The Central Role of Th2 Immune Response in Inflammatory Dermatoses: From Pathogenesis to Targeted Therapies Article Swipe
Valentina Pala
,
François Rosset
,
Luca Mastorino
,
Nadia Sciamarrelli
,
Sara Boskovic
,
Silvia Borriello
,
Eleonora Bongiovanni
,
Orsola Crespi
,
Simone Ribero
,
Pietro Quaglino
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ijms262110720
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ijms262110720
T helper 2 (Th2)-mediated dermatoses are inflammatory skin diseases driven by CD4+ Th2 cells that produce interleukin (IL)-4, IL-5, IL-13, and IL-31, promoting immunoglobulin E (IgE) class switching, eosinophil recruitment, mast cell degranulation, and pruritus. We aimed to place these conditions in context and clarify how Th2 biology informs diagnosis and therapy. We conducted a narrative synthesis of mechanistic, translational, and clinical evidence on Th2 pathways in atopic dermatitis (AD), prurigo nodularis, bullous pemphigoid, chronic spontaneous urticaria, and selected type I/IVb hypersensitivity reactions, with focused appraisal of trials targeting IL-4Rα, IL-13, and IL-31R. Persistent Th2 activation is associated with epidermal barrier dysfunction, immune dysregulation, and pruritogenic neural signaling; AD is the archetype, showing prominent lesional IL-4/IL-13 activity correlated with severity and itch. Across disorders, pathway-directed biologics against IL-4Rα, IL-13, and IL-31R consistently reduce disease activity and pruritus in AD and prurigo nodularis, with emerging signals of benefit in bullous pemphigoid and chronic spontaneous urticaria. The Th2 axis provides a unifying pathogenic framework and actionable therapeutic target across multiple dermatoses. Integrating cytokine profiling with clinical phenotypes may refine patient stratification and optimize the deployment of existing and next-generation Th2-targeting therapies.
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- Type
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- en
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- 95
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All OpenAlex metadata
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https://doi.org/10.3390/ijms262110720Digital Object Identifier
- Title
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The Central Role of Th2 Immune Response in Inflammatory Dermatoses: From Pathogenesis to Targeted TherapiesWork title
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reviewOpenAlex work type
- Language
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2025Year of publication
- Publication date
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2025-11-04Full publication date if available
- Authors
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Valentina Pala, François Rosset, Luca Mastorino, Nadia Sciamarrelli, Sara Boskovic, Silvia Borriello, Eleonora Bongiovanni, Orsola Crespi, Simone Ribero, Pietro QuaglinoList of authors in order
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https://doi.org/10.3390/ijms262110720Publisher landing page
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https://www.mdpi.com/1422-0067/26/21/10720/pdf?version=1762251263Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/26/21/10720/pdf?version=1762251263Direct OA link when available
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0Total citation count in OpenAlex
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