The Burden of Cardiovascular Events According to Cardiovascular Risk Profile in Adults from High-, Middle- and Low-Income Countries Article Swipe
Darryl P. Leong
,
Rita Yusuf
,
Romaina Iqbal
,
Álvaro Avezum
,
Afzalhussein Yusufali
,
Annika Rosengren
,
Jephat Chifamba
,
Fernando Laņas
,
Marı́a Luz Dı́az
,
J. Jaime Miranda
,
Kairat Davletov
,
Erkin М Мirrakhimov
,
Karen Yeates
,
Rasha Khatib
,
Khalid F. AlHabib
,
Sadi Güleç
,
María-José Paucar
,
Patricio López‐Jaramillo
,
Salim Yusuf
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.03.11.24304132
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.03.11.24304132
Background Current strategies to prevent adverse cardiovascular outcomes focus on secondary prevention and primary prevention in high-risk groups. The proportion of events occurring in lower-risk groups globally is unknown. Methods We prospectively documented fatal or non-fatal myocardial infarction, stroke, heart failure, or any other fatal cardiovascular event stratified by history of cardiovascular disease (CVD), and by the INTERHEART and the Framingham risk score in those without prior CVD, in 189,097 adults from 26 high-, middle- and low-income countries. Results Participants mean±SD age was 51±10 years and 59% were women. We observed 14,829 outcome events affecting 8% of the cohort during a median 12.4 years follow-up. Overall, 44% of outcome events occurred in CVD-naive participants at low or intermediate INTERHEART risk and 56% occurred in in CVD-naive participants at non-high Framingham risk. The proportion of adverse cardiovascular outcomes occurring in these lower risk groups was inversely related to country income level and was higher in women (55%) than in men (35%). Conclusions To achieve a substantial population-level reduction in CVD, preventive strategies for CVD are essential in those considered low- or intermediate-risk.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.03.11.24304132
- https://www.medrxiv.org/content/medrxiv/early/2024/03/14/2024.03.11.24304132.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 17
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392799298
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4392799298Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2024.03.11.24304132Digital Object Identifier
- Title
-
The Burden of Cardiovascular Events According to Cardiovascular Risk Profile in Adults from High-, Middle- and Low-Income CountriesWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-14Full publication date if available
- Authors
-
Darryl P. Leong, Rita Yusuf, Romaina Iqbal, Álvaro Avezum, Afzalhussein Yusufali, Annika Rosengren, Jephat Chifamba, Fernando Laņas, Marı́a Luz Dı́az, J. Jaime Miranda, Kairat Davletov, Erkin М Мirrakhimov, Karen Yeates, Rasha Khatib, Khalid F. AlHabib, Sadi Güleç, María-José Paucar, Patricio López‐Jaramillo, Salim YusufList of authors in order
- Landing page
-
https://doi.org/10.1101/2024.03.11.24304132Publisher landing page
- PDF URL
-
https://www.medrxiv.org/content/medrxiv/early/2024/03/14/2024.03.11.24304132.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.medrxiv.org/content/medrxiv/early/2024/03/14/2024.03.11.24304132.full.pdfDirect OA link when available
- Concepts
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Medicine, Framingham Risk Score, Myocardial infarction, Disease, Cohort, Stroke (engine), Cohort study, Cardiovascular event, Population, Framingham Heart Study, Internal medicine, Demography, Environmental health, Sociology, Engineering, Mechanical engineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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17Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.essential | 174 |
| abstract_inverted_index.high-risk | 16 |
| abstract_inverted_index.inversely | 144 |
| abstract_inverted_index.non-fatal | 35 |
| abstract_inverted_index.occurring | 22, 137 |
| abstract_inverted_index.reduction | 166 |
| abstract_inverted_index.secondary | 10 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Framingham | 60, 129 |
| abstract_inverted_index.INTERHEART | 57, 118 |
| abstract_inverted_index.considered | 177 |
| abstract_inverted_index.countries. | 77 |
| abstract_inverted_index.documented | 32 |
| abstract_inverted_index.follow-up. | 104 |
| abstract_inverted_index.low-income | 76 |
| abstract_inverted_index.lower-risk | 24 |
| abstract_inverted_index.myocardial | 36 |
| abstract_inverted_index.prevention | 11, 14 |
| abstract_inverted_index.preventive | 169 |
| abstract_inverted_index.proportion | 19, 132 |
| abstract_inverted_index.strategies | 2, 170 |
| abstract_inverted_index.stratified | 47 |
| abstract_inverted_index.Conclusions | 160 |
| abstract_inverted_index.infarction, | 37 |
| abstract_inverted_index.substantial | 164 |
| abstract_inverted_index.Participants | 79 |
| abstract_inverted_index.intermediate | 117 |
| abstract_inverted_index.participants | 113, 126 |
| abstract_inverted_index.prospectively | 31 |
| abstract_inverted_index.cardiovascular | 6, 45, 51, 135 |
| abstract_inverted_index.population-level | 165 |
| abstract_inverted_index.intermediate-risk. | 180 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5069359085 |
| countries_distinct_count | 16 |
| institutions_distinct_count | 19 |
| corresponding_institution_ids | https://openalex.org/I2802834092, https://openalex.org/I76442945, https://openalex.org/I98251732 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/1 |
| sustainable_development_goals[0].score | 0.6000000238418579 |
| sustainable_development_goals[0].display_name | No poverty |
| citation_normalized_percentile.value | 0.64296188 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |