The CACNA1C risk allele rs1006737 is associated with age-related prefrontal cortical thinning in bipolar I disorder Article Swipe
Márcio Gerhardt Soeiro‐de‐Souza
,
Beny Lafer
,
Ricardo Alberto Moreno
,
Fabiano G. Nery
,
Thais Chile
,
Kalil T Chaim
,
Cláudia da Costa Leite
,
Rodrigo Machado‐Vieira
,
Maria Concepción García Otaduy
,
Homero Vallada
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1038/tp.2017.57
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1038/tp.2017.57
Calcium channels control the inflow of calcium ions into cells and are involved in diverse cellular functions. The CACNA1C gene polymorphism rs1006737 A allele has been strongly associated with increased risk for bipolar disorder (BD) and with modulation of brain morphology. The medial prefrontal cortex (mPFC) has been widely associated with mood regulation in BD, but the role of this CACNA1C polymorphism in mPFC morphology and brain aging has yet to be elucidated. One hundred seventeen euthymic BD type I subjects were genotyped for CACNA1C rs1006737 and underwent 3 T three-dimensional structural magnetic resonance imaging scans to determine cortical thickness of mPFC components (superior frontal cortex (sFC), medial orbitofrontal cortex (mOFC), caudal anterior cingulate cortex (cACC) and rostral anterior cingulate cortex (rACC)). Carriers of the CACNA1C allele A exhibited greater left mOFC thickness compared to non-carriers. Moreover, CACNA1C A carriers showed age-related cortical thinning of the left cACC, whereas among A non-carriers there was not an effect of age on left cACC cortical thinning. In the sFC, mOFC and rACC (left or right), a negative correlation was observed between age and cortical thickness, regardless of CACNA1C rs1006737 A status. Further studies investigating the direct link between cortical thickness, calcium channel function, apoptosis mechanism and their underlying relationship with aging-associated cognitive decline in BD are warranted.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/tp.2017.57
- https://www.nature.com/articles/tp201757.pdf
- OA Status
- gold
- Cited By
- 52
- References
- 82
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2605681157
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- OpenAlex ID
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https://openalex.org/W2605681157Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/tp.2017.57Digital Object Identifier
- Title
-
The CACNA1C risk allele rs1006737 is associated with age-related prefrontal cortical thinning in bipolar I disorderWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-04-11Full publication date if available
- Authors
-
Márcio Gerhardt Soeiro‐de‐Souza, Beny Lafer, Ricardo Alberto Moreno, Fabiano G. Nery, Thais Chile, Kalil T Chaim, Cláudia da Costa Leite, Rodrigo Machado‐Vieira, Maria Concepción García Otaduy, Homero ValladaList of authors in order
- Landing page
-
https://doi.org/10.1038/tp.2017.57Publisher landing page
- PDF URL
-
https://www.nature.com/articles/tp201757.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/tp201757.pdfDirect OA link when available
- Concepts
-
Prefrontal cortex, Anterior cingulate cortex, Neuroscience, Orbitofrontal cortex, Allele, Bipolar disorder, Cortex (anatomy), Cingulate cortex, Psychology, Internal medicine, Medicine, Cognition, Central nervous system, Biology, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
52Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 5, 2023: 7, 2022: 3, 2021: 24Per-year citation counts (last 5 years)
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82Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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