The CDX2 G allele and the FoKI F allele of the VDR gene are more prevalent and related to changes in vitamin D levels in patients with psoriasis vulgaris: A pilot study Article Swipe

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Ahmed Ibrahim AbdElneam , Mohammed Saleh Al‐Dhubaibi , Saleh Salem Bahaj , Mohammad Arshad , Ghada Farouk Mohammed , Lina Mohamed Atef ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1111/srt.13530

Background and aims Psoriasis is a chronic, non‐contagious autoimmune condition marked by dry, itchy,erythematous and scaly plaques. From modest, localized plaques to total body coverage, the severity of psoriasis varies. Plaque, guttate, inverted, pustular, and erythrodermic psoriasis are the five primary kinds. About 90% of cases are of plaque psoriasis, commonly known as psoriasis vulgaris. Study aims to determine the impact of an rs2228570 (FokI) variant and an rs11568820 (CDX2) variant on serum vitamin D levels (SVD) in patients with psoriasis, and the correlation between the two variants and disease severity. Methods A case‐control study consisting of 95 psoriasis vulgaris patients and 84 healthy controls. The clinical investigation, molecular genetics analysis, and biochemical analysis were done for both groups. Results SVD levels were significantly decreased in psoriasis patients group. FokI genotypes analysis, we found no significant variance between groups. CDX2 G/G genotype is more prevalent in patients than controls. Moderate psoriasis vulgaris patients with CDX2 G/G genotypes have higher SVD levels than CDX2 G/A, and CDX2 A/A p = 0.003. Conclusion The study found a difference in vitamin D levels between patients and healthy subjects, as well as a difference in vitamin D levels with different FoKI and CDX2 genotypes.

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Alejandro Davidovich Fokina

Concepts

FokI Psoriasis Medicine Calcitriol receptor Genotype Vitamin D and neurology Allele Psoriasis Area and Severity Index CDX2 Gastroenterology Gene polymorphism Internal medicine Dermatology Immunology Polymorphism (computer science) Gene Biology Genetics Gene expression Homeobox

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Type: article
Language: en
Landing Page: https://doi.org/10.1111/srt.13530
PDF: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/srt.13530
OA Status: hybrid
Cited By: 6
References: 43
Related Works: 10
OpenAlex ID: https://openalex.org/W4388850820

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DOI: https://doi.org/10.1111/srt.13530

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Title: The CDX2 G allele and the FoKI F allele of the VDR gene are more prevalent and related to changes in vitamin D levels in patients with psoriasis vulgaris: A pilot study

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Type: article

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Language: en

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Publication year: 2023

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Publication date: 2023-11-01

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Authors: Ahmed Ibrahim AbdElneam, Mohammed Saleh Al‐Dhubaibi, Saleh Salem Bahaj, Mohammad Arshad, Ghada Farouk Mohammed, Lina Mohamed Atef

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Landing page: https://doi.org/10.1111/srt.13530

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PDF URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/srt.13530

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Concepts: FokI, Psoriasis, Medicine, Calcitriol receptor, Genotype, Vitamin D and neurology, Allele, Psoriasis Area and Severity Index, CDX2, Gastroenterology, Gene polymorphism, Internal medicine, Dermatology, Immunology, Polymorphism (computer science), Gene, Biology, Genetics, Gene expression, Homeobox

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Cited by: 6

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Citations by year (recent): 2025: 2, 2024: 3, 2023: 1

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