The components of arginine and methylarginine metabolism are indicative of altered kidney function in intrauterine growth-restricted neonates Article Swipe
Lina Kleinebenne
,
Waldemar Röhrig
,
Fabian Ebach
,
Heiko Reutter
,
Alexander Pankraz
,
Katharina Monika Heuchel
,
Andreas Müller
,
Alina C. Hilger
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1097/hjh.0000000000003818
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1097/hjh.0000000000003818
Background: Intrauterine fetal growth restriction (IUGR) affects up to 10% of all pregnancies. Severe IUGR is associated with impaired kidney development, reduced nephron endowment, and chronic kidney disease later in life. Currently, no early predictive biomarker exists for detecting altered kidney function in neonates with IUGR. Because nephrons produce key enzymes for the metabolism of arginine and methylarginine components, we quantified and compared the concentrations of arginine and methylarginine metabolites between IUGR and non-IUGR neonates to identify potential biomarkers for the early detection of altered kidney function in IUGR neonates. Methods: Seventy-one IUGR and 123 non IUGR neonates were examined. Serum and Urine samples were obtained between 30 h and 5 days of life and between 5 and 70 days of life. Serum concentrations of creatinine, urea, symmetric and asymmetric-dimethylarginine metabolites (SDGV, SDMA, ADGV, and ADMA), guanidino-2-oxo-caproic acid (GOCA), citrulline, homocitrulline, arginine, and homoarginine were quantified using LC-MS/MS and standard clinical laboratory methods. Datasets were compared by Mann—Whitney--Wilcoxon or Chi-square tests for continuous and discrete parameters. P values were corrected for multiple comparisons using the Bonferroni method. Results: After Bonferroni correction, we found that serum creatinine, urea, SDGV, ADGV, and GOCA levels were significantly lower in neonates with IUGR. Consequently, the ratios of SDGV/SDMA, ADGV/ADMA, and GOCA/homoarginine were significantly lower in IUGR neonates. Conclusion: Our study suggests that arginine and methylarginine are possible early biomarkers for detecting altered kidney function in IUGR neonates.
Related Topics
Concepts
Medicine
Arginine
Intrauterine growth restriction
Kidney
Internal medicine
Renal function
Endocrinology
Nephron
Biomarker
Kidney disease
Fetus
Physiology
Pregnancy
Biology
Biochemistry
Genetics
Amino acid
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/hjh.0000000000003818
- OA Status
- hybrid
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401401228
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4401401228Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1097/hjh.0000000000003818Digital Object Identifier
- Title
-
The components of arginine and methylarginine metabolism are indicative of altered kidney function in intrauterine growth-restricted neonatesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-06Full publication date if available
- Authors
-
Lina Kleinebenne, Waldemar Röhrig, Fabian Ebach, Heiko Reutter, Alexander Pankraz, Katharina Monika Heuchel, Andreas Müller, Alina C. HilgerList of authors in order
- Landing page
-
https://doi.org/10.1097/hjh.0000000000003818Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1097/hjh.0000000000003818Direct OA link when available
- Concepts
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Medicine, Arginine, Intrauterine growth restriction, Kidney, Internal medicine, Renal function, Endocrinology, Nephron, Biomarker, Kidney disease, Fetus, Physiology, Pregnancy, Biology, Biochemistry, Genetics, Amino acidTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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40Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.LC-MS/MS | 147 |
| abstract_inverted_index.Methods: | 90 |
| abstract_inverted_index.Results: | 177 |
| abstract_inverted_index.arginine | 55, 66, 218 |
| abstract_inverted_index.clinical | 150 |
| abstract_inverted_index.compared | 62, 155 |
| abstract_inverted_index.discrete | 164 |
| abstract_inverted_index.function | 41, 86, 229 |
| abstract_inverted_index.identify | 76 |
| abstract_inverted_index.impaired | 18 |
| abstract_inverted_index.methods. | 152 |
| abstract_inverted_index.multiple | 171 |
| abstract_inverted_index.neonates | 43, 74, 97, 196 |
| abstract_inverted_index.nephrons | 47 |
| abstract_inverted_index.non-IUGR | 73 |
| abstract_inverted_index.obtained | 105 |
| abstract_inverted_index.possible | 222 |
| abstract_inverted_index.standard | 149 |
| abstract_inverted_index.suggests | 216 |
| abstract_inverted_index.arginine, | 141 |
| abstract_inverted_index.biomarker | 35 |
| abstract_inverted_index.corrected | 169 |
| abstract_inverted_index.detecting | 38, 226 |
| abstract_inverted_index.detection | 82 |
| abstract_inverted_index.examined. | 99 |
| abstract_inverted_index.neonates. | 89, 212, 232 |
| abstract_inverted_index.potential | 77 |
| abstract_inverted_index.symmetric | 127 |
| abstract_inverted_index.ADGV/ADMA, | 204 |
| abstract_inverted_index.Bonferroni | 175, 179 |
| abstract_inverted_index.Chi-square | 159 |
| abstract_inverted_index.Currently, | 31 |
| abstract_inverted_index.SDGV/SDMA, | 203 |
| abstract_inverted_index.associated | 16 |
| abstract_inverted_index.biomarkers | 78, 224 |
| abstract_inverted_index.continuous | 162 |
| abstract_inverted_index.endowment, | 23 |
| abstract_inverted_index.laboratory | 151 |
| abstract_inverted_index.metabolism | 53 |
| abstract_inverted_index.predictive | 34 |
| abstract_inverted_index.quantified | 60, 145 |
| abstract_inverted_index.Background: | 0 |
| abstract_inverted_index.Conclusion: | 213 |
| abstract_inverted_index.Seventy-one | 91 |
| abstract_inverted_index.citrulline, | 139 |
| abstract_inverted_index.comparisons | 172 |
| abstract_inverted_index.components, | 58 |
| abstract_inverted_index.correction, | 180 |
| abstract_inverted_index.creatinine, | 125, 185 |
| abstract_inverted_index.metabolites | 69, 130 |
| abstract_inverted_index.parameters. | 165 |
| abstract_inverted_index.restriction | 4 |
| abstract_inverted_index.Intrauterine | 1 |
| abstract_inverted_index.development, | 20 |
| abstract_inverted_index.homoarginine | 143 |
| abstract_inverted_index.pregnancies. | 12 |
| abstract_inverted_index.Consequently, | 199 |
| abstract_inverted_index.significantly | 193, 208 |
| abstract_inverted_index.concentrations | 64, 123 |
| abstract_inverted_index.methylarginine | 57, 68, 220 |
| abstract_inverted_index.homocitrulline, | 140 |
| abstract_inverted_index.GOCA/homoarginine | 206 |
| abstract_inverted_index.guanidino-2-oxo-caproic | 136 |
| abstract_inverted_index.Mann—Whitney--Wilcoxon | 157 |
| abstract_inverted_index.asymmetric-dimethylarginine | 129 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5018890899, https://openalex.org/A5065375120, https://openalex.org/A5106351040 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I2799391451, https://openalex.org/I4210098270 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5199999809265137 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.21054892 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |