The association between metals, vitamin D and preterm birth in the MIREC Cohort Study Article Swipe
Mandy Fisher
,
Leonora Marro
,
Tye E. Arbuckle
,
Beth K. Potter
,
Julian Little
,
Hope A. Weiler
,
Anne‐Sophie Morisset
,
Bruce P. Lanphear
,
Youssef Oulhote
,
Joseph M. Braun
,
Premkumari Kumarathasan
,
Mark Walker
,
Michael M. Borghese
,
Jillian Ashley‐Martin
,
Robin Shutt
,
William D. Fraser
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1289/isee.2022.p-1198
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1289/isee.2022.p-1198
BACKGROUND Toxic metals, like lead, are risk factors for preterm birth (PTB), but few studies have explored this association at the low levels currently found in the Canadian population. Conversely, studies suggest that vitamin D may have antioxidant activity and protect against PTB. In this study, we sought to investigate associations between toxic metals (lead, mercury, cadmium and arsenic) and PTB, and to determine if maternal plasma vitamin D concentrations modify these associations. METHODS We investigated whether metals in whole blood measured in early and late pregnancy were associated with PTB (<37 weeks) and spontaneous PTB (a subset of PTBs with spontaneous labour) in 1,851 pregnancies resulting in live births from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) using discrete time survival analysis. In addition, we investigated whether the risk of PTB was modified by plasma 25OHD concentration measured in the 1st trimester. RESULTS Six percent (n=117) of live births in the MIREC study were PTBs; 4% (n=89) were spontaneous PTBs. A 1 μg/dL increase in blood lead concentrations during pregnancy was associated with increased risk of PTB (OR=1.5, 95% CI: 1.0, 2.3) and spontaneous PTB (OR=1.7, 95% CI: 1.1, 2.8). In stratified analysis, the risk of PTB (OR=2.7, 95% CI: 1.0, 7.2) and spontaneous PTB (OR=3.4, 95% CI: 1.1, 10.8) was higher in women with insufficient vitamin D concentrations (25OHD <50 nmol/L). However, a statistical interaction was not seen. Arsenic was associated with a higher risk of PTB (OR=1.1, 95% CI: 1.0, 1.2) and spontaneous PTB (OR=1.1, 95% CI: 1.0, 1.2) per µg/L, but these associations were not modified by vitamin D. CONCLUSIONS Low levels of lead and arsenic may increase the risk of PTB and spontaneous PTB; the association with lead was stronger in participants with insufficient plasma vitamin D. Replication of these findings is warranted.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1289/isee.2022.p-1198
- OA Status
- diamond
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4320065699
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4320065699Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1289/isee.2022.p-1198Digital Object Identifier
- Title
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The association between metals, vitamin D and preterm birth in the MIREC Cohort StudyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-09-18Full publication date if available
- Authors
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Mandy Fisher, Leonora Marro, Tye E. Arbuckle, Beth K. Potter, Julian Little, Hope A. Weiler, Anne‐Sophie Morisset, Bruce P. Lanphear, Youssef Oulhote, Joseph M. Braun, Premkumari Kumarathasan, Mark Walker, Michael M. Borghese, Jillian Ashley‐Martin, Robin Shutt, William D. FraserList of authors in order
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https://doi.org/10.1289/isee.2022.p-1198Publisher landing page
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://doi.org/10.1289/isee.2022.p-1198Direct OA link when available
- Concepts
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Medicine, Pregnancy, Cohort study, Vitamin D and neurology, Obstetrics, Population, Offspring, Physiology, Internal medicine, Environmental health, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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