The Biological Effects of Ozone Gas on Soft and Hard Dental Tissues and the Impact on Human Gingival Fibroblasts and Gingival Keratinocytes Article Swipe

PDF

Alin Daniel Floare , Alexandra-Denisa Semenescu , Octavia Bălean , Doina Chioran , Roxana Buzatu , Ruxandra Sava-Roşianu , Vlad Tiberiu Alexa , Daniela Jumanca , Laura Cristina Rusu , Robert Cosmin Racea , Dorina Coricovac , Iulia Pînzaru , Cristina Dehelean , Atena Găluşcan ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.3390/pr9111978

Ozone is an allotropic form of oxygen, so in the medical field ozone therapy has special effects. Starting from the premise that bio-oxidative ozone therapy reduces the number of bacteria, in the present study two approaches were proposed: to evaluate the biological effects of ozone gas on the tooth enamel remineralization process and to demonstrate its impact on the morphology and confluence of human primary gingival cells, namely keratinocytes (PGK) and fibroblasts (HGF). The ozone produced by HealOzone was applied in vivo to 68 M1s (first permanent molars), both maxillary and mandibular, on the occlusal surfaces at pit and fissure. The molars included in the study recorded values between 13 and 24 according to the DIAGNOdent Pen 2190 scale, this being the main inclusion/exclusion criterion for the investigated molars. Because the gas can make contact with primary gingival cells during the ozonation process, both human gingival fibroblasts and keratinocytes were exposed to different doses of ozone (20 s, 40 s, 60 s), and its effects were observed with the Olympus IX73 inverted microscope. The contact of ozone with the human primary gingival cells demonstrates cell sensitivity to the action of ozone, this being higher in fibroblasts compared to keratinocytes, but it is not considered toxic because all the changes are reversible at 48 h after exposure.

Related Topics

Concepts

Molar Ozone Enamel paint Dentistry Chemistry Human skin Medicine Biology Organic chemistry Genetics

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.3390/pr9111978
PDF: https://www.mdpi.com/2227-9717/9/11/1978/pdf?version=1636104114
OA Status: gold
Cited By: 9
References: 45
Related Works: 10
OpenAlex ID: https://openalex.org/W3211441031

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W3211441031

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.3390/pr9111978

Digital Object Identifier
Title: The Biological Effects of Ozone Gas on Soft and Hard Dental Tissues and the Impact on Human Gingival Fibroblasts and Gingival Keratinocytes

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2021

Year of publication
Publication date: 2021-11-05

Full publication date if available
Authors: Alin Daniel Floare, Alexandra-Denisa Semenescu, Octavia Bălean, Doina Chioran, Roxana Buzatu, Ruxandra Sava-Roşianu, Vlad Tiberiu Alexa, Daniela Jumanca, Laura Cristina Rusu, Robert Cosmin Racea, Dorina Coricovac, Iulia Pînzaru, Cristina Dehelean, Atena Găluşcan

List of authors in order
Landing page: https://doi.org/10.3390/pr9111978

Publisher landing page
PDF URL: https://www.mdpi.com/2227-9717/9/11/1978/pdf?version=1636104114

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://www.mdpi.com/2227-9717/9/11/1978/pdf?version=1636104114

Direct OA link when available
Concepts: Molar, Ozone, Enamel paint, Dentistry, Chemistry, Human skin, Medicine, Biology, Organic chemistry, Genetics

Top concepts (fields/topics) attached by OpenAlex
Cited by: 9

Total citation count in OpenAlex
Citations by year (recent): 2025: 1, 2024: 5, 2022: 3

Per-year citation counts (last 5 years)
References (count): 45

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W3211441031
doi	https://doi.org/10.3390/pr9111978
ids.doi	https://doi.org/10.3390/pr9111978
ids.mag	3211441031
ids.openalex	https://openalex.org/W3211441031
fwci	1.38267889
type	article
title	The Biological Effects of Ozone Gas on Soft and Hard Dental Tissues and the Impact on Human Gingival Fibroblasts and Gingival Keratinocytes
biblio.issue	11
biblio.volume	9
biblio.last_page	1978
biblio.first_page	1978
topics[0].id	https://openalex.org/T13365
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	1.0
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2736
topics[0].subfield.display_name	Pharmacology
topics[0].display_name	Medical and Biological Ozone Research
topics[1].id	https://openalex.org/T13775
topics[1].field.id	https://openalex.org/fields/27
topics[1].field.display_name	Medicine
topics[1].score	0.9699000120162964
topics[1].domain.id	https://openalex.org/domains/4
topics[1].domain.display_name	Health Sciences
topics[1].subfield.id	https://openalex.org/subfields/2746
topics[1].subfield.display_name	Surgery
topics[1].display_name	Hydrogen's biological and therapeutic effects
topics[2].id	https://openalex.org/T11566
topics[2].field.id	https://openalex.org/fields/27
topics[2].field.display_name	Medicine
topics[2].score	0.9592000246047974
topics[2].domain.id	https://openalex.org/domains/4
topics[2].domain.display_name	Health Sciences
topics[2].subfield.id	https://openalex.org/subfields/2741
topics[2].subfield.display_name	Radiology, Nuclear Medicine and Imaging
topics[2].display_name	Laser Applications in Dentistry and Medicine
is_xpac	False
apc_list.value	2000
apc_list.currency	CHF
apc_list.value_usd	2165
apc_paid.value	2000
apc_paid.currency	CHF
apc_paid.value_usd	2165
concepts[0].id	https://openalex.org/C202271784
concepts[0].level	2
concepts[0].score	0.7122462391853333
concepts[0].wikidata	https://www.wikidata.org/wiki/Q189218
concepts[0].display_name	Molar
concepts[1].id	https://openalex.org/C508106653
concepts[1].level	2
concepts[1].score	0.6880311369895935
concepts[1].wikidata	https://www.wikidata.org/wiki/Q36933
concepts[1].display_name	Ozone
concepts[2].id	https://openalex.org/C156887251
concepts[2].level	2
concepts[2].score	0.620008647441864
concepts[2].wikidata	https://www.wikidata.org/wiki/Q2386424
concepts[2].display_name	Enamel paint
concepts[3].id	https://openalex.org/C199343813
concepts[3].level	1
concepts[3].score	0.6121047735214233
concepts[3].wikidata	https://www.wikidata.org/wiki/Q12128
concepts[3].display_name	Dentistry
concepts[4].id	https://openalex.org/C185592680
concepts[4].level	0
concepts[4].score	0.5283128619194031
concepts[4].wikidata	https://www.wikidata.org/wiki/Q2329
concepts[4].display_name	Chemistry
concepts[5].id	https://openalex.org/C2777459323
concepts[5].level	2
concepts[5].score	0.4653893709182739
concepts[5].wikidata	https://www.wikidata.org/wiki/Q5259911
concepts[5].display_name	Human skin
concepts[6].id	https://openalex.org/C71924100
concepts[6].level	0
concepts[6].score	0.23926186561584473
concepts[6].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[6].display_name	Medicine
concepts[7].id	https://openalex.org/C86803240
concepts[7].level	0
concepts[7].score	0.20089289546012878
concepts[7].wikidata	https://www.wikidata.org/wiki/Q420
concepts[7].display_name	Biology
concepts[8].id	https://openalex.org/C178790620
concepts[8].level	1
concepts[8].score	0.0
concepts[8].wikidata	https://www.wikidata.org/wiki/Q11351
concepts[8].display_name	Organic chemistry
concepts[9].id	https://openalex.org/C54355233
concepts[9].level	1
concepts[9].score	0.0
concepts[9].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[9].display_name	Genetics
keywords[0].id	https://openalex.org/keywords/molar
keywords[0].score	0.7122462391853333
keywords[0].display_name	Molar
keywords[1].id	https://openalex.org/keywords/ozone
keywords[1].score	0.6880311369895935
keywords[1].display_name	Ozone
keywords[2].id	https://openalex.org/keywords/enamel-paint
keywords[2].score	0.620008647441864
keywords[2].display_name	Enamel paint
keywords[3].id	https://openalex.org/keywords/dentistry
keywords[3].score	0.6121047735214233
keywords[3].display_name	Dentistry
keywords[4].id	https://openalex.org/keywords/chemistry
keywords[4].score	0.5283128619194031
keywords[4].display_name	Chemistry
keywords[5].id	https://openalex.org/keywords/human-skin
keywords[5].score	0.4653893709182739
keywords[5].display_name	Human skin
keywords[6].id	https://openalex.org/keywords/medicine
keywords[6].score	0.23926186561584473
keywords[6].display_name	Medicine
keywords[7].id	https://openalex.org/keywords/biology
keywords[7].score	0.20089289546012878
keywords[7].display_name	Biology
language	en
locations[0].id	doi:10.3390/pr9111978
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4210201879
locations[0].source.issn	2227-9717
locations[0].source.type	journal
locations[0].source.is_oa	True
locations[0].source.issn_l	2227-9717
locations[0].source.is_core	True
locations[0].source.is_in_doaj	False
locations[0].source.display_name	Processes
locations[0].source.host_organization	https://openalex.org/P4310310987
locations[0].source.host_organization_name	Multidisciplinary Digital Publishing Institute
locations[0].source.host_organization_lineage	https://openalex.org/P4310310987
locations[0].license	cc-by
locations[0].pdf_url	https://www.mdpi.com/2227-9717/9/11/1978/pdf?version=1636104114
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	Processes
locations[0].landing_page_url	https://doi.org/10.3390/pr9111978
locations[1].id	pmh:oai:doaj.org/article:001ecd00d21143c782a13cf26df389c3
locations[1].is_oa	True
locations[1].source.id	https://openalex.org/S4306401280
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	DOAJ (DOAJ: Directory of Open Access Journals)
locations[1].source.host_organization
locations[1].source.host_organization_name
locations[1].source.host_organization_lineage
locations[1].license	cc-by-sa
locations[1].pdf_url
locations[1].version	submittedVersion
locations[1].raw_type	article
locations[1].license_id	https://openalex.org/licenses/cc-by-sa
locations[1].is_accepted	False
locations[1].is_published	False
locations[1].raw_source_name	Processes, Vol 9, Iss 1978, p 1978 (2021)
locations[1].landing_page_url	https://doaj.org/article/001ecd00d21143c782a13cf26df389c3
locations[2].id	pmh:oai:mdpi.com:/2227-9717/9/11/1978/
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S4306400947
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	True
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	MDPI (MDPI AG)
locations[2].source.host_organization	https://openalex.org/I4210097602
locations[2].source.host_organization_name	Multidisciplinary Digital Publishing Institute (Switzerland)
locations[2].source.host_organization_lineage	https://openalex.org/I4210097602
locations[2].license	cc-by
locations[2].pdf_url
locations[2].version	submittedVersion
locations[2].raw_type	Text
locations[2].license_id	https://openalex.org/licenses/cc-by
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name	Processes; Volume 9; Issue 11; Pages: 1978
locations[2].landing_page_url	https://dx.doi.org/10.3390/pr9111978
indexed_in	crossref, doaj
authorships[0].author.id	https://openalex.org/A5034142766
authorships[0].author.orcid
authorships[0].author.display_name	Alin Daniel Floare
authorships[0].countries	RO
authorships[0].affiliations[0].institution_ids	https://openalex.org/I4210088791
authorships[0].affiliations[0].raw_affiliation_string	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[0].institutions[0].id	https://openalex.org/I4210088791
authorships[0].institutions[0].ror	https://ror.org/00afdp487
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I4210088791
authorships[0].institutions[0].country_code	RO
authorships[0].institutions[0].display_name	Victor Babeș University of Medicine and Pharmacy Timișoara
authorships[0].author_position	first
authorships[0].raw_author_name	Alin Daniel Floare
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[1].author.id	https://openalex.org/A5013072820
authorships[1].author.orcid	https://orcid.org/0000-0001-7718-4168
authorships[1].author.display_name	Alexandra-Denisa Semenescu
authorships[1].countries	RO
authorships[1].affiliations[0].institution_ids	https://openalex.org/I4210088791
authorships[1].affiliations[0].raw_affiliation_string	Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[1].affiliations[1].institution_ids	https://openalex.org/I4210088791
authorships[1].affiliations[1].raw_affiliation_string	Department of Toxicology, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[1].institutions[0].id	https://openalex.org/I4210088791
authorships[1].institutions[0].ror	https://ror.org/00afdp487
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I4210088791
authorships[1].institutions[0].country_code	RO
authorships[1].institutions[0].display_name	Victor Babeș University of Medicine and Pharmacy Timișoara
authorships[1].author_position	middle
authorships[1].raw_author_name	Alexandra Denisa Scurtu
authorships[1].is_corresponding	True
authorships[1].raw_affiliation_strings	Department of Toxicology, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania, Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[2].author.id	https://openalex.org/A5047222454
authorships[2].author.orcid	https://orcid.org/0000-0002-9946-2517
authorships[2].author.display_name	Octavia Bălean
authorships[2].countries	RO
authorships[2].affiliations[0].institution_ids	https://openalex.org/I4210088791
authorships[2].affiliations[0].raw_affiliation_string	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[2].affiliations[1].raw_affiliation_string	Translational and Experimental Clinical Research Center in Oral Health (TEXC-OH), 14A Tudor Vladimirescu Ave., 300173 Timisoara, Romania
authorships[2].institutions[0].id	https://openalex.org/I4210088791
authorships[2].institutions[0].ror	https://ror.org/00afdp487
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I4210088791
authorships[2].institutions[0].country_code	RO
authorships[2].institutions[0].display_name	Victor Babeș University of Medicine and Pharmacy Timișoara
authorships[2].author_position	middle
authorships[2].raw_author_name	Octavia Iulia Balean
authorships[2].is_corresponding	True
authorships[2].raw_affiliation_strings	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania, Translational and Experimental Clinical Research Center in Oral Health (TEXC-OH), 14A Tudor Vladimirescu Ave., 300173 Timisoara, Romania
authorships[3].author.id	https://openalex.org/A5057474124
authorships[3].author.orcid	https://orcid.org/0000-0001-7258-7937
authorships[3].author.display_name	Doina Chioran
authorships[3].countries	RO
authorships[3].affiliations[0].institution_ids	https://openalex.org/I4210088791
authorships[3].affiliations[0].raw_affiliation_string	Department II, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[3].institutions[0].id	https://openalex.org/I4210088791
authorships[3].institutions[0].ror	https://ror.org/00afdp487
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I4210088791
authorships[3].institutions[0].country_code	RO
authorships[3].institutions[0].display_name	Victor Babeș University of Medicine and Pharmacy Timișoara
authorships[3].author_position	middle
authorships[3].raw_author_name	Doina Chioran
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Department II, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[4].author.id	https://openalex.org/A5045187803
authorships[4].author.orcid	https://orcid.org/0000-0003-0653-0996
authorships[4].author.display_name	Roxana Buzatu
authorships[4].countries	RO
authorships[4].affiliations[0].institution_ids	https://openalex.org/I4210088791
authorships[4].affiliations[0].raw_affiliation_string	Department II, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[4].institutions[0].id	https://openalex.org/I4210088791
authorships[4].institutions[0].ror	https://ror.org/00afdp487
authorships[4].institutions[0].type	education
authorships[4].institutions[0].lineage	https://openalex.org/I4210088791
authorships[4].institutions[0].country_code	RO
authorships[4].institutions[0].display_name	Victor Babeș University of Medicine and Pharmacy Timișoara
authorships[4].author_position	middle
authorships[4].raw_author_name	Roxana Buzatu
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	Department II, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[5].author.id	https://openalex.org/A5037458649
authorships[5].author.orcid	https://orcid.org/0000-0002-0244-2609
authorships[5].author.display_name	Ruxandra Sava-Roşianu
authorships[5].countries	RO
authorships[5].affiliations[0].institution_ids	https://openalex.org/I4210088791
authorships[5].affiliations[0].raw_affiliation_string	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[5].affiliations[1].raw_affiliation_string	Translational and Experimental Clinical Research Center in Oral Health (TEXC-OH), 14A Tudor Vladimirescu Ave., 300173 Timisoara, Romania
authorships[5].institutions[0].id	https://openalex.org/I4210088791
authorships[5].institutions[0].ror	https://ror.org/00afdp487
authorships[5].institutions[0].type	education
authorships[5].institutions[0].lineage	https://openalex.org/I4210088791
authorships[5].institutions[0].country_code	RO
authorships[5].institutions[0].display_name	Victor Babeș University of Medicine and Pharmacy Timișoara
authorships[5].author_position	middle
authorships[5].raw_author_name	Ruxandra Sava Rosianu
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania, Translational and Experimental Clinical Research Center in Oral Health (TEXC-OH), 14A Tudor Vladimirescu Ave., 300173 Timisoara, Romania
authorships[6].author.id	https://openalex.org/A5084381479
authorships[6].author.orcid	https://orcid.org/0000-0003-3920-6869
authorships[6].author.display_name	Vlad Tiberiu Alexa
authorships[6].countries	RO
authorships[6].affiliations[0].institution_ids	https://openalex.org/I4210088791
authorships[6].affiliations[0].raw_affiliation_string	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[6].institutions[0].id	https://openalex.org/I4210088791
authorships[6].institutions[0].ror	https://ror.org/00afdp487
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I4210088791
authorships[6].institutions[0].country_code	RO
authorships[6].institutions[0].display_name	Victor Babeș University of Medicine and Pharmacy Timișoara
authorships[6].author_position	middle
authorships[6].raw_author_name	Vlad Tiberiu Alexa
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[7].author.id	https://openalex.org/A5050319054
authorships[7].author.orcid	https://orcid.org/0000-0003-2705-5020
authorships[7].author.display_name	Daniela Jumanca
authorships[7].countries	RO
authorships[7].affiliations[0].institution_ids	https://openalex.org/I4210088791
authorships[7].affiliations[0].raw_affiliation_string	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[7].affiliations[1].raw_affiliation_string	Translational and Experimental Clinical Research Center in Oral Health (TEXC-OH), 14A Tudor Vladimirescu Ave., 300173 Timisoara, Romania
authorships[7].institutions[0].id	https://openalex.org/I4210088791
authorships[7].institutions[0].ror	https://ror.org/00afdp487
authorships[7].institutions[0].type	education
authorships[7].institutions[0].lineage	https://openalex.org/I4210088791
authorships[7].institutions[0].country_code	RO
authorships[7].institutions[0].display_name	Victor Babeș University of Medicine and Pharmacy Timișoara
authorships[7].author_position	middle
authorships[7].raw_author_name	Daniela Jumanca
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania, Translational and Experimental Clinical Research Center in Oral Health (TEXC-OH), 14A Tudor Vladimirescu Ave., 300173 Timisoara, Romania
authorships[8].author.id	https://openalex.org/A5056885972
authorships[8].author.orcid	https://orcid.org/0000-0001-6375-4705
authorships[8].author.display_name	Laura Cristina Rusu
authorships[8].countries	RO
authorships[8].affiliations[0].institution_ids	https://openalex.org/I4210088791
authorships[8].affiliations[0].raw_affiliation_string	Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[8].affiliations[1].institution_ids	https://openalex.org/I4210088791
authorships[8].affiliations[1].raw_affiliation_string	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[8].institutions[0].id	https://openalex.org/I4210088791
authorships[8].institutions[0].ror	https://ror.org/00afdp487
authorships[8].institutions[0].type	education
authorships[8].institutions[0].lineage	https://openalex.org/I4210088791
authorships[8].institutions[0].country_code	RO
authorships[8].institutions[0].display_name	Victor Babeș University of Medicine and Pharmacy Timișoara
authorships[8].author_position	middle
authorships[8].raw_author_name	Laura-Cristina Rusu
authorships[8].is_corresponding	False
authorships[8].raw_affiliation_strings	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[9].author.id	https://openalex.org/A5001094919
authorships[9].author.orcid
authorships[9].author.display_name	Robert Cosmin Racea
authorships[9].countries	RO
authorships[9].affiliations[0].institution_ids	https://openalex.org/I4210088791
authorships[9].affiliations[0].raw_affiliation_string	Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[9].affiliations[1].institution_ids	https://openalex.org/I4210088791
authorships[9].affiliations[1].raw_affiliation_string	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[9].institutions[0].id	https://openalex.org/I4210088791
authorships[9].institutions[0].ror	https://ror.org/00afdp487
authorships[9].institutions[0].type	education
authorships[9].institutions[0].lineage	https://openalex.org/I4210088791
authorships[9].institutions[0].country_code	RO
authorships[9].institutions[0].display_name	Victor Babeș University of Medicine and Pharmacy Timișoara
authorships[9].author_position	middle
authorships[9].raw_author_name	Robert Cosmin Racea
authorships[9].is_corresponding	False
authorships[9].raw_affiliation_strings	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[10].author.id	https://openalex.org/A5070763192
authorships[10].author.orcid	https://orcid.org/0000-0002-5760-8872
authorships[10].author.display_name	Dorina Coricovac
authorships[10].countries	RO
authorships[10].affiliations[0].institution_ids	https://openalex.org/I4210088791
authorships[10].affiliations[0].raw_affiliation_string	Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[10].affiliations[1].institution_ids	https://openalex.org/I4210088791
authorships[10].affiliations[1].raw_affiliation_string	Department of Toxicology, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[10].institutions[0].id	https://openalex.org/I4210088791
authorships[10].institutions[0].ror	https://ror.org/00afdp487
authorships[10].institutions[0].type	education
authorships[10].institutions[0].lineage	https://openalex.org/I4210088791
authorships[10].institutions[0].country_code	RO
authorships[10].institutions[0].display_name	Victor Babeș University of Medicine and Pharmacy Timișoara
authorships[10].author_position	middle
authorships[10].raw_author_name	Dorina Coricovac
authorships[10].is_corresponding	False
authorships[10].raw_affiliation_strings	Department of Toxicology, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania, Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[11].author.id	https://openalex.org/A5084166074
authorships[11].author.orcid	https://orcid.org/0000-0003-2295-1926
authorships[11].author.display_name	Iulia Pînzaru
authorships[11].countries	RO
authorships[11].affiliations[0].institution_ids	https://openalex.org/I4210088791
authorships[11].affiliations[0].raw_affiliation_string	Department of Toxicology, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[11].affiliations[1].institution_ids	https://openalex.org/I4210088791
authorships[11].affiliations[1].raw_affiliation_string	Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[11].institutions[0].id	https://openalex.org/I4210088791
authorships[11].institutions[0].ror	https://ror.org/00afdp487
authorships[11].institutions[0].type	education
authorships[11].institutions[0].lineage	https://openalex.org/I4210088791
authorships[11].institutions[0].country_code	RO
authorships[11].institutions[0].display_name	Victor Babeș University of Medicine and Pharmacy Timișoara
authorships[11].author_position	middle
authorships[11].raw_author_name	Iulia Pinzaru
authorships[11].is_corresponding	False
authorships[11].raw_affiliation_strings	Department of Toxicology, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania, Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[12].author.id	https://openalex.org/A5015552254
authorships[12].author.orcid	https://orcid.org/0000-0002-5482-7092
authorships[12].author.display_name	Cristina Dehelean
authorships[12].countries	RO
authorships[12].affiliations[0].institution_ids	https://openalex.org/I4210088791
authorships[12].affiliations[0].raw_affiliation_string	Department of Toxicology, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[12].affiliations[1].institution_ids	https://openalex.org/I4210088791
authorships[12].affiliations[1].raw_affiliation_string	Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[12].institutions[0].id	https://openalex.org/I4210088791
authorships[12].institutions[0].ror	https://ror.org/00afdp487
authorships[12].institutions[0].type	education
authorships[12].institutions[0].lineage	https://openalex.org/I4210088791
authorships[12].institutions[0].country_code	RO
authorships[12].institutions[0].display_name	Victor Babeș University of Medicine and Pharmacy Timișoara
authorships[12].author_position	middle
authorships[12].raw_author_name	Cristina Adriana Dehelean
authorships[12].is_corresponding	False
authorships[12].raw_affiliation_strings	Department of Toxicology, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania, Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[13].author.id	https://openalex.org/A5002344554
authorships[13].author.orcid	https://orcid.org/0000-0001-6046-2336
authorships[13].author.display_name	Atena Găluşcan
authorships[13].countries	RO
authorships[13].affiliations[0].raw_affiliation_string	Translational and Experimental Clinical Research Center in Oral Health (TEXC-OH), 14A Tudor Vladimirescu Ave., 300173 Timisoara, Romania
authorships[13].affiliations[1].institution_ids	https://openalex.org/I4210088791
authorships[13].affiliations[1].raw_affiliation_string	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
authorships[13].institutions[0].id	https://openalex.org/I4210088791
authorships[13].institutions[0].ror	https://ror.org/00afdp487
authorships[13].institutions[0].type	education
authorships[13].institutions[0].lineage	https://openalex.org/I4210088791
authorships[13].institutions[0].country_code	RO
authorships[13].institutions[0].display_name	Victor Babeș University of Medicine and Pharmacy Timișoara
authorships[13].author_position	last
authorships[13].raw_author_name	Atena Galuscan
authorships[13].is_corresponding	False
authorships[13].raw_affiliation_strings	Departament I, Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania, Translational and Experimental Clinical Research Center in Oral Health (TEXC-OH), 14A Tudor Vladimirescu Ave., 300173 Timisoara, Romania
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://www.mdpi.com/2227-9717/9/11/1978/pdf?version=1636104114
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2021-11-22T00:00:00
display_name	The Biological Effects of Ozone Gas on Soft and Hard Dental Tissues and the Impact on Human Gingival Fibroblasts and Gingival Keratinocytes
has_fulltext	True
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T13365
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	1.0
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2736
primary_topic.subfield.display_name	Pharmacology
primary_topic.display_name	Medical and Biological Ozone Research
related_works	https://openalex.org/W862679594, https://openalex.org/W2362787756, https://openalex.org/W2088589483, https://openalex.org/W1972403261, https://openalex.org/W2765954505, https://openalex.org/W2109859129, https://openalex.org/W349792290, https://openalex.org/W1963602507, https://openalex.org/W2243476393, https://openalex.org/W2419887497
cited_by_count	9
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	1
counts_by_year[1].year	2024
counts_by_year[1].cited_by_count	5
counts_by_year[2].year	2022
counts_by_year[2].cited_by_count	3
locations_count	3
best_oa_location.id	doi:10.3390/pr9111978
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4210201879
best_oa_location.source.issn	2227-9717
best_oa_location.source.type	journal
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l	2227-9717
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	Processes
best_oa_location.source.host_organization	https://openalex.org/P4310310987
best_oa_location.source.host_organization_name	Multidisciplinary Digital Publishing Institute
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310310987
best_oa_location.license	cc-by
best_oa_location.pdf_url	https://www.mdpi.com/2227-9717/9/11/1978/pdf?version=1636104114
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	Processes
best_oa_location.landing_page_url	https://doi.org/10.3390/pr9111978
primary_location.id	doi:10.3390/pr9111978
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4210201879
primary_location.source.issn	2227-9717
primary_location.source.type	journal
primary_location.source.is_oa	True
primary_location.source.issn_l	2227-9717
primary_location.source.is_core	True
primary_location.source.is_in_doaj	False
primary_location.source.display_name	Processes
primary_location.source.host_organization	https://openalex.org/P4310310987
primary_location.source.host_organization_name	Multidisciplinary Digital Publishing Institute
primary_location.source.host_organization_lineage	https://openalex.org/P4310310987
primary_location.license	cc-by
primary_location.pdf_url	https://www.mdpi.com/2227-9717/9/11/1978/pdf?version=1636104114
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	Processes
primary_location.landing_page_url	https://doi.org/10.3390/pr9111978
publication_date	2021-11-05
publication_year	2021
referenced_works	https://openalex.org/W2161825679, https://openalex.org/W2148107539, https://openalex.org/W2031992938, https://openalex.org/W3038157852, https://openalex.org/W60900988, https://openalex.org/W2888372642, https://openalex.org/W2074952952, https://openalex.org/W2028877487, https://openalex.org/W2133551348, https://openalex.org/W2466776147, https://openalex.org/W2367330198, https://openalex.org/W2079206677, https://openalex.org/W6675896100, https://openalex.org/W2531942360, https://openalex.org/W2098067126, https://openalex.org/W2034972022, https://openalex.org/W2109430713, https://openalex.org/W1523638695, https://openalex.org/W2028771415, https://openalex.org/W6605373582, https://openalex.org/W2160293260, https://openalex.org/W6698169291, https://openalex.org/W2020040741, https://openalex.org/W39640979, https://openalex.org/W2115652433, https://openalex.org/W1996122603, https://openalex.org/W2005600611, https://openalex.org/W2108708117, https://openalex.org/W6768090455, https://openalex.org/W2752218802, https://openalex.org/W2155564524, https://openalex.org/W1561970483, https://openalex.org/W6770342233, https://openalex.org/W2048128511, https://openalex.org/W2123838721, https://openalex.org/W2568078968, https://openalex.org/W249911177, https://openalex.org/W1991413788, https://openalex.org/W2957079251, https://openalex.org/W2106779036, https://openalex.org/W132500181, https://openalex.org/W2990650053, https://openalex.org/W2863082150, https://openalex.org/W2306502076, https://openalex.org/W2975239348
referenced_works_count	45
abstract_inverted_index.h	213
abstract_inverted_index.13	109
abstract_inverted_index.24	111
abstract_inverted_index.40	158
abstract_inverted_index.48	212
abstract_inverted_index.60	160
abstract_inverted_index.68	83
abstract_inverted_index.an	2
abstract_inverted_index.at	96, 211
abstract_inverted_index.by	76
abstract_inverted_index.in	8, 30, 80, 103, 194
abstract_inverted_index.is	1, 201
abstract_inverted_index.it	200
abstract_inverted_index.of	5, 28, 43, 62, 154, 175, 189
abstract_inverted_index.on	46, 57, 92
abstract_inverted_index.s,	157, 159
abstract_inverted_index.so	7
abstract_inverted_index.to	38, 53, 82, 113, 151, 186, 197
abstract_inverted_index.(20	156
abstract_inverted_index.M1s	84
abstract_inverted_index.Pen	116
abstract_inverted_index.The	73, 100, 173
abstract_inverted_index.all	206
abstract_inverted_index.and	52, 60, 70, 90, 98, 110, 147, 162
abstract_inverted_index.are	209
abstract_inverted_index.but	199
abstract_inverted_index.can	132
abstract_inverted_index.for	125
abstract_inverted_index.gas	45, 131
abstract_inverted_index.has	14
abstract_inverted_index.its	55, 163
abstract_inverted_index.not	202
abstract_inverted_index.pit	97
abstract_inverted_index.s),	161
abstract_inverted_index.the	9, 19, 26, 31, 40, 47, 58, 93, 104, 114, 121, 126, 130, 140, 168, 178, 187, 207
abstract_inverted_index.two	34
abstract_inverted_index.was	78
abstract_inverted_index.2190	117
abstract_inverted_index.IX73	170
abstract_inverted_index.both	88, 143
abstract_inverted_index.cell	184
abstract_inverted_index.form	4
abstract_inverted_index.from	18
abstract_inverted_index.main	122
abstract_inverted_index.make	133
abstract_inverted_index.that	21
abstract_inverted_index.this	119, 191
abstract_inverted_index.vivo	81
abstract_inverted_index.were	36, 149, 165
abstract_inverted_index.with	135, 167, 177
abstract_inverted_index.(PGK)	69
abstract_inverted_index.Ozone	0
abstract_inverted_index.after	214
abstract_inverted_index.being	120, 192
abstract_inverted_index.cells	138, 182
abstract_inverted_index.doses	153
abstract_inverted_index.field	11
abstract_inverted_index.human	63, 144, 179
abstract_inverted_index.ozone	12, 23, 44, 74, 155, 176
abstract_inverted_index.study	33, 105
abstract_inverted_index.tooth	48
abstract_inverted_index.toxic	204
abstract_inverted_index.(HGF).	72
abstract_inverted_index.(first	85
abstract_inverted_index.action	188
abstract_inverted_index.cells,	66
abstract_inverted_index.during	139
abstract_inverted_index.enamel	49
abstract_inverted_index.higher	193
abstract_inverted_index.impact	56
abstract_inverted_index.molars	101
abstract_inverted_index.namely	67
abstract_inverted_index.number	27
abstract_inverted_index.ozone,	190
abstract_inverted_index.scale,	118
abstract_inverted_index.values	107
abstract_inverted_index.Because	129
abstract_inverted_index.Olympus	169
abstract_inverted_index.applied	79
abstract_inverted_index.because	205
abstract_inverted_index.between	108
abstract_inverted_index.changes	208
abstract_inverted_index.contact	134, 174
abstract_inverted_index.effects	42, 164
abstract_inverted_index.exposed	150
abstract_inverted_index.medical	10
abstract_inverted_index.molars.	128
abstract_inverted_index.oxygen,	6
abstract_inverted_index.premise	20
abstract_inverted_index.present	32
abstract_inverted_index.primary	64, 136, 180
abstract_inverted_index.process	51
abstract_inverted_index.reduces	25
abstract_inverted_index.special	15
abstract_inverted_index.therapy	13, 24
abstract_inverted_index.Starting	17
abstract_inverted_index.compared	196
abstract_inverted_index.effects.	16
abstract_inverted_index.evaluate	39
abstract_inverted_index.fissure.	99
abstract_inverted_index.gingival	65, 137, 145, 181
abstract_inverted_index.included	102
abstract_inverted_index.inverted	171
abstract_inverted_index.molars),	87
abstract_inverted_index.observed	166
abstract_inverted_index.occlusal	94
abstract_inverted_index.process,	142
abstract_inverted_index.produced	75
abstract_inverted_index.recorded	106
abstract_inverted_index.surfaces	95
abstract_inverted_index.HealOzone	77
abstract_inverted_index.according	112
abstract_inverted_index.bacteria,	29
abstract_inverted_index.criterion	124
abstract_inverted_index.different	152
abstract_inverted_index.exposure.	215
abstract_inverted_index.maxillary	89
abstract_inverted_index.ozonation	141
abstract_inverted_index.permanent	86
abstract_inverted_index.proposed:	37
abstract_inverted_index.DIAGNOdent	115
abstract_inverted_index.allotropic	3
abstract_inverted_index.approaches	35
abstract_inverted_index.biological	41
abstract_inverted_index.confluence	61
abstract_inverted_index.considered	203
abstract_inverted_index.morphology	59
abstract_inverted_index.reversible	210
abstract_inverted_index.demonstrate	54
abstract_inverted_index.fibroblasts	71, 146, 195
abstract_inverted_index.mandibular,	91
abstract_inverted_index.microscope.	172
abstract_inverted_index.sensitivity	185
abstract_inverted_index.demonstrates	183
abstract_inverted_index.investigated	127
abstract_inverted_index.bio-oxidative	22
abstract_inverted_index.keratinocytes	68, 148
abstract_inverted_index.keratinocytes,	198
abstract_inverted_index.remineralization	50
abstract_inverted_index.inclusion/exclusion	123
cited_by_percentile_year.max	98
cited_by_percentile_year.min	91
corresponding_author_ids	https://openalex.org/A5047222454, https://openalex.org/A5013072820
countries_distinct_count	1
institutions_distinct_count	14
corresponding_institution_ids	https://openalex.org/I4210088791
sustainable_development_goals[0].id	https://metadata.un.org/sdg/10
sustainable_development_goals[0].score	0.8100000023841858
sustainable_development_goals[0].display_name	Reduced inequalities
citation_normalized_percentile.value	0.79976025
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False