The Bilateral Ovariectomy in a Female Animal Exacerbates the Pathogenesis of an Intracranial Aneurysm Article Swipe
Mieko Oka
,
Ono I
,
Kampei Shimizu
,
Mika Kushamae
,
Haruka Miyata
,
Takakazu Kawamata
,
Tomohiro Aoki
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/brainsci10060335
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/brainsci10060335
Considering the poor outcome of subarachnoid hemorrhage (SAH) due to the rupture of intracranial aneurysms (IA), mechanisms underlying the pathogenesis of IAs, especially the rupture of lesions, should be clarified. In the present study, a rat model of IAs in which induced lesions spontaneously ruptured resulting in SAH was used. In this model, the combination of the female sex and the bilateral ovariectomy increased the incidence of SAH, similar to epidemiological evidence in human cases. Importantly, unruptured IA lesions induced in female animals with bilateral ovariectomy were histopathologically similar to ruptured ones in the presence of vasa vasorum and the accumulation of abundant inflammatory cells, suggesting the exacerbation of the disease. The post-stenotic dilatation of the carotid artery was disturbed by the bilateral ovariectomy in female rats, which was restored by hormone replacement therapy. The in vivo study thus suggested the protective effect of estrogen from the ovary on endothelial cells loaded by wall shear stress. β-estradiol or dihydrotestosterone also suppressed the lipopolysaccharide-induced expression of pro-inflammatory genes in cultured macrophages and neutrophils. The results of the present study have thus provided new insights about the process regulating the progression of the disease.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/brainsci10060335
- https://www.mdpi.com/2076-3425/10/6/335/pdf?version=1592302712
- OA Status
- gold
- Cited By
- 14
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3028645232
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Raw OpenAlex JSON
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https://openalex.org/W3028645232Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/brainsci10060335Digital Object Identifier
- Title
-
The Bilateral Ovariectomy in a Female Animal Exacerbates the Pathogenesis of an Intracranial AneurysmWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-05-31Full publication date if available
- Authors
-
Mieko Oka, Ono I, Kampei Shimizu, Mika Kushamae, Haruka Miyata, Takakazu Kawamata, Tomohiro AokiList of authors in order
- Landing page
-
https://doi.org/10.3390/brainsci10060335Publisher landing page
- PDF URL
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https://www.mdpi.com/2076-3425/10/6/335/pdf?version=1592302712Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2076-3425/10/6/335/pdf?version=1592302712Direct OA link when available
- Concepts
-
Medicine, Pathogenesis, Vasa vasorum, Subarachnoid hemorrhage, Dihydrotestosterone, Exacerbation, Estrogen, Internal medicine, Aneurysm, Pathology, Endocrinology, Cardiology, Hormone, Surgery, AndrogenTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
14Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 1, 2023: 1, 2022: 6, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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35Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.histopathologically | 87 |
| abstract_inverted_index.lipopolysaccharide-induced | 162 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5046636426 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I2802003475, https://openalex.org/I4210111404 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8199999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.79948431 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |