The comorbidity of depression and neurocognitive disorder in persons with HIV infection: call for investigation and treatment Article Swipe
Karl Goodkin
,
Teresa H. Evering
,
Albert M. Anderson
,
Ann Ragin
,
Cynthia L. Monaco
,
Christina Gavegnano
,
Ryan Avery
,
Sean B. Rourke
,
Lucette A. Cysique
,
Bruce J. Brew
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fncel.2023.1130938
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fncel.2023.1130938
Depression and neurocognitive disorder continue to be the major neuropsychiatric disorders affecting persons with HIV (PWH). The prevalence of major depressive disorder is two to fourfold higher among PWH than the general population (∼6.7%). Prevalence estimates of neurocognitive disorder among PWH range from 25 to over 47% – depending upon the definition used (which is currently evolving), the size of the test battery employed, and the demographic and HIV disease characteristics of the participants included, such as age range and sex distribution. Both major depressive disorder and neurocognitive disorder also result in substantial morbidity and premature mortality. However, though anticipated to be relatively common, the comorbidity of these two disorders in PWH has not been formally studied. This is partly due to the clinical overlap of the neurocognitive symptoms of these two disorders. Both also share neurobehavioral aspects — particularly apathy — as well as an increased risk for non-adherence to antiretroviral therapy. Shared pathophysiological mechanisms potentially explain these intersecting phenotypes, including neuroinflammatory, vascular, and microbiomic, as well as neuroendocrine/neurotransmitter dynamic mechanisms. Treatment of either disorder affects the other with respect to symptom reduction as well as medication toxicity. We present a unified model for the comorbidity based upon deficits in dopaminergic transmission that occur in both major depressive disorder and HIV-associated neurocognitive disorder. Specific treatments for the comorbidity that decrease neuroinflammation and/or restore associated deficits in dopaminergic transmission may be indicated and merit study.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fncel.2023.1130938
- https://www.frontiersin.org/articles/10.3389/fncel.2023.1130938/pdf?isPublishedV2=False
- OA Status
- gold
- Cited By
- 17
- References
- 183
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4367317909
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4367317909Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fncel.2023.1130938Digital Object Identifier
- Title
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The comorbidity of depression and neurocognitive disorder in persons with HIV infection: call for investigation and treatmentWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-04-28Full publication date if available
- Authors
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Karl Goodkin, Teresa H. Evering, Albert M. Anderson, Ann Ragin, Cynthia L. Monaco, Christina Gavegnano, Ryan Avery, Sean B. Rourke, Lucette A. Cysique, Bruce J. BrewList of authors in order
- Landing page
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https://doi.org/10.3389/fncel.2023.1130938Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fncel.2023.1130938/pdf?isPublishedV2=FalseDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fncel.2023.1130938/pdf?isPublishedV2=FalseDirect OA link when available
- Concepts
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Neurocognitive, Comorbidity, Depression (economics), Human immunodeficiency virus (HIV), Psychiatry, Psychology, Clinical psychology, Medicine, Cognition, Virology, Economics, MacroeconomicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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17Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8, 2024: 6, 2023: 3Per-year citation counts (last 5 years)
- References (count)
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183Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.that | 203, 219 |
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| abstract_inverted_index.well | 143, 167, 185 |
| abstract_inverted_index.with | 13, 179 |
| abstract_inverted_index.among | 27, 39 |
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| abstract_inverted_index.major | 8, 19, 83, 207 |
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| abstract_inverted_index.range | 41, 78 |
| abstract_inverted_index.share | 135 |
| abstract_inverted_index.these | 107, 130, 158 |
| abstract_inverted_index.(PWH). | 15 |
| abstract_inverted_index.(which | 53 |
| abstract_inverted_index.Shared | 153 |
| abstract_inverted_index.and/or | 222 |
| abstract_inverted_index.apathy | 140 |
| abstract_inverted_index.either | 174 |
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| abstract_inverted_index.partly | 119 |
| abstract_inverted_index.result | 90 |
| abstract_inverted_index.study. | 234 |
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| abstract_inverted_index.affects | 176 |
| abstract_inverted_index.aspects | 137 |
| abstract_inverted_index.battery | 62 |
| abstract_inverted_index.common, | 103 |
| abstract_inverted_index.disease | 69 |
| abstract_inverted_index.dynamic | 170 |
| abstract_inverted_index.explain | 157 |
| abstract_inverted_index.general | 31 |
| abstract_inverted_index.overlap | 124 |
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| abstract_inverted_index.symptom | 182 |
| abstract_inverted_index.unified | 192 |
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| abstract_inverted_index.clinical | 123 |
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| abstract_inverted_index.deficits | 199, 225 |
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| abstract_inverted_index.therapy. | 152 |
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| abstract_inverted_index.depending | 48 |
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| abstract_inverted_index.reduction | 183 |
| abstract_inverted_index.toxicity. | 188 |
| abstract_inverted_index.vascular, | 163 |
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| abstract_inverted_index.Depression | 0 |
| abstract_inverted_index.Prevalence | 34 |
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| abstract_inverted_index.depressive | 20, 84, 208 |
| abstract_inverted_index.disorders. | 132 |
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| abstract_inverted_index.neuroinflammatory, | 162 |
| abstract_inverted_index.pathophysiological | 154 |
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| corresponding_author_ids | https://openalex.org/A5052473474 |
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| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I2802326326 |
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