The complement C3‐C3aR pathway mediates microglia–astrocyte interaction following status epilepticus
Article Swipe
Yujia Wei
,
Tingjun Chen
,
Dale B. Bosco
,
Manling Xie
,
Jiaying Zheng
,
Aastha Dheer
,
Yanlu Ying
,
Qian Wu
,
Vanda A. Lennon
,
Long‐Jun Wu
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/glia.23955
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/glia.23955
Gliosis is a histopathological characteristic of epilepsy that comprises activated microglia and astrocytes. It is unclear whether or how crosstalk occurs between microglia and astrocytes in the evolution of epilepsy. Here, we report in a mouse model of status epilepticus, induced by intracerebroventricular injection of kainic acid (KA), sequential activation of microglia and astrocytes and their close spatial interaction in the hippocampal CA3 region. Microglial ablation reduced astrocyte activation and their upregulation of complement C3. When compared to wild‐type mice, both C3 −/− and C3aR −/− mice had significantly less microglia–astrocyte interaction in response to KA‐induced status epilepticus. Additionally, KA‐injected C3 −/− mice had significantly less histochemical evidence of neurodegeneration. The results suggest that the C3‐C3aR pathway contributes to KA‐induced neurodegeneration by mediating microglia–astrocyte communication. The C3‐C3aR pathway may prove to be a potential therapeutic target for epilepsy treatment.
Related Topics
Concepts
Microglia
Astrocyte
Status epilepticus
Biology
Complement (music)
Neuroscience
Complement system
Immunology
Alternative complement pathway
Central nervous system
Epilepsy
Inflammation
Immune system
Genetics
Gene
Complementation
Phenotype
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/glia.23955
- OA Status
- green
- Cited By
- 125
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3113278031
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3113278031Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/glia.23955Digital Object Identifier
- Title
-
The complement
C3‐C3aR pathway mediates microglia–astrocyte interaction following status epilepticusWork title - Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-12-14Full publication date if available
- Authors
-
Yujia Wei, Tingjun Chen, Dale B. Bosco, Manling Xie, Jiaying Zheng, Aastha Dheer, Yanlu Ying, Qian Wu, Vanda A. Lennon, Long‐Jun WuList of authors in order
- Landing page
-
https://doi.org/10.1002/glia.23955Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/7936954Direct OA link when available
- Concepts
-
Microglia, Astrocyte, Status epilepticus, Biology, Complement (music), Neuroscience, Complement system, Immunology, Alternative complement pathway, Central nervous system, Epilepsy, Inflammation, Immune system, Genetics, Gene, Complementation, PhenotypeTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
125Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 39, 2024: 29, 2023: 31, 2022: 18, 2021: 8Per-year citation counts (last 5 years)
- References (count)
-
54Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3113278031 |
|---|---|
| doi | https://doi.org/10.1002/glia.23955 |
| ids.doi | https://doi.org/10.1002/glia.23955 |
| ids.mag | 3113278031 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/33314324 |
| ids.openalex | https://openalex.org/W3113278031 |
| fwci | 6.48255931 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D001253 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Astrocytes |
| mesh[2].qualifier_ui | Q000235 |
| mesh[2].descriptor_ui | D003176 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | genetics |
| mesh[2].descriptor_name | Complement C3 |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D004827 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Epilepsy |
| mesh[4].qualifier_ui | Q000633 |
| mesh[4].descriptor_ui | D007608 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | toxicity |
| mesh[4].descriptor_name | Kainic Acid |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D051379 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Mice |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D017628 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Microglia |
| mesh[7].qualifier_ui | Q000139 |
| mesh[7].descriptor_ui | D013226 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | chemically induced |
| mesh[7].descriptor_name | Status Epilepticus |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D000818 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Animals |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D001253 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Astrocytes |
| mesh[10].qualifier_ui | Q000235 |
| mesh[10].descriptor_ui | D003176 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | genetics |
| mesh[10].descriptor_name | Complement C3 |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D004827 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Epilepsy |
| mesh[12].qualifier_ui | Q000633 |
| mesh[12].descriptor_ui | D007608 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | toxicity |
| mesh[12].descriptor_name | Kainic Acid |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D051379 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Mice |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D017628 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Microglia |
| mesh[15].qualifier_ui | Q000139 |
| mesh[15].descriptor_ui | D013226 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | chemically induced |
| mesh[15].descriptor_name | Status Epilepticus |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D000818 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Animals |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D001253 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Astrocytes |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D003176 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | Complement C3 |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D004827 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Epilepsy |
| mesh[20].qualifier_ui | Q000633 |
| mesh[20].descriptor_ui | D007608 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | toxicity |
| mesh[20].descriptor_name | Kainic Acid |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D051379 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Mice |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D017628 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Microglia |
| mesh[23].qualifier_ui | Q000139 |
| mesh[23].descriptor_ui | D013226 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | chemically induced |
| mesh[23].descriptor_name | Status Epilepticus |
| type | article |
| title | The complement |
| awards[0].id | https://openalex.org/G6429162647 |
| awards[0].funder_id | https://openalex.org/F4320337359 |
| awards[0].display_name | |
| awards[0].funder_award_id | R01NS088627 |
| awards[0].funder_display_name | National Institute of Neurological Disorders and Stroke |
| awards[1].id | https://openalex.org/G2349268311 |
| awards[1].funder_id | https://openalex.org/F4320321001 |
| awards[1].display_name | |
| awards[1].funder_award_id | 81601142 |
| awards[1].funder_display_name | National Natural Science Foundation of China |
| awards[2].id | https://openalex.org/G926904667 |
| awards[2].funder_id | https://openalex.org/F4320337359 |
| awards[2].display_name | |
| awards[2].funder_award_id | R01NS112144 |
| awards[2].funder_display_name | National Institute of Neurological Disorders and Stroke |
| biblio.issue | 5 |
| biblio.volume | 69 |
| biblio.last_page | 1169 |
| biblio.first_page | 1155 |
| topics[0].id | https://openalex.org/T11266 |
| topics[0].field.id | https://openalex.org/fields/28 |
| topics[0].field.display_name | Neuroscience |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2808 |
| topics[0].subfield.display_name | Neurology |
| topics[0].display_name | Neuroinflammation and Neurodegeneration Mechanisms |
| topics[1].id | https://openalex.org/T10993 |
| topics[1].field.id | https://openalex.org/fields/24 |
| topics[1].field.display_name | Immunology and Microbiology |
| topics[1].score | 0.9976000189781189 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2403 |
| topics[1].subfield.display_name | Immunology |
| topics[1].display_name | Complement system in diseases |
| topics[2].id | https://openalex.org/T11184 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9918000102043152 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2735 |
| topics[2].subfield.display_name | Pediatrics, Perinatology and Child Health |
| topics[2].display_name | Neonatal and fetal brain pathology |
| funders[0].id | https://openalex.org/F4320321001 |
| funders[0].ror | https://ror.org/01h0zpd94 |
| funders[0].display_name | National Natural Science Foundation of China |
| funders[1].id | https://openalex.org/F4320337359 |
| funders[1].ror | https://ror.org/01s5ya894 |
| funders[1].display_name | National Institute of Neurological Disorders and Stroke |
| is_xpac | False |
| apc_list.value | 4940 |
| apc_list.currency | USD |
| apc_list.value_usd | 4940 |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2779830541 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8121544122695923 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1622829 |
| concepts[0].display_name | Microglia |
| concepts[1].id | https://openalex.org/C2777542381 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7940303683280945 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q502961 |
| concepts[1].display_name | Astrocyte |
| concepts[2].id | https://openalex.org/C2777341932 |
| concepts[2].level | 3 |
| concepts[2].score | 0.7769399285316467 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q980709 |
| concepts[2].display_name | Status epilepticus |
| concepts[3].id | https://openalex.org/C86803240 |
| concepts[3].level | 0 |
| concepts[3].score | 0.6988902688026428 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[3].display_name | Biology |
| concepts[4].id | https://openalex.org/C112313634 |
| concepts[4].level | 5 |
| concepts[4].score | 0.6586259603500366 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7886648 |
| concepts[4].display_name | Complement (music) |
| concepts[5].id | https://openalex.org/C169760540 |
| concepts[5].level | 1 |
| concepts[5].score | 0.6409859657287598 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[5].display_name | Neuroscience |
| concepts[6].id | https://openalex.org/C111684460 |
| concepts[6].level | 3 |
| concepts[6].score | 0.5463424921035767 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q334848 |
| concepts[6].display_name | Complement system |
| concepts[7].id | https://openalex.org/C203014093 |
| concepts[7].level | 1 |
| concepts[7].score | 0.4773397743701935 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[7].display_name | Immunology |
| concepts[8].id | https://openalex.org/C189446657 |
| concepts[8].level | 4 |
| concepts[8].score | 0.4287509322166443 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q4736500 |
| concepts[8].display_name | Alternative complement pathway |
| concepts[9].id | https://openalex.org/C529278444 |
| concepts[9].level | 2 |
| concepts[9].score | 0.3351081609725952 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q47273 |
| concepts[9].display_name | Central nervous system |
| concepts[10].id | https://openalex.org/C2778186239 |
| concepts[10].level | 2 |
| concepts[10].score | 0.20566225051879883 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q41571 |
| concepts[10].display_name | Epilepsy |
| concepts[11].id | https://openalex.org/C2776914184 |
| concepts[11].level | 2 |
| concepts[11].score | 0.19546523690223694 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[11].display_name | Inflammation |
| concepts[12].id | https://openalex.org/C8891405 |
| concepts[12].level | 2 |
| concepts[12].score | 0.1486382782459259 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[12].display_name | Immune system |
| concepts[13].id | https://openalex.org/C54355233 |
| concepts[13].level | 1 |
| concepts[13].score | 0.09048593044281006 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[13].display_name | Genetics |
| concepts[14].id | https://openalex.org/C104317684 |
| concepts[14].level | 2 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[14].display_name | Gene |
| concepts[15].id | https://openalex.org/C188082640 |
| concepts[15].level | 4 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q1780899 |
| concepts[15].display_name | Complementation |
| concepts[16].id | https://openalex.org/C127716648 |
| concepts[16].level | 3 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q104053 |
| concepts[16].display_name | Phenotype |
| keywords[0].id | https://openalex.org/keywords/microglia |
| keywords[0].score | 0.8121544122695923 |
| keywords[0].display_name | Microglia |
| keywords[1].id | https://openalex.org/keywords/astrocyte |
| keywords[1].score | 0.7940303683280945 |
| keywords[1].display_name | Astrocyte |
| keywords[2].id | https://openalex.org/keywords/status-epilepticus |
| keywords[2].score | 0.7769399285316467 |
| keywords[2].display_name | Status epilepticus |
| keywords[3].id | https://openalex.org/keywords/biology |
| keywords[3].score | 0.6988902688026428 |
| keywords[3].display_name | Biology |
| keywords[4].id | https://openalex.org/keywords/complement |
| keywords[4].score | 0.6586259603500366 |
| keywords[4].display_name | Complement (music) |
| keywords[5].id | https://openalex.org/keywords/neuroscience |
| keywords[5].score | 0.6409859657287598 |
| keywords[5].display_name | Neuroscience |
| keywords[6].id | https://openalex.org/keywords/complement-system |
| keywords[6].score | 0.5463424921035767 |
| keywords[6].display_name | Complement system |
| keywords[7].id | https://openalex.org/keywords/immunology |
| keywords[7].score | 0.4773397743701935 |
| keywords[7].display_name | Immunology |
| keywords[8].id | https://openalex.org/keywords/alternative-complement-pathway |
| keywords[8].score | 0.4287509322166443 |
| keywords[8].display_name | Alternative complement pathway |
| keywords[9].id | https://openalex.org/keywords/central-nervous-system |
| keywords[9].score | 0.3351081609725952 |
| keywords[9].display_name | Central nervous system |
| keywords[10].id | https://openalex.org/keywords/epilepsy |
| keywords[10].score | 0.20566225051879883 |
| keywords[10].display_name | Epilepsy |
| keywords[11].id | https://openalex.org/keywords/inflammation |
| keywords[11].score | 0.19546523690223694 |
| keywords[11].display_name | Inflammation |
| keywords[12].id | https://openalex.org/keywords/immune-system |
| keywords[12].score | 0.1486382782459259 |
| keywords[12].display_name | Immune system |
| keywords[13].id | https://openalex.org/keywords/genetics |
| keywords[13].score | 0.09048593044281006 |
| keywords[13].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.1002/glia.23955 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S147407642 |
| locations[0].source.issn | 0894-1491, 1098-1136 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0894-1491 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Glia |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_lineage_names | Wiley |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Glia |
| locations[0].landing_page_url | https://doi.org/10.1002/glia.23955 |
| locations[1].id | pmid:33314324 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Glia |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/33314324 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:7936954 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Glia |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7936954 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5104005726 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-9342-0498 |
| authorships[0].author.display_name | Yujia Wei |
| authorships[0].countries | CN, US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I1330342723 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I4210117763 |
| authorships[0].affiliations[1].raw_affiliation_string | Department of Neurosurgery, Xinqiao Hospital, Army Military Medical University, Chongqing, China |
| authorships[0].institutions[0].id | https://openalex.org/I4210117763 |
| authorships[0].institutions[0].ror | https://ror.org/02d217z27 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210117763 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Xinqiao Hospital |
| authorships[0].institutions[1].id | https://openalex.org/I1330342723 |
| authorships[0].institutions[1].ror | https://ror.org/02qp3tb03 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I1330342723 |
| authorships[0].institutions[1].country_code | US |
| authorships[0].institutions[1].display_name | Mayo Clinic |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Yujia Wei |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA, Department of Neurosurgery, Xinqiao Hospital, Army Military Medical University, Chongqing, China |
| authorships[1].author.id | https://openalex.org/A5034818470 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-5717-5755 |
| authorships[1].author.display_name | Tingjun Chen |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1330342723 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[1].institutions[0].id | https://openalex.org/I1330342723 |
| authorships[1].institutions[0].ror | https://ror.org/02qp3tb03 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I1330342723 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Mayo Clinic |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Tingjun Chen |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[2].author.id | https://openalex.org/A5082170009 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-3982-5056 |
| authorships[2].author.display_name | Dale B. Bosco |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1330342723 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[2].institutions[0].id | https://openalex.org/I1330342723 |
| authorships[2].institutions[0].ror | https://ror.org/02qp3tb03 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I1330342723 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Mayo Clinic |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Dale B. Bosco |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[3].author.id | https://openalex.org/A5022533790 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-1747-1699 |
| authorships[3].author.display_name | Manling Xie |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1330342723 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[3].institutions[0].id | https://openalex.org/I1330342723 |
| authorships[3].institutions[0].ror | https://ror.org/02qp3tb03 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I1330342723 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Mayo Clinic |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Manling Xie |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[4].author.id | https://openalex.org/A5078154869 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-7457-6198 |
| authorships[4].author.display_name | Jiaying Zheng |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1330342723 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[4].institutions[0].id | https://openalex.org/I1330342723 |
| authorships[4].institutions[0].ror | https://ror.org/02qp3tb03 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I1330342723 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Mayo Clinic |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Jiaying Zheng |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[5].author.id | https://openalex.org/A5042444644 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-3289-1402 |
| authorships[5].author.display_name | Aastha Dheer |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I1330342723 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[5].institutions[0].id | https://openalex.org/I1330342723 |
| authorships[5].institutions[0].ror | https://ror.org/02qp3tb03 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I1330342723 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Mayo Clinic |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Aastha Dheer |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[6].author.id | https://openalex.org/A5069293053 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-6088-124X |
| authorships[6].author.display_name | Yanlu Ying |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I1330342723 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[6].institutions[0].id | https://openalex.org/I1330342723 |
| authorships[6].institutions[0].ror | https://ror.org/02qp3tb03 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I1330342723 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Mayo Clinic |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Yanlu Ying |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[7].author.id | https://openalex.org/A5100618196 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-3092-7598 |
| authorships[7].author.display_name | Qian Wu |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I1330342723 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[7].institutions[0].id | https://openalex.org/I1330342723 |
| authorships[7].institutions[0].ror | https://ror.org/02qp3tb03 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I1330342723 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | Mayo Clinic |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Qian Wu |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[8].author.id | https://openalex.org/A5055122406 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-1910-1576 |
| authorships[8].author.display_name | Vanda A. Lennon |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I1330342723 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I1330342723 |
| authorships[8].affiliations[1].raw_affiliation_string | Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[8].institutions[0].id | https://openalex.org/I1330342723 |
| authorships[8].institutions[0].ror | https://ror.org/02qp3tb03 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I1330342723 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Mayo Clinic |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Vanda A. Lennon |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[9].author.id | https://openalex.org/A5004035910 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-8019-3380 |
| authorships[9].author.display_name | Long‐Jun Wu |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I2801572250, https://openalex.org/I4210146710 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I1330342723 |
| authorships[9].affiliations[1].raw_affiliation_string | Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[9].affiliations[2].institution_ids | https://openalex.org/I1330342723 |
| authorships[9].affiliations[2].raw_affiliation_string | Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA |
| authorships[9].institutions[0].id | https://openalex.org/I2801572250 |
| authorships[9].institutions[0].ror | https://ror.org/03a9t7g49 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I2801572250 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | Jacksonville College |
| authorships[9].institutions[1].id | https://openalex.org/I1330342723 |
| authorships[9].institutions[1].ror | https://ror.org/02qp3tb03 |
| authorships[9].institutions[1].type | healthcare |
| authorships[9].institutions[1].lineage | https://openalex.org/I1330342723 |
| authorships[9].institutions[1].country_code | US |
| authorships[9].institutions[1].display_name | Mayo Clinic |
| authorships[9].institutions[2].id | https://openalex.org/I4210146710 |
| authorships[9].institutions[2].ror | https://ror.org/03zzw1w08 |
| authorships[9].institutions[2].type | healthcare |
| authorships[9].institutions[2].lineage | https://openalex.org/I1330342723, https://openalex.org/I4210146710 |
| authorships[9].institutions[2].country_code | US |
| authorships[9].institutions[2].display_name | Mayo Clinic in Florida |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | Long‐Jun Wu |
| authorships[9].is_corresponding | True |
| authorships[9].raw_affiliation_strings | Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7936954 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2020-12-21T00:00:00 |
| display_name | The complement |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11266 |
| primary_topic.field.id | https://openalex.org/fields/28 |
| primary_topic.field.display_name | Neuroscience |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2808 |
| primary_topic.subfield.display_name | Neurology |
| primary_topic.display_name | Neuroinflammation and Neurodegeneration Mechanisms |
| related_works | https://openalex.org/W3193914952, https://openalex.org/W2886765439, https://openalex.org/W2087951029, https://openalex.org/W2118103901, https://openalex.org/W2125850273, https://openalex.org/W1419933820, https://openalex.org/W2035494890, https://openalex.org/W4292833841, https://openalex.org/W2333388061, https://openalex.org/W2808717877 |
| cited_by_count | 125 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 39 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 29 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 31 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 18 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 8 |
| locations_count | 3 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:7936954 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | Glia |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7936954 |
| primary_location.id | doi:10.1002/glia.23955 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S147407642 |
| primary_location.source.issn | 0894-1491, 1098-1136 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0894-1491 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Glia |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_lineage_names | Wiley |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Glia |
| primary_location.landing_page_url | https://doi.org/10.1002/glia.23955 |
| publication_date | 2020-12-14 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W1990535528, https://openalex.org/W2557673464, https://openalex.org/W2008155801, https://openalex.org/W2147191089, https://openalex.org/W2127126677, https://openalex.org/W2809593454, https://openalex.org/W2698307513, https://openalex.org/W3036134455, https://openalex.org/W2092935640, https://openalex.org/W1990738990, https://openalex.org/W3014231726, https://openalex.org/W2104431737, https://openalex.org/W1991467703, https://openalex.org/W2165801811, https://openalex.org/W2401782172, https://openalex.org/W2008639289, https://openalex.org/W2933899143, https://openalex.org/W2346726077, https://openalex.org/W1978747157, https://openalex.org/W2515274402, https://openalex.org/W2059717761, https://openalex.org/W2038274440, https://openalex.org/W2168479296, https://openalex.org/W2700330585, https://openalex.org/W2572710398, https://openalex.org/W2899927624, https://openalex.org/W2022050193, https://openalex.org/W2916001803, https://openalex.org/W2079574859, https://openalex.org/W2103946141, https://openalex.org/W2343993944, https://openalex.org/W1984050978, https://openalex.org/W2560254576, https://openalex.org/W2033617297, https://openalex.org/W2090012338, https://openalex.org/W2766852629, https://openalex.org/W1993220836, https://openalex.org/W2083695557, https://openalex.org/W1906305879, https://openalex.org/W2085424855, https://openalex.org/W2074661552, https://openalex.org/W2802988332, https://openalex.org/W2345329114, https://openalex.org/W2911761011, https://openalex.org/W2735609145, https://openalex.org/W3044437879, https://openalex.org/W1980941036, https://openalex.org/W2509040111, https://openalex.org/W2178210969, https://openalex.org/W1993917927, https://openalex.org/W2622747611, https://openalex.org/W1995458780, https://openalex.org/W2982421381, https://openalex.org/W2054275187 |
| referenced_works_count | 54 |
| abstract_inverted_index.a | 3, 35, 133 |
| abstract_inverted_index.C3 | 82, 101 |
| abstract_inverted_index.It | 14 |
| abstract_inverted_index.be | 132 |
| abstract_inverted_index.by | 42, 122 |
| abstract_inverted_index.in | 26, 34, 60, 93 |
| abstract_inverted_index.is | 2, 15 |
| abstract_inverted_index.of | 6, 29, 38, 45, 51, 73, 109 |
| abstract_inverted_index.or | 18 |
| abstract_inverted_index.to | 78, 95, 119, 131 |
| abstract_inverted_index.we | 32 |
| abstract_inverted_index.C3. | 75 |
| abstract_inverted_index.CA3 | 63 |
| abstract_inverted_index.The | 111, 126 |
| abstract_inverted_index.and | 12, 24, 53, 55, 70, 84 |
| abstract_inverted_index.for | 137 |
| abstract_inverted_index.had | 88, 104 |
| abstract_inverted_index.how | 19 |
| abstract_inverted_index.may | 129 |
| abstract_inverted_index.the | 27, 61, 115 |
| abstract_inverted_index.C3aR | 85 |
| abstract_inverted_index.When | 76 |
| abstract_inverted_index.acid | 47 |
| abstract_inverted_index.both | 81 |
| abstract_inverted_index.less | 90, 106 |
| abstract_inverted_index.mice | 87, 103 |
| abstract_inverted_index.that | 8, 114 |
| abstract_inverted_index.(KA), | 48 |
| abstract_inverted_index.Here, | 31 |
| abstract_inverted_index.close | 57 |
| abstract_inverted_index.mice, | 80 |
| abstract_inverted_index.model | 37 |
| abstract_inverted_index.mouse | 36 |
| abstract_inverted_index.prove | 130 |
| abstract_inverted_index.their | 56, 71 |
| abstract_inverted_index.kainic | 46 |
| abstract_inverted_index.occurs | 21 |
| abstract_inverted_index.report | 33 |
| abstract_inverted_index.status | 39, 97 |
| abstract_inverted_index.target | 136 |
| abstract_inverted_index.Gliosis | 1 |
| abstract_inverted_index.between | 22 |
| abstract_inverted_index.induced | 41 |
| abstract_inverted_index.pathway | 117, 128 |
| abstract_inverted_index.reduced | 67 |
| abstract_inverted_index.region. | 64 |
| abstract_inverted_index.results | 112 |
| abstract_inverted_index.spatial | 58 |
| abstract_inverted_index.suggest | 113 |
| abstract_inverted_index.unclear | 16 |
| abstract_inverted_index.whether | 17 |
| abstract_inverted_index.−/− | 83, 86, 102 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.ablation | 66 |
| abstract_inverted_index.compared | 77 |
| abstract_inverted_index.epilepsy | 7, 138 |
| abstract_inverted_index.evidence | 108 |
| abstract_inverted_index.response | 94 |
| abstract_inverted_index.C3‐C3aR | 116, 127 |
| abstract_inverted_index.activated | 10 |
| abstract_inverted_index.astrocyte | 68 |
| abstract_inverted_index.comprises | 9 |
| abstract_inverted_index.crosstalk | 20 |
| abstract_inverted_index.epilepsy. | 30 |
| abstract_inverted_index.evolution | 28 |
| abstract_inverted_index.injection | 44 |
| abstract_inverted_index.mediating | 123 |
| abstract_inverted_index.microglia | 11, 23, 52 |
| abstract_inverted_index.potential | 134 |
| abstract_inverted_index.Microglial | 65 |
| abstract_inverted_index.activation | 50, 69 |
| abstract_inverted_index.astrocytes | 25, 54 |
| abstract_inverted_index.complement | 74 |
| abstract_inverted_index.sequential | 49 |
| abstract_inverted_index.treatment. | 139 |
| abstract_inverted_index.astrocytes. | 13 |
| abstract_inverted_index.contributes | 118 |
| abstract_inverted_index.hippocampal | 62 |
| abstract_inverted_index.interaction | 59, 92 |
| abstract_inverted_index.therapeutic | 135 |
| abstract_inverted_index.wild‐type | 79 |
| abstract_inverted_index.KA‐induced | 96, 120 |
| abstract_inverted_index.epilepticus, | 40 |
| abstract_inverted_index.epilepticus. | 98 |
| abstract_inverted_index.upregulation | 72 |
| abstract_inverted_index.Additionally, | 99 |
| abstract_inverted_index.KA‐injected | 100 |
| abstract_inverted_index.histochemical | 107 |
| abstract_inverted_index.significantly | 89, 105 |
| abstract_inverted_index.characteristic | 5 |
| abstract_inverted_index.communication. | 125 |
| abstract_inverted_index.histopathological | 4 |
| abstract_inverted_index.neurodegeneration | 121 |
| abstract_inverted_index.neurodegeneration. | 110 |
| abstract_inverted_index.microglia–astrocyte | 91, 124 |
| abstract_inverted_index.intracerebroventricular | 43 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 98 |
| corresponding_author_ids | https://openalex.org/A5004035910 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I1330342723, https://openalex.org/I2801572250, https://openalex.org/I4210146710 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7400000095367432 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.96537196 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |