The BNT162b2 mRNA COVID-19 Vaccine Increases the Contractile Sensitivity to Histamine and Parasympathetic Activation in a Human Ex Vivo Model of Severe Eosinophilic Asthma Article Swipe
Luigino Calzetta
,
Alfredo Chetta
,
Marina Aiello
,
Annalisa Frizzelli
,
Josuel Ora
,
Enrico Melis
,
Francesco Facciolo
,
Lorenzo Ippoliti
,
Andrea Magrini
,
Paola Rogliani
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/vaccines11020282
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/vaccines11020282
The BNT162b2 COVID-19 vaccine is composed of lipid-nanoparticles (LNP) containing the mRNA that encodes for SARS-CoV-2 spike glycoprotein. Bronchospasm has been reported as an early reaction after COVID-19 mRNA vaccines in asthmatic patients. The aim of this study was to investigate the acute impact of BNT162b2 in a human ex vivo model of severe eosinophilic asthma. Passively sensitized human isolated bronchi were challenged with the platelet-activating factor to reproduce ex vivo the hyperresponsiveness of airways of patients suffering from severe eosinophilic asthma. BNT162b2 was tested on the contractile sensitivity to histamine and parasympathetic activation via electrical field stimulation (EFS); some experiments were performed after mRNA denaturation. BNT162b2 increased the resting tone (+11.82 ± 2.27%) and response to histamine in partially contracted tissue (+42.97 ± 9.64%) vs. the control (p < 0.001); it also shifted the concentration-response curve to histamine leftward (0.76 ± 0.09 logarithm) and enhanced the response to EFS (+28.46 ± 4.40%) vs. the control. Denaturation did not significantly modify (p > 0.05) the effect of BNT162b2. BNT162b2 increases the contractile sensitivity to histamine and parasympathetic activation in hyperresponsive airways, a detrimental effect not related to the active component but to some excipient. A possible candidate for the bronchospasm elicited by BNT162b2 could be the polyethylene glycol/macrogol used to produce LNP.
Related Topics
Concepts
Ex vivo
Histamine
Coronavirus disease 2019 (COVID-19)
Medicine
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
2019-20 coronavirus outbreak
Asthma
Messenger RNA
In vivo
Immunology
Internal medicine
Virology
Chemistry
Biology
Biotechnology
Biochemistry
Infectious disease (medical specialty)
Outbreak
Gene
Disease
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/vaccines11020282
- https://www.mdpi.com/2076-393X/11/2/282/pdf?version=1674886165
- OA Status
- gold
- Cited By
- 7
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4318479100
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4318479100Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/vaccines11020282Digital Object Identifier
- Title
-
The BNT162b2 mRNA COVID-19 Vaccine Increases the Contractile Sensitivity to Histamine and Parasympathetic Activation in a Human Ex Vivo Model of Severe Eosinophilic AsthmaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-28Full publication date if available
- Authors
-
Luigino Calzetta, Alfredo Chetta, Marina Aiello, Annalisa Frizzelli, Josuel Ora, Enrico Melis, Francesco Facciolo, Lorenzo Ippoliti, Andrea Magrini, Paola RoglianiList of authors in order
- Landing page
-
https://doi.org/10.3390/vaccines11020282Publisher landing page
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https://www.mdpi.com/2076-393X/11/2/282/pdf?version=1674886165Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2076-393X/11/2/282/pdf?version=1674886165Direct OA link when available
- Concepts
-
Ex vivo, Histamine, Coronavirus disease 2019 (COVID-19), Medicine, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 2019-20 coronavirus outbreak, Asthma, Messenger RNA, In vivo, Immunology, Internal medicine, Virology, Chemistry, Biology, Biotechnology, Biochemistry, Infectious disease (medical specialty), Outbreak, Gene, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 4, 2023: 2Per-year citation counts (last 5 years)
- References (count)
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63Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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