The Challenges of Renal Cell Carcinoma Metastatic to the Spine: A Systematic Review of Survival and Treatment Article Swipe
C. Rory Goodwin
,
Ali Ahmed
,
Christine Boone
,
Nancy Abu-Bonsrah
,
Risheng Xu
,
Niccole Germscheid
,
Daryl R. Fourney
,
Michelle J. Clarke
,
Ilya Laufer
,
Charles G. Fisher
,
Chetan Bettegowda
,
Daniel M. Sciubba
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1177/2192568217737777
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1177/2192568217737777
Study Design: Systematic review. Objectives: The objective of this systematic review was to answer 2 key questions: (1) What is the clinical presentation and probability of symptomatic improvement following treatment for patients with renal cell carcinoma (RCC) of the spine? (2) What is the overall survival of patients diagnosed with spinal metastases from RCC? Methods: A literature review was performed to identify articles that reported on survival, clinical outcomes, and/or prognostic factors in the RCC population with spinal metastases from 1986 to 2016. Results: Forty-eight articles (807 patients) were included. The Fuhrman Nuclear Grade has been significantly associated with survival in previous studies but was underpowered in the current study. The Memorial Sloan-Kettering Cancer Center Score (MSKCC/Motzer) was also underpowered in the current study. From the time of spinal metastasis, the mean and median survival for patients with previously diagnosed primary RCC was 8.75 and 11.7 months, respectively, whereas synchronously diagnosed patients (primary RCC and spinal metastasis) had a mean and median survival of 6.75 and 11 months, respectively. Patients with a “low” (0-8), “intermediate” (9-11), or “high” (12-15) revised Tokuhashi score at initial presentation had a median survival of 5.4, 11.7, and 32.9 months, respectively. Conclusion: Patients with either a synchronous or latent diagnosis of RCC survived greater than 6 months from the time of presentation. Initial Furhman grade, Tokuhashi score, and MSKCC/Motzer can be useful tools in informing patient-specific prognosis for those with metastatic RCC of the spine.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1177/2192568217737777
- https://journals.sagepub.com/doi/pdf/10.1177/2192568217737777
- OA Status
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- Cited By
- 20
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2770600031
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2770600031Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/2192568217737777Digital Object Identifier
- Title
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The Challenges of Renal Cell Carcinoma Metastatic to the Spine: A Systematic Review of Survival and TreatmentWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2017Year of publication
- Publication date
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2017-11-20Full publication date if available
- Authors
-
C. Rory Goodwin, Ali Ahmed, Christine Boone, Nancy Abu-Bonsrah, Risheng Xu, Niccole Germscheid, Daryl R. Fourney, Michelle J. Clarke, Ilya Laufer, Charles G. Fisher, Chetan Bettegowda, Daniel M. SciubbaList of authors in order
- Landing page
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https://doi.org/10.1177/2192568217737777Publisher landing page
- PDF URL
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https://journals.sagepub.com/doi/pdf/10.1177/2192568217737777Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://journals.sagepub.com/doi/pdf/10.1177/2192568217737777Direct OA link when available
- Concepts
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Medicine, Renal cell carcinoma, SPINE (molecular biology), Oncology, Internal medicine, Bioinformatics, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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20Total citation count in OpenAlex
- Citations by year (recent)
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2024: 4, 2023: 2, 2022: 6, 2021: 3, 2020: 5Per-year citation counts (last 5 years)
- References (count)
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60Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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