The Association between α-Synuclein and α-Tubulin in Brain Synapses Article Swipe
Alida Amadeo
,
Sara Pizzi
,
Alessandro Comincini
,
Debora Modena
,
Alessandra Maria Calogero
,
Laura Madaschi
,
Gaia Faustini
,
Chiara Rolando
,
Arianna Bellucci
,
Gianni Pezzoli
,
Samanta Mazzetti
,
Graziella Cappelletti
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ijms22179153
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ijms22179153
α-synuclein is a small protein that is mainly expressed in the synaptic terminals of nervous tissue. Although its implication in neurodegeneration is well established, the physiological role of α-synuclein remains elusive. Given its involvement in the modulation of synaptic transmission and the emerging role of microtubules at the synapse, the current study aimed at investigating whether α-synuclein becomes involved with this cytoskeletal component at the presynapse. We first analyzed the expression of α-synuclein and its colocalization with α-tubulin in murine brain. Differences were found between cortical and striatal/midbrain areas, with substantia nigra pars compacta and corpus striatum showing the lowest levels of colocalization. Using a proximity ligation assay, we revealed the direct interaction of α-synuclein with α-tubulin in murine and in human brain. Finally, the previously unexplored interaction of the two proteins in vivo at the synapse was disclosed in murine striatal presynaptic boutons through multiple approaches, from confocal spinning disk to electron microscopy. Collectively, our data strongly suggest that the association with tubulin/microtubules might actually be an important physiological function for α-synuclein in the synapse, thus suggesting its potential role in a neuropathological context.
Related Topics
Concepts
Colocalization
Neuroscience
Substantia nigra
Biology
Pars compacta
Synapse
Context (archaeology)
Microtubule
Neurotransmission
Neurodegeneration
Alpha-synuclein
Cell biology
Tubulin
Dopamine
Parkinson's disease
Pathology
Medicine
Dopaminergic
Biochemistry
Paleontology
Disease
Receptor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms22179153
- https://www.mdpi.com/1422-0067/22/17/9153/pdf?version=1630370391
- OA Status
- gold
- Cited By
- 19
- References
- 80
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3195738414
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3195738414Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms22179153Digital Object Identifier
- Title
-
The Association between α-Synuclein and α-Tubulin in Brain SynapsesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-08-25Full publication date if available
- Authors
-
Alida Amadeo, Sara Pizzi, Alessandro Comincini, Debora Modena, Alessandra Maria Calogero, Laura Madaschi, Gaia Faustini, Chiara Rolando, Arianna Bellucci, Gianni Pezzoli, Samanta Mazzetti, Graziella CappellettiList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms22179153Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/22/17/9153/pdf?version=1630370391Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/22/17/9153/pdf?version=1630370391Direct OA link when available
- Concepts
-
Colocalization, Neuroscience, Substantia nigra, Biology, Pars compacta, Synapse, Context (archaeology), Microtubule, Neurotransmission, Neurodegeneration, Alpha-synuclein, Cell biology, Tubulin, Dopamine, Parkinson's disease, Pathology, Medicine, Dopaminergic, Biochemistry, Paleontology, Disease, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
19Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 6, 2023: 4, 2022: 4, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
80Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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