The Burden of Metastatic Cancer–Induced Bone Pain: A Narrative Review Article Swipe
Ann Colosia
,
Annete Njue
,
Zahid H. Bajwa
,
Erika Dragon
,
R.L. Robinson
,
Kristin M. Sheffield
,
Sheena Thakkar
,
Steven H Richiemer
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.2147/jpr.s371337
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.2147/jpr.s371337
Bone pain is one of the most common forms of pain reported by cancer patients with metastatic disease. We conducted a review of oncology literature to further understand the epidemiology of and treatment approaches for metastatic cancer-induced bone pain and the effect of treatment of painful bone metastases on the patient's quality of life. Two-thirds of patients with advanced, metastatic, or terminal cancer worldwide experience pain. Cancer pain due to bone metastases is the most common form of pain in patients with advanced disease and has been shown to significantly reduce patients' quality of life. Treatment options for cancer pain due to bone metastases include nonsteroidal anti-inflammatory drugs, palliative radiation, bisphosphonates, denosumab, and opioids. Therapies including palliative radiation and opioids have strong evidence supporting their efficacy treating cancer pain due to bone metastases; other therapies, like bisphosphonates and denosumab, do not. There is sufficient evidence that patients who experience pain relief after radiation therapy have improved quality of life; however, a substantial proportion are nonresponders. For those still requiring pain management, even with available analgesics, many patients are undertreated for cancer pain due to bone metastases, indicating an unmet need. The studies in this review were not designed to determine why cancer pain due to bone metastases was undertreated. Studies specifically addressing cancer pain due to bone metastases, rather than general cancer pain, are limited. Additional research is needed to determine patient preferences and physician attitudes regarding choice of analgesic for moderate to severe cancer pain due to bone metastases.
Related Topics
Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.2147/jpr.s371337
- https://www.dovepress.com/getfile.php?fileID=84916
- OA Status
- gold
- Cited By
- 30
- References
- 92
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4307377472
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4307377472Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.2147/jpr.s371337Digital Object Identifier
- Title
-
The Burden of Metastatic Cancer–Induced Bone Pain: A Narrative ReviewWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-10-01Full publication date if available
- Authors
-
Ann Colosia, Annete Njue, Zahid H. Bajwa, Erika Dragon, R.L. Robinson, Kristin M. Sheffield, Sheena Thakkar, Steven H RichiemerList of authors in order
- Landing page
-
https://doi.org/10.2147/jpr.s371337Publisher landing page
- PDF URL
-
https://www.dovepress.com/getfile.php?fileID=84916Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.dovepress.com/getfile.php?fileID=84916Direct OA link when available
- Concepts
-
Medicine, Denosumab, Bone pain, Cancer, Palliative care, Cancer pain, Radiation therapy, Quality of life (healthcare), Bone disease, Osteoporosis, Internal medicine, Oncology, Surgery, NursingTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
30Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10, 2024: 18, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
92Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4307377472 |
|---|---|
| doi | https://doi.org/10.2147/jpr.s371337 |
| ids.doi | https://doi.org/10.2147/jpr.s371337 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/36317162 |
| ids.openalex | https://openalex.org/W4307377472 |
| fwci | 9.0709672 |
| type | review |
| title | The Burden of Metastatic Cancer–Induced Bone Pain: A Narrative Review |
| biblio.issue | |
| biblio.volume | Volume 15 |
| biblio.last_page | 3412 |
| biblio.first_page | 3399 |
| topics[0].id | https://openalex.org/T12108 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2746 |
| topics[0].subfield.display_name | Surgery |
| topics[0].display_name | Management of metastatic bone disease |
| topics[1].id | https://openalex.org/T12379 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9988999962806702 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2730 |
| topics[1].subfield.display_name | Oncology |
| topics[1].display_name | Cancer Diagnosis and Treatment |
| topics[2].id | https://openalex.org/T11199 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9944999814033508 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2703 |
| topics[2].subfield.display_name | Anesthesiology and Pain Medicine |
| topics[2].display_name | Pain Management and Opioid Use |
| is_xpac | False |
| apc_list.value | 2836 |
| apc_list.currency | USD |
| apc_list.value_usd | 2836 |
| apc_paid.value | 2836 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2836 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.9650763273239136 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C2776286101 |
| concepts[1].level | 3 |
| concepts[1].score | 0.852186381816864 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q408283 |
| concepts[1].display_name | Denosumab |
| concepts[2].id | https://openalex.org/C2776139714 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6571549773216248 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q3480107 |
| concepts[2].display_name | Bone pain |
| concepts[3].id | https://openalex.org/C121608353 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6386517286300659 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[3].display_name | Cancer |
| concepts[4].id | https://openalex.org/C2994186709 |
| concepts[4].level | 2 |
| concepts[4].score | 0.6052231788635254 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q29483 |
| concepts[4].display_name | Palliative care |
| concepts[5].id | https://openalex.org/C2778904085 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5910205841064453 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q3712728 |
| concepts[5].display_name | Cancer pain |
| concepts[6].id | https://openalex.org/C509974204 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5083698630332947 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q180507 |
| concepts[6].display_name | Radiation therapy |
| concepts[7].id | https://openalex.org/C2779951463 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4996190071105957 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7268788 |
| concepts[7].display_name | Quality of life (healthcare) |
| concepts[8].id | https://openalex.org/C2776169692 |
| concepts[8].level | 3 |
| concepts[8].score | 0.43982958793640137 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q4941552 |
| concepts[8].display_name | Bone disease |
| concepts[9].id | https://openalex.org/C2776541429 |
| concepts[9].level | 2 |
| concepts[9].score | 0.35938963294029236 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q165328 |
| concepts[9].display_name | Osteoporosis |
| concepts[10].id | https://openalex.org/C126322002 |
| concepts[10].level | 1 |
| concepts[10].score | 0.3422883152961731 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[10].display_name | Internal medicine |
| concepts[11].id | https://openalex.org/C143998085 |
| concepts[11].level | 1 |
| concepts[11].score | 0.32732635736465454 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q162555 |
| concepts[11].display_name | Oncology |
| concepts[12].id | https://openalex.org/C141071460 |
| concepts[12].level | 1 |
| concepts[12].score | 0.32132065296173096 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q40821 |
| concepts[12].display_name | Surgery |
| concepts[13].id | https://openalex.org/C159110408 |
| concepts[13].level | 1 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q121176 |
| concepts[13].display_name | Nursing |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.9650763273239136 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/denosumab |
| keywords[1].score | 0.852186381816864 |
| keywords[1].display_name | Denosumab |
| keywords[2].id | https://openalex.org/keywords/bone-pain |
| keywords[2].score | 0.6571549773216248 |
| keywords[2].display_name | Bone pain |
| keywords[3].id | https://openalex.org/keywords/cancer |
| keywords[3].score | 0.6386517286300659 |
| keywords[3].display_name | Cancer |
| keywords[4].id | https://openalex.org/keywords/palliative-care |
| keywords[4].score | 0.6052231788635254 |
| keywords[4].display_name | Palliative care |
| keywords[5].id | https://openalex.org/keywords/cancer-pain |
| keywords[5].score | 0.5910205841064453 |
| keywords[5].display_name | Cancer pain |
| keywords[6].id | https://openalex.org/keywords/radiation-therapy |
| keywords[6].score | 0.5083698630332947 |
| keywords[6].display_name | Radiation therapy |
| keywords[7].id | https://openalex.org/keywords/quality-of-life |
| keywords[7].score | 0.4996190071105957 |
| keywords[7].display_name | Quality of life (healthcare) |
| keywords[8].id | https://openalex.org/keywords/bone-disease |
| keywords[8].score | 0.43982958793640137 |
| keywords[8].display_name | Bone disease |
| keywords[9].id | https://openalex.org/keywords/osteoporosis |
| keywords[9].score | 0.35938963294029236 |
| keywords[9].display_name | Osteoporosis |
| keywords[10].id | https://openalex.org/keywords/internal-medicine |
| keywords[10].score | 0.3422883152961731 |
| keywords[10].display_name | Internal medicine |
| keywords[11].id | https://openalex.org/keywords/oncology |
| keywords[11].score | 0.32732635736465454 |
| keywords[11].display_name | Oncology |
| keywords[12].id | https://openalex.org/keywords/surgery |
| keywords[12].score | 0.32132065296173096 |
| keywords[12].display_name | Surgery |
| language | en |
| locations[0].id | doi:10.2147/jpr.s371337 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S130650480 |
| locations[0].source.issn | 1178-7090 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1178-7090 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Journal of Pain Research |
| locations[0].source.host_organization | https://openalex.org/P4310320348 |
| locations[0].source.host_organization_name | Dove Medical Press |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320348 |
| locations[0].license | cc-by-nc |
| locations[0].pdf_url | https://www.dovepress.com/getfile.php?fileID=84916 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Pain Research |
| locations[0].landing_page_url | https://doi.org/10.2147/jpr.s371337 |
| locations[1].id | pmid:36317162 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of pain research |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/36317162 |
| locations[2].id | pmh:oai:dovepress.com/79189 |
| locations[2].is_oa | True |
| locations[2].source | |
| locations[2].license | cc-by-nc |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Review |
| locations[2].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.dovepress.com/the-burden-of-metastatic-cancerinduced-bone-pain-a-narrative-review-peer-reviewed-fulltext-article-JPR |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:9617513 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | J Pain Res |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9617513 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5047720879 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-4164-7524 |
| authorships[0].author.display_name | Ann Colosia |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210120329 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Market Access and Outcomes Strategy, RTI Health Solutions, Research Triangle Park, NC, USA |
| authorships[0].institutions[0].id | https://openalex.org/I4210120329 |
| authorships[0].institutions[0].ror | https://ror.org/032nh7f71 |
| authorships[0].institutions[0].type | nonprofit |
| authorships[0].institutions[0].lineage | https://openalex.org/I180297670, https://openalex.org/I4210120329 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | RTI Health Solutions |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Ann Colosia |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Market Access and Outcomes Strategy, RTI Health Solutions, Research Triangle Park, NC, USA |
| authorships[1].author.id | https://openalex.org/A5064388624 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-2458-2685 |
| authorships[1].author.display_name | Annete Njue |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Market Access and Outcomes Strategy, RTI Health Solutions, Manchester, UK |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Annete Njue |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Market Access and Outcomes Strategy, RTI Health Solutions, Manchester, UK |
| authorships[2].author.id | https://openalex.org/A5111985388 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Zahid H. Bajwa |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I168537998 |
| authorships[2].affiliations[0].raw_affiliation_string | Medical Affairs, Eli Lilly and Company, Indianapolis, IN, USA |
| authorships[2].institutions[0].id | https://openalex.org/I168537998 |
| authorships[2].institutions[0].ror | https://ror.org/01qat3289 |
| authorships[2].institutions[0].type | company |
| authorships[2].institutions[0].lineage | https://openalex.org/I168537998 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Eli Lilly (United States) |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Zahid Bajwa |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Medical Affairs, Eli Lilly and Company, Indianapolis, IN, USA |
| authorships[3].author.id | https://openalex.org/A5044806954 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Erika Dragon |
| authorships[3].affiliations[0].raw_affiliation_string | Medical Affairs, Pfizer, Ltd, Budapest, Hungary |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Erika Dragon |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Medical Affairs, Pfizer, Ltd, Budapest, Hungary |
| authorships[4].author.id | https://openalex.org/A5003287843 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-1490-0491 |
| authorships[4].author.display_name | R.L. Robinson |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I168537998 |
| authorships[4].affiliations[0].raw_affiliation_string | Value, Evidence, and Outcomes, Eli Lilly and Company, Indianapolis, IN, USA |
| authorships[4].institutions[0].id | https://openalex.org/I168537998 |
| authorships[4].institutions[0].ror | https://ror.org/01qat3289 |
| authorships[4].institutions[0].type | company |
| authorships[4].institutions[0].lineage | https://openalex.org/I168537998 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Eli Lilly (United States) |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Rebecca L Robinson |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Value, Evidence, and Outcomes, Eli Lilly and Company, Indianapolis, IN, USA |
| authorships[5].author.id | https://openalex.org/A5043605449 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-3940-1795 |
| authorships[5].author.display_name | Kristin M. Sheffield |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I168537998 |
| authorships[5].affiliations[0].raw_affiliation_string | Value, Evidence, and Outcomes, Eli Lilly and Company, Indianapolis, IN, USA |
| authorships[5].institutions[0].id | https://openalex.org/I168537998 |
| authorships[5].institutions[0].ror | https://ror.org/01qat3289 |
| authorships[5].institutions[0].type | company |
| authorships[5].institutions[0].lineage | https://openalex.org/I168537998 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Eli Lilly (United States) |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Kristin M Sheffield |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Value, Evidence, and Outcomes, Eli Lilly and Company, Indianapolis, IN, USA |
| authorships[6].author.id | https://openalex.org/A5022809857 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-7374-9130 |
| authorships[6].author.display_name | Sheena Thakkar |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I180857899, https://openalex.org/I4210166736 |
| authorships[6].affiliations[0].raw_affiliation_string | Patient Health & Impact, Pfizer Inc, New York, NY, USA |
| authorships[6].institutions[0].id | https://openalex.org/I4210166736 |
| authorships[6].institutions[0].ror | https://ror.org/05ppvf150 |
| authorships[6].institutions[0].type | company |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210166736 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Impact Technology Development (United States) |
| authorships[6].institutions[1].id | https://openalex.org/I180857899 |
| authorships[6].institutions[1].ror | https://ror.org/01xdqrp08 |
| authorships[6].institutions[1].type | company |
| authorships[6].institutions[1].lineage | https://openalex.org/I180857899 |
| authorships[6].institutions[1].country_code | US |
| authorships[6].institutions[1].display_name | Pfizer (United States) |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Sheena Thakkar |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Patient Health & Impact, Pfizer Inc, New York, NY, USA |
| authorships[7].author.id | https://openalex.org/A5013099944 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Steven H Richiemer |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I1174212 |
| authorships[7].affiliations[0].raw_affiliation_string | Division of Pain Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA |
| authorships[7].institutions[0].id | https://openalex.org/I1174212 |
| authorships[7].institutions[0].ror | https://ror.org/03taz7m60 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I1174212 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | University of Southern California |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Steven H Richiemer |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Division of Pain Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.dovepress.com/getfile.php?fileID=84916 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | The Burden of Metastatic Cancer–Induced Bone Pain: A Narrative Review |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12108 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2746 |
| primary_topic.subfield.display_name | Surgery |
| primary_topic.display_name | Management of metastatic bone disease |
| related_works | https://openalex.org/W2764266869, https://openalex.org/W4384469755, https://openalex.org/W2337683644, https://openalex.org/W2515402232, https://openalex.org/W2114557627, https://openalex.org/W2947609311, https://openalex.org/W2605480270, https://openalex.org/W2606113946, https://openalex.org/W204521367, https://openalex.org/W4307377472 |
| cited_by_count | 30 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 10 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 18 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 2 |
| locations_count | 4 |
| best_oa_location.id | doi:10.2147/jpr.s371337 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S130650480 |
| best_oa_location.source.issn | 1178-7090 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1178-7090 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Journal of Pain Research |
| best_oa_location.source.host_organization | https://openalex.org/P4310320348 |
| best_oa_location.source.host_organization_name | Dove Medical Press |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320348 |
| best_oa_location.license | cc-by-nc |
| best_oa_location.pdf_url | https://www.dovepress.com/getfile.php?fileID=84916 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Pain Research |
| best_oa_location.landing_page_url | https://doi.org/10.2147/jpr.s371337 |
| primary_location.id | doi:10.2147/jpr.s371337 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S130650480 |
| primary_location.source.issn | 1178-7090 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1178-7090 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Journal of Pain Research |
| primary_location.source.host_organization | https://openalex.org/P4310320348 |
| primary_location.source.host_organization_name | Dove Medical Press |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320348 |
| primary_location.license | cc-by-nc |
| primary_location.pdf_url | https://www.dovepress.com/getfile.php?fileID=84916 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Pain Research |
| primary_location.landing_page_url | https://doi.org/10.2147/jpr.s371337 |
| publication_date | 2022-10-01 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W2606465146, https://openalex.org/W1814843139, https://openalex.org/W2032848451, https://openalex.org/W15495912, https://openalex.org/W2335598274, https://openalex.org/W2099003239, https://openalex.org/W2834719472, https://openalex.org/W2947609311, https://openalex.org/W1975798559, https://openalex.org/W2023966862, https://openalex.org/W2153148011, https://openalex.org/W2894233067, https://openalex.org/W2062687109, https://openalex.org/W2552485690, https://openalex.org/W3016202049, https://openalex.org/W3041330581, https://openalex.org/W2079449116, https://openalex.org/W2842076021, https://openalex.org/W2139976767, https://openalex.org/W2161962336, https://openalex.org/W2222251362, https://openalex.org/W1995140356, https://openalex.org/W2962702096, https://openalex.org/W2946977165, https://openalex.org/W2075167228, https://openalex.org/W2170309090, https://openalex.org/W2769448136, https://openalex.org/W3041301623, https://openalex.org/W2181805884, https://openalex.org/W2038602339, https://openalex.org/W1967675461, https://openalex.org/W2334775477, https://openalex.org/W2319862735, https://openalex.org/W2479968209, https://openalex.org/W2140623567, https://openalex.org/W2027673233, https://openalex.org/W2038446169, https://openalex.org/W2037624654, https://openalex.org/W2061646082, https://openalex.org/W2512570391, https://openalex.org/W2888413331, https://openalex.org/W1980166874, https://openalex.org/W2775007883, https://openalex.org/W2965434914, https://openalex.org/W2150311669, https://openalex.org/W2337210803, https://openalex.org/W2992133987, https://openalex.org/W2161638521, https://openalex.org/W1982729889, https://openalex.org/W2904351479, https://openalex.org/W2084460361, https://openalex.org/W2153528246, https://openalex.org/W2593004724, https://openalex.org/W2308152342, https://openalex.org/W2224941815, https://openalex.org/W1996589664, https://openalex.org/W2137083298, https://openalex.org/W4244642340, https://openalex.org/W2100738529, https://openalex.org/W2113235727, https://openalex.org/W3191662206, https://openalex.org/W2795081227, https://openalex.org/W2579943201, https://openalex.org/W2333486232, https://openalex.org/W3134143485, https://openalex.org/W2802140481, https://openalex.org/W2042759682, https://openalex.org/W1990711952, https://openalex.org/W2296253991, https://openalex.org/W3156415855, https://openalex.org/W2998139576, https://openalex.org/W3171126669, https://openalex.org/W2758210674, https://openalex.org/W3134043436, https://openalex.org/W3012403681, https://openalex.org/W2970380183, https://openalex.org/W3132575245, https://openalex.org/W3204839224, https://openalex.org/W2794286815, https://openalex.org/W3001904064, https://openalex.org/W3159758529, https://openalex.org/W3084384393, https://openalex.org/W3086563955, https://openalex.org/W2809472530, https://openalex.org/W2889178940, https://openalex.org/W2909050180, https://openalex.org/W2894120681, https://openalex.org/W2147095661, https://openalex.org/W2913435012, https://openalex.org/W1973041556, https://openalex.org/W1917158670, https://openalex.org/W70836747 |
| referenced_works_count | 92 |
| abstract_inverted_index.a | 20, 160 |
| abstract_inverted_index.We | 18 |
| abstract_inverted_index.an | 187 |
| abstract_inverted_index.by | 12 |
| abstract_inverted_index.do | 139 |
| abstract_inverted_index.in | 79, 192 |
| abstract_inverted_index.is | 2, 72, 142, 227 |
| abstract_inverted_index.of | 4, 9, 22, 30, 42, 44, 52, 55, 77, 93, 157, 238 |
| abstract_inverted_index.on | 48 |
| abstract_inverted_index.or | 60 |
| abstract_inverted_index.to | 25, 69, 88, 101, 130, 183, 198, 204, 215, 229, 242, 247 |
| abstract_inverted_index.For | 165 |
| abstract_inverted_index.The | 190 |
| abstract_inverted_index.and | 31, 39, 84, 112, 118, 137, 233 |
| abstract_inverted_index.are | 163, 177, 223 |
| abstract_inverted_index.due | 68, 100, 129, 182, 203, 214, 246 |
| abstract_inverted_index.for | 34, 97, 179, 240 |
| abstract_inverted_index.has | 85 |
| abstract_inverted_index.not | 196 |
| abstract_inverted_index.one | 3 |
| abstract_inverted_index.the | 5, 28, 40, 49, 73 |
| abstract_inverted_index.was | 207 |
| abstract_inverted_index.who | 147 |
| abstract_inverted_index.why | 200 |
| abstract_inverted_index.Bone | 0 |
| abstract_inverted_index.been | 86 |
| abstract_inverted_index.bone | 37, 46, 70, 102, 131, 184, 205, 216, 248 |
| abstract_inverted_index.even | 171 |
| abstract_inverted_index.form | 76 |
| abstract_inverted_index.have | 120, 154 |
| abstract_inverted_index.like | 135 |
| abstract_inverted_index.many | 175 |
| abstract_inverted_index.most | 6, 74 |
| abstract_inverted_index.not. | 140 |
| abstract_inverted_index.pain | 1, 10, 38, 67, 78, 99, 128, 149, 169, 181, 202, 213, 245 |
| abstract_inverted_index.than | 219 |
| abstract_inverted_index.that | 145 |
| abstract_inverted_index.this | 193 |
| abstract_inverted_index.were | 195 |
| abstract_inverted_index.with | 15, 57, 81, 172 |
| abstract_inverted_index.There | 141 |
| abstract_inverted_index.after | 151 |
| abstract_inverted_index.forms | 8 |
| abstract_inverted_index.life. | 53, 94 |
| abstract_inverted_index.life; | 158 |
| abstract_inverted_index.need. | 189 |
| abstract_inverted_index.other | 133 |
| abstract_inverted_index.pain, | 222 |
| abstract_inverted_index.pain. | 65 |
| abstract_inverted_index.shown | 87 |
| abstract_inverted_index.still | 167 |
| abstract_inverted_index.their | 124 |
| abstract_inverted_index.those | 166 |
| abstract_inverted_index.unmet | 188 |
| abstract_inverted_index.Cancer | 66 |
| abstract_inverted_index.cancer | 13, 62, 98, 127, 180, 201, 212, 221, 244 |
| abstract_inverted_index.choice | 237 |
| abstract_inverted_index.common | 7, 75 |
| abstract_inverted_index.drugs, | 107 |
| abstract_inverted_index.effect | 41 |
| abstract_inverted_index.needed | 228 |
| abstract_inverted_index.rather | 218 |
| abstract_inverted_index.reduce | 90 |
| abstract_inverted_index.relief | 150 |
| abstract_inverted_index.review | 21, 194 |
| abstract_inverted_index.severe | 243 |
| abstract_inverted_index.strong | 121 |
| abstract_inverted_index.Studies | 209 |
| abstract_inverted_index.disease | 83 |
| abstract_inverted_index.further | 26 |
| abstract_inverted_index.general | 220 |
| abstract_inverted_index.include | 104 |
| abstract_inverted_index.opioids | 119 |
| abstract_inverted_index.options | 96 |
| abstract_inverted_index.painful | 45 |
| abstract_inverted_index.patient | 231 |
| abstract_inverted_index.quality | 51, 92, 156 |
| abstract_inverted_index.studies | 191 |
| abstract_inverted_index.therapy | 153 |
| abstract_inverted_index.advanced | 82 |
| abstract_inverted_index.designed | 197 |
| abstract_inverted_index.disease. | 17 |
| abstract_inverted_index.efficacy | 125 |
| abstract_inverted_index.evidence | 122, 144 |
| abstract_inverted_index.however, | 159 |
| abstract_inverted_index.improved | 155 |
| abstract_inverted_index.limited. | 224 |
| abstract_inverted_index.moderate | 241 |
| abstract_inverted_index.oncology | 23 |
| abstract_inverted_index.opioids. | 113 |
| abstract_inverted_index.patients | 14, 56, 80, 146, 176 |
| abstract_inverted_index.reported | 11 |
| abstract_inverted_index.research | 226 |
| abstract_inverted_index.terminal | 61 |
| abstract_inverted_index.treating | 126 |
| abstract_inverted_index.Therapies | 114 |
| abstract_inverted_index.Treatment | 95 |
| abstract_inverted_index.advanced, | 58 |
| abstract_inverted_index.analgesic | 239 |
| abstract_inverted_index.attitudes | 235 |
| abstract_inverted_index.available | 173 |
| abstract_inverted_index.conducted | 19 |
| abstract_inverted_index.determine | 199, 230 |
| abstract_inverted_index.including | 115 |
| abstract_inverted_index.patient's | 50 |
| abstract_inverted_index.patients' | 91 |
| abstract_inverted_index.physician | 234 |
| abstract_inverted_index.radiation | 117, 152 |
| abstract_inverted_index.regarding | 236 |
| abstract_inverted_index.requiring | 168 |
| abstract_inverted_index.treatment | 32, 43 |
| abstract_inverted_index.worldwide | 63 |
| abstract_inverted_index.Additional | 225 |
| abstract_inverted_index.Two-thirds | 54 |
| abstract_inverted_index.addressing | 211 |
| abstract_inverted_index.approaches | 33 |
| abstract_inverted_index.denosumab, | 111, 138 |
| abstract_inverted_index.experience | 64, 148 |
| abstract_inverted_index.indicating | 186 |
| abstract_inverted_index.literature | 24 |
| abstract_inverted_index.metastases | 47, 71, 103, 206 |
| abstract_inverted_index.metastatic | 16, 35 |
| abstract_inverted_index.palliative | 108, 116 |
| abstract_inverted_index.proportion | 162 |
| abstract_inverted_index.radiation, | 109 |
| abstract_inverted_index.sufficient | 143 |
| abstract_inverted_index.supporting | 123 |
| abstract_inverted_index.therapies, | 134 |
| abstract_inverted_index.understand | 27 |
| abstract_inverted_index.analgesics, | 174 |
| abstract_inverted_index.management, | 170 |
| abstract_inverted_index.metastases, | 185, 217 |
| abstract_inverted_index.metastases. | 249 |
| abstract_inverted_index.metastases; | 132 |
| abstract_inverted_index.metastatic, | 59 |
| abstract_inverted_index.preferences | 232 |
| abstract_inverted_index.substantial | 161 |
| abstract_inverted_index.epidemiology | 29 |
| abstract_inverted_index.nonsteroidal | 105 |
| abstract_inverted_index.specifically | 210 |
| abstract_inverted_index.undertreated | 178 |
| abstract_inverted_index.significantly | 89 |
| abstract_inverted_index.undertreated. | 208 |
| abstract_inverted_index.cancer-induced | 36 |
| abstract_inverted_index.nonresponders. | 164 |
| abstract_inverted_index.bisphosphonates | 136 |
| abstract_inverted_index.bisphosphonates, | 110 |
| abstract_inverted_index.anti-inflammatory | 106 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8100000023841858 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.97784853 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |