The benefits of high-intensity physical exercise before and after Parkinson’s disease induction in rats Article Swipe
Silvana Venâncio da Silva
,
Grasiela Mara Moreira
,
Paulo Henrique Almeida Campos-Júnior
,
Laila Cristina Moreira Damázio
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1590/1519-6984.282438
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1590/1519-6984.282438
High-intensity physical activity is a non-pharmacological intervention that has been tested as a treatment for Parkinson’s disease (PD). The objective of the study was to investigate the benefits of high-intensity physical exercise on the number of neurons and astrocytes in a a rat model of Parkinson’s disease submitted to training before and after the inducing injury. Seventy Wistar rats were used, distributed as follows: nine rats trained before PD induction (DP-Exa), nine trained after PD induction (DP-Exd), 10 trained before and after PD induction (DP-Exad), and nine sedentary rats (DP-Sed). There were also the same groups but with the rats exposed to the sham surgery (control). High-intensity physical exercise on a vertical ladder was performed before and/or after PD induction for 5 days/week, 30-45 min a day, for 4 weeks. PD was induced with an electrolytic lesion (AP -4.9, ML 1.7, and DV 8.1). At the end of the experiment, the brain was removed for Nissl staining and immunohistochemistry of glial fibrillary acidid protein (GFAP) in the substantia nigra and striatum. The DP-Exa, Sham-Exa, DP-Exad, and Sham-Exad groups showed a greater number of neurons and higher expression of GFAP in the substantia nigra and stiatum compared with the the DP-Exd, Sham-Exd, DP-Sed, and Sham-Sed groups. Thus, rats that performed high-intensity training before or before and after PD induction had higher densities of neurons and astrocytes.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1590/1519-6984.282438
- OA Status
- gold
- Cited By
- 1
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403380581
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4403380581Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1590/1519-6984.282438Digital Object Identifier
- Title
-
The benefits of high-intensity physical exercise before and after Parkinson’s disease induction in ratsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-01Full publication date if available
- Authors
-
Silvana Venâncio da Silva, Grasiela Mara Moreira, Paulo Henrique Almeida Campos-Júnior, Laila Cristina Moreira DamázioList of authors in order
- Landing page
-
https://doi.org/10.1590/1519-6984.282438Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1590/1519-6984.282438Direct OA link when available
- Concepts
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Substantia nigra, Glial fibrillary acidic protein, Striatum, sed, Parkinson's disease, Nissl body, Endocrinology, Internal medicine, Biology, Lesion, Immunohistochemistry, Intensity (physics), Pathology, Medicine, Disease, Staining, Dopamine, Physics, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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30Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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