].descriptor_name | Human papillomavirus 16 |
| mesh[10].qualifier_ui | Q000821 |
| mesh[10].descriptor_ui | D030361 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | virology |
| mesh[10].descriptor_name | Papillomavirus Infections |
| mesh[11].qualifier_ui | Q000150 |
| mesh[11].descriptor_ui | D030361 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | complications |
| mesh[11].descriptor_name | Papillomavirus Infections |
| mesh[12].qualifier_ui | Q000276 |
| mesh[12].descriptor_ui | D030361 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | immunology |
| mesh[12].descriptor_name | Papillomavirus Infections |
| mesh[13].qualifier_ui | Q000453 |
| mesh[13].descriptor_ui | D030361 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | epidemiology |
| mesh[13].descriptor_name | Papillomavirus Infections |
| mesh[14].qualifier_ui | Q000097 |
| mesh[14].descriptor_ui | D030361 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | blood |
| mesh[14].descriptor_name | Papillomavirus Infections |
| mesh[15].qualifier_ui | Q000150 |
| mesh[15].descriptor_ui | D015658 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | complications |
| mesh[15].descriptor_name | HIV Infections |
| mesh[16].qualifier_ui | Q000821 |
| mesh[16].descriptor_ui | D015658 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | virology |
| mesh[16].descriptor_name | HIV Infections |
| mesh[17].qualifier_ui | Q000276 |
| mesh[17].descriptor_ui | D015658 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | immunology |
| mesh[17].descriptor_name | HIV Infections |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D000328 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Adult |
| mesh[19].qualifier_ui | Q000276 |
| mesh[19].descriptor_ui | D009856 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | immunology |
| mesh[19].descriptor_name | Oncogene Proteins, Viral |
| mesh[20].qualifier_ui | Q000097 |
| mesh[20].descriptor_ui | D000914 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | blood |
| mesh[20].descriptor_name | Antibodies, Viral |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D000368 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Aged |
| mesh[22].qualifier_ui | Q000276 |
| mesh[22].descriptor_ui | D012097 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | immunology |
| mesh[22].descriptor_name | Repressor Proteins |
| type | article |
| title | The association between human papillomavirus type 16 seropositivity and oropharyngeal cancer among men living with HIV |
| biblio.issue | 22 |
| biblio.volume | 131 |
| biblio.last_page | e70167 |
| biblio.first_page | e70167 |
| is_xpac | False |
| apc_list.value | 4740 |
| apc_list.currency | USD |
| apc_list.value_usd | 4740 |
| apc_paid | |
| language | en |
| locations[0].id | doi:10.1002/cncr.70167 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S126033908 |
| locations[0].source.issn | 0008-543X, 1045-7410, 1097-0142 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0008-543X |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Cancer |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].license | |
| locations[0].pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.70167 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cancer |
| locations[0].landing_page_url | https://doi.org/10.1002/cncr.70167 |
| locations[1].id | pmid:41199491 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cancer |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/41199491 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5051793836 |
| authorships[0].author.orcid | https://orcid.org/0009-0004-6143-9823 |
| authorships[0].author.display_name | Amy Duff |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I143302722 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Epidemiology and Environmental Health, College of Public Health, University of Kentucky, Lexington, Kentucky, USA |
| authorships[0].institutions[0].id | https://openalex.org/I143302722 |
| authorships[0].institutions[0].ror | https://ror.org/02k3smh20 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I143302722 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | University of Kentucky |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Ashley J. Duff |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Epidemiology and Environmental Health, College of Public Health, University of Kentucky, Lexington, Kentucky, USA |
| authorships[1].author.id | https://openalex.org/A5069271993 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-6094-1089 |
| authorships[1].author.display_name | Anna Junkins |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I901861585 |
| authorships[1].affiliations[0].raw_affiliation_string | Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA |
| authorships[1].institutions[0].id | https://openalex.org/I901861585 |
| authorships[1].institutions[0].ror | https://ror.org/05dq2gs74 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210162197, https://openalex.org/I901861585 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Vanderbilt University Medical Center |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Anna Junkins |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA |
| authorships[2].author.id | https://openalex.org/A5100379200 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-9971-9653 |
| authorships[2].author.display_name | Li Chen |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I143302722, https://openalex.org/I2802239656 |
| authorships[2].affiliations[0].raw_affiliation_string | Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA |
| authorships[2].institutions[0].id | https://openalex.org/I2802239656 |
| authorships[2].institutions[0].ror | https://ror.org/01dhvva97 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I1285210727, https://openalex.org/I2802239656 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Markey Cancer Center |
| authorships[2].institutions[1].id | https://openalex.org/I143302722 |
| authorships[2].institutions[1].ror | https://ror.org/02k3smh20 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I143302722 |
| authorships[2].institutions[1].country_code | US |
| authorships[2].institutions[1].display_name | University of Kentucky |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Li Chen |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA |
| authorships[3].author.id | https://openalex.org/A5074483897 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-9391-1791 |
| authorships[3].author.display_name | Kyle Mannion |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I901861585 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Otolaryngology–Head and Neck Surgery Vanderbilt University Medical Center Nashville Tennessee USA |
| authorships[3].institutions[0].id | https://openalex.org/I901861585 |
| authorships[3].institutions[0].ror | https://ror.org/05dq2gs74 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210162197, https://openalex.org/I901861585 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Vanderbilt University Medical Center |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Kyle Mannion |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Otolaryngology–Head and Neck Surgery Vanderbilt University Medical Center Nashville Tennessee USA |
| authorships[4].author.id | https://openalex.org/A5030518044 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1022-4417 |
| authorships[4].author.display_name | Michael C. Topf |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I901861585 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Otolaryngology–Head and Neck Surgery Vanderbilt University Medical Center Nashville Tennessee USA |
| authorships[4].institutions[0].id | https://openalex.org/I901861585 |
| authorships[4].institutions[0].ror | https://ror.org/05dq2gs74 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210162197, https://openalex.org/I901861585 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Vanderbilt University Medical Center |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Michael C. Topf |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Otolaryngology–Head and Neck Surgery Vanderbilt University Medical Center Nashville Tennessee USA |
| authorships[5].author.id | https://openalex.org/A5080937699 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-0616-6963 |
| authorships[5].author.display_name | Tim Waterboer |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I17937529, https://openalex.org/I223822909 |
| authorships[5].affiliations[0].raw_affiliation_string | Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany |
| authorships[5].institutions[0].id | https://openalex.org/I17937529 |
| authorships[5].institutions[0].ror | https://ror.org/04cdgtt98 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I17937529 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | German Cancer Research Center |
| authorships[5].institutions[1].id | https://openalex.org/I223822909 |
| authorships[5].institutions[1].ror | https://ror.org/038t36y30 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I223822909 |
| authorships[5].institutions[1].country_code | DE |
| authorships[5].institutions[1].display_name | Heidelberg University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Tim Waterboer |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany |
| authorships[6].author.id | https://openalex.org/A5078807718 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-9948-4567 |
| authorships[6].author.display_name | Birgitta E. Michels |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I17937529, https://openalex.org/I223822909 |
| authorships[6].affiliations[0].raw_affiliation_string | Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany |
| authorships[6].institutions[0].id | https://openalex.org/I17937529 |
| authorships[6].institutions[0].ror | https://ror.org/04cdgtt98 |
| authorships[6].institutions[0].type | facility |
| authorships[6].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I17937529 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | German Cancer Research Center |
| authorships[6].institutions[1].id | https://openalex.org/I223822909 |
| authorships[6].institutions[1].ror | https://ror.org/038t36y30 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I223822909 |
| authorships[6].institutions[1].country_code | DE |
| authorships[6].institutions[1].display_name | Heidelberg University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Birgitta E. Michels |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany |
| authorships[7].author.id | https://openalex.org/A5048935486 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-7738-8611 |
| authorships[7].author.display_name | Julia Butt |
| authorships[7].countries | DE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I17937529, https://openalex.org/I223822909 |
| authorships[7].affiliations[0].raw_affiliation_string | Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany |
| authorships[7].institutions[0].id | https://openalex.org/I17937529 |
| authorships[7].institutions[0].ror | https://ror.org/04cdgtt98 |
| authorships[7].institutions[0].type | facility |
| authorships[7].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I17937529 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | German Cancer Research Center |
| authorships[7].institutions[1].id | https://openalex.org/I223822909 |
| authorships[7].institutions[1].ror | https://ror.org/038t36y30 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I223822909 |
| authorships[7].institutions[1].country_code | DE |
| authorships[7].institutions[1].display_name | Heidelberg University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Julia Butt |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany |
| authorships[8].author.id | https://openalex.org/A5087160140 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-5424-6960 |
| authorships[8].author.display_name | Beverly Woodward |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I901861585 |
| authorships[8].affiliations[0].raw_affiliation_string | Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA |
| authorships[8].affiliations[1].raw_affiliation_string | Tennessee Center for AIDS Research, Nashville, Tennessee, USA |
| authorships[8].institutions[0].id | https://openalex.org/I901861585 |
| authorships[8].institutions[0].ror | https://ror.org/05dq2gs74 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210162197, https://openalex.org/I901861585 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Vanderbilt University Medical Center |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Beverly O. Woodward |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA, Tennessee Center for AIDS Research, Nashville, Tennessee, USA |
| authorships[9].author.id | https://openalex.org/A5112610475 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-0307-8965 |
| authorships[9].author.display_name | Morgan C. Lima |
| authorships[9].countries | US |
| authorships[9].affiliations[0].raw_affiliation_string | Tennessee Center for AIDS Research, Nashville, Tennessee, USA |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I901861585 |
| authorships[9].affiliations[1].raw_affiliation_string | Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA |
| authorships[9].institutions[0].id | https://openalex.org/I901861585 |
| authorships[9].institutions[0].ror | https://ror.org/05dq2gs74 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210162197, https://openalex.org/I901861585 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | Vanderbilt University Medical Center |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Morgan C. Lima |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA, Tennessee Center for AIDS Research, Nashville, Tennessee, USA |
| authorships[10].author.id | https://openalex.org/A5016780373 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Husamettin Erdem |
| authorships[10].countries | US |
| authorships[10].affiliations[0].raw_affiliation_string | Tennessee Center for AIDS Research, Nashville, Tennessee, USA |
| authorships[10].affiliations[1].institution_ids | https://openalex.org/I901861585 |
| authorships[10].affiliations[1].raw_affiliation_string | Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA |
| authorships[10].institutions[0].id | https://openalex.org/I901861585 |
| authorships[10].institutions[0].ror | https://ror.org/05dq2gs74 |
| authorships[10].institutions[0].type | healthcare |
| authorships[10].institutions[0].lineage | https://openalex.org/I4210162197, https://openalex.org/I901861585 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | Vanderbilt University Medical Center |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Husamettin Erdem |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA, Tennessee Center for AIDS Research, Nashville, Tennessee, USA |
| authorships[11].author.id | https://openalex.org/A5062434935 |
| authorships[11].author.orcid | |
| authorships[11].author.display_name | Michael Leonard |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I901861585 |
| authorships[11].affiliations[0].raw_affiliation_string | Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA |
| authorships[11].affiliations[1].raw_affiliation_string | Tennessee Center for AIDS Research, Nashville, Tennessee, USA |
| authorships[11].institutions[0].id | https://openalex.org/I901861585 |
| authorships[11].institutions[0].ror | https://ror.org/05dq2gs74 |
| authorships[11].institutions[0].type | healthcare |
| authorships[11].institutions[0].lineage | https://openalex.org/I4210162197, https://openalex.org/I901861585 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | Vanderbilt University Medical Center |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Michael A. Leonard |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA, Tennessee Center for AIDS Research, Nashville, Tennessee, USA |
| authorships[12].author.id | https://openalex.org/A5001438803 |
| authorships[12].author.orcid | https://orcid.org/0000-0001-5180-2773 |
| authorships[12].author.display_name | Megan Turner |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I901861585 |
| authorships[12].affiliations[0].raw_affiliation_string | Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA |
| authorships[12].affiliations[1].raw_affiliation_string | Tennessee Center for AIDS Research, Nashville, Tennessee, USA |
| authorships[12].institutions[0].id | https://openalex.org/I901861585 |
| authorships[12].institutions[0].ror | https://ror.org/05dq2gs74 |
| authorships[12].institutions[0].type | healthcare |
| authorships[12].institutions[0].lineage | https://openalex.org/I4210162197, https://openalex.org/I901861585 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | Vanderbilt University Medical Center |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Megan M. Turner |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA, Tennessee Center for AIDS Research, Nashville, Tennessee, USA |
| authorships[13].author.id | https://openalex.org/A5016582839 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-7305-8738 |
| authorships[13].author.display_name | Staci L. Sudenga |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I901861585 |
| authorships[13].affiliations[0].raw_affiliation_string | Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA |
| authorships[13].institutions[0].id | https://openalex.org/I901861585 |
| authorships[13].institutions[0].ror | https://ror.org/05dq2gs74 |
| authorships[13].institutions[0].type | healthcare |
| authorships[13].institutions[0].lineage | https://openalex.org/I4210162197, https://openalex.org/I901861585 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | Vanderbilt University Medical Center |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Staci L. Sudenga |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA |
| authorships[14].author.id | https://openalex.org/A5040450337 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-1351-3927 |
| authorships[14].author.display_name | Krystle A. Lang Kuhs |
| authorships[14].countries | US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I143302722, https://openalex.org/I2802239656 |
| authorships[14].affiliations[0].raw_affiliation_string | Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA |
| authorships[14].institutions[0].id | https://openalex.org/I2802239656 |
| authorships[14].institutions[0].ror | https://ror.org/01dhvva97 |
| authorships[14].institutions[0].type | healthcare |
| authorships[14].institutions[0].lineage | https://openalex.org/I1285210727, https://openalex.org/I2802239656 |
| authorships[14].institutions[0].country_code | US |
| authorships[14].institutions[0].display_name | Markey Cancer Center |
| authorships[14].institutions[1].id | https://openalex.org/I143302722 |
| authorships[14].institutions[1].ror | https://ror.org/02k3smh20 |
| authorships[14].institutions[1].type | education |
| authorships[14].institutions[1].lineage | https://openalex.org/I143302722 |
| authorships[14].institutions[1].country_code | US |
| authorships[14].institutions[1].display_name | University of Kentucky |
| authorships[14].author_position | last |
| authorships[14].raw_author_name | Krystle A. Lang Kuhs |
| authorships[14].is_corresponding | True |
| authorships[14].raw_affiliation_strings | Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.70167 |
| open_access.oa_status | bronze |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-11-07T00:00:00 |
| display_name | The association between human papillomavirus type 16 seropositivity and oropharyngeal cancer among men living with HIV |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-08T23:21:52.890332 |
| primary_topic | |
| cited_by_count | 0 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1002/cncr.70167 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S126033908 |
| best_oa_location.source.issn | 0008-543X, 1045-7410, 1097-0142 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0008-543X |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Cancer |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.70167 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cancer |
| best_oa_location.landing_page_url | https://doi.org/10.1002/cncr.70167 |
| primary_location.id | doi:10.1002/cncr.70167 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S126033908 |
| primary_location.source.issn | 0008-543X, 1045-7410, 1097-0142 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0008-543X |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Cancer |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.license | |
| primary_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.70167 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cancer |
| primary_location.landing_page_url | https://doi.org/10.1002/cncr.70167 |
| publication_date | 2025-11-06 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2132239791, https://openalex.org/W2143680521, https://openalex.org/W4285729879, https://openalex.org/W2560043256, https://openalex.org/W2598719214, https://openalex.org/W2758800803, https://openalex.org/W2148344434, https://openalex.org/W2951160398, https://openalex.org/W2462361395, https://openalex.org/W4362735812, https://openalex.org/W2560357579, https://openalex.org/W2987709712, https://openalex.org/W4393990419, https://openalex.org/W2069334003, https://openalex.org/W2066771684, https://openalex.org/W2124294874, https://openalex.org/W2121766046, https://openalex.org/W3108559492, https://openalex.org/W2311860340, https://openalex.org/W2595997027, https://openalex.org/W2034455028, https://openalex.org/W4200250347 |
| referenced_works_count | 22 |
| abstract_inverted_index.9 | 228 |
| abstract_inverted_index.= | 192 |
| abstract_inverted_index.a | 26, 36, 141 |
| abstract_inverted_index.p | 154, 191, 201, 212 |
| abstract_inverted_index.11 | 130, 160 |
| abstract_inverted_index.19 | 232 |
| abstract_inverted_index.6% | 174 |
| abstract_inverted_index.E1 | 185 |
| abstract_inverted_index.E2 | 195 |
| abstract_inverted_index.E6 | 20, 126, 136, 165, 222, 241, 258 |
| abstract_inverted_index.E7 | 206 |
| abstract_inverted_index.as | 25 |
| abstract_inverted_index.in | 267 |
| abstract_inverted_index.no | 4 |
| abstract_inverted_index.of | 10, 39, 145, 158, 175, 251, 256 |
| abstract_inverted_index.to | 173, 227, 265 |
| abstract_inverted_index.up | 226 |
| abstract_inverted_index.95% | 151, 169, 179, 188, 198, 209 |
| abstract_inverted_index.CI, | 152, 170, 180, 189, 199, 210 |
| abstract_inverted_index.E1, | 60 |
| abstract_inverted_index.E2, | 61 |
| abstract_inverted_index.E4, | 62 |
| abstract_inverted_index.E6, | 63 |
| abstract_inverted_index.E7) | 65 |
| abstract_inverted_index.HIV | 34, 75 |
| abstract_inverted_index.One | 121 |
| abstract_inverted_index.The | 54, 107 |
| abstract_inverted_index.and | 51, 64, 66, 95, 104, 112, 123, 129, 204, 231, 254 |
| abstract_inverted_index.are | 3, 243 |
| abstract_inverted_index.few | 42 |
| abstract_inverted_index.for | 6, 89, 260 |
| abstract_inverted_index.had | 81 |
| abstract_inverted_index.has | 22 |
| abstract_inverted_index.men | 72 |
| abstract_inverted_index.the | 7, 46, 86, 159, 252 |
| abstract_inverted_index.via | 116 |
| abstract_inverted_index.was | 68, 114, 138, 215 |
| abstract_inverted_index.who | 80 |
| abstract_inverted_index.yet | 248 |
| abstract_inverted_index.< | 155, 202, 213 |
| abstract_inverted_index.(L1, | 59 |
| abstract_inverted_index.(OR, | 186, 196, 207 |
| abstract_inverted_index.2001 | 94 |
| abstract_inverted_index.2331 | 71 |
| abstract_inverted_index.45%; | 168 |
| abstract_inverted_index.94%; | 178 |
| abstract_inverted_index.AIDS | 90 |
| abstract_inverted_index.HIV. | 270 |
| abstract_inverted_index.aged | 77 |
| abstract_inverted_index.also | 216 |
| abstract_inverted_index.been | 23 |
| abstract_inverted_index.cell | 15 |
| abstract_inverted_index.five | 157 |
| abstract_inverted_index.have | 35, 44 |
| abstract_inverted_index.odds | 144 |
| abstract_inverted_index.risk | 38 |
| abstract_inverted_index.some | 97 |
| abstract_inverted_index.were | 99, 133, 163, 224, 262 |
| abstract_inverted_index.with | 33, 74, 140, 219, 246 |
| abstract_inverted_index.(odds | 147 |
| abstract_inverted_index..001) | 214 |
| abstract_inverted_index.2019; | 96 |
| abstract_inverted_index.7.14; | 187 |
| abstract_inverted_index.Among | 238 |
| abstract_inverted_index.HPV16 | 19, 49, 57, 110, 125, 135, 164, 184, 194, 205, 221, 240, 257 |
| abstract_inverted_index.MLWH, | 239 |
| abstract_inverted_index.OPSCC | 67, 102, 113, 131, 146, 161, 235, 261 |
| abstract_inverted_index.There | 2 |
| abstract_inverted_index.[OR], | 149 |
| abstract_inverted_index.after | 234 |
| abstract_inverted_index.among | 70 |
| abstract_inverted_index.blood | 82 |
| abstract_inverted_index.cases | 128, 132, 162 |
| abstract_inverted_index.early | 8 |
| abstract_inverted_index.human | 11 |
| abstract_inverted_index.lower | 263 |
| abstract_inverted_index.point | 249 |
| abstract_inverted_index.ratio | 148 |
| abstract_inverted_index.years | 79, 229, 233 |
| abstract_inverted_index.≥40 | 78 |
| abstract_inverted_index.(MLWH) | 76 |
| abstract_inverted_index..001), | 203 |
| abstract_inverted_index..001); | 156 |
| abstract_inverted_index..013), | 193 |
| abstract_inverted_index.13.84; | 208 |
| abstract_inverted_index.14.04; | 150 |
| abstract_inverted_index.16.43; | 197 |
| abstract_inverted_index.Center | 88 |
| abstract_inverted_index.OPSCC, | 247 |
| abstract_inverted_index.OPSCC. | 220 |
| abstract_inverted_index.after. | 106 |
| abstract_inverted_index.banked | 84 |
| abstract_inverted_index.before | 101, 230 |
| abstract_inverted_index.higher | 37, 143 |
| abstract_inverted_index.living | 32, 73 |
| abstract_inverted_index.others | 105 |
| abstract_inverted_index.people | 31 |
| abstract_inverted_index.within | 85 |
| abstract_inverted_index.Methods | 53 |
| abstract_inverted_index.Results | 120 |
| abstract_inverted_index.against | 183 |
| abstract_inverted_index.between | 48, 56, 93, 109 |
| abstract_inverted_index.hundred | 122 |
| abstract_inverted_index.marker. | 29 |
| abstract_inverted_index.methods | 5 |
| abstract_inverted_index.samples | 98 |
| abstract_inverted_index.studies | 43, 266 |
| abstract_inverted_index.without | 269 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Although | 30 |
| abstract_inverted_index.Research | 91 |
| abstract_inverted_index.analyzed | 115 |
| abstract_inverted_index.assessed | 69 |
| abstract_inverted_index.compared | 172, 264 |
| abstract_inverted_index.controls | 176 |
| abstract_inverted_index.however, | 18 |
| abstract_inverted_index.logistic | 118 |
| abstract_inverted_index.squamous | 14 |
| abstract_inverted_index.strongly | 244 |
| abstract_inverted_index.14‐fold | 142 |
| abstract_inverted_index.Tennessee | 87 |
| abstract_inverted_index.carcinoma | 16 |
| abstract_inverted_index.collected | 100 |
| abstract_inverted_index.detection | 9 |
| abstract_inverted_index.estimates | 250 |
| abstract_inverted_index.evaluated | 45 |
| abstract_inverted_index.promising | 27 |
| abstract_inverted_index.screening | 28 |
| abstract_inverted_index.specimens | 83 |
| abstract_inverted_index.17%–77%) | 171 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.HPV+OPSCC, | 41 |
| abstract_inverted_index.HPV+OPSCC. | 52 |
| abstract_inverted_index.antibodies | 50, 223, 242, 259 |
| abstract_inverted_index.associated | 139, 218, 245 |
| abstract_inverted_index.detectable | 225 |
| abstract_inverted_index.developing | 40 |
| abstract_inverted_index.diagnosis, | 103 |
| abstract_inverted_index.diagnosis. | 236 |
| abstract_inverted_index.identified | 24 |
| abstract_inverted_index.93%–95%). | 181 |
| abstract_inverted_index.Conclusions | 237 |
| abstract_inverted_index.association | 47, 55, 108 |
| abstract_inverted_index.identified. | 134 |
| abstract_inverted_index.populations | 268 |
| abstract_inverted_index.regression. | 119 |
| abstract_inverted_index.sensitivity | 253 |
| abstract_inverted_index.specificity | 255 |
| abstract_inverted_index.univariable | 117 |
| abstract_inverted_index.(HPV+OPSCC); | 17 |
| abstract_inverted_index.seropositive | 127, 166 |
| abstract_inverted_index.(sensitivity, | 167 |
| abstract_inverted_index.(specificity, | 177 |
| abstract_inverted_index.1.52–33.67; | 190 |
| abstract_inverted_index.3.99–48.11; | 211 |
| abstract_inverted_index.4.23–46.61; | 153 |
| abstract_inverted_index.4.94–54.65; | 200 |
| abstract_inverted_index.biorepository | 92 |
| abstract_inverted_index.oropharyngeal | 13 |
| abstract_inverted_index.significantly | 217 |
| abstract_inverted_index.thirty‐five | 124 |
| abstract_inverted_index.Seroreactivity | 182 |
| abstract_inverted_index.seropositivity | 21, 58, 111, 137 |
| abstract_inverted_index.papillomavirus–driven | 12 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5040450337 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 15 |
| corresponding_institution_ids | https://openalex.org/I143302722, https://openalex.org/I2802239656 |
| citation_normalized_percentile |