The Contrasting Effects of Bothrops lanceolatus and Bothrops atrox Venom on Procoagulant Activity and Thrombus Stability under Blood Flow Conditions Article Swipe
Fatima Radouani
,
Prisca Jalta
,
Caroline Rapon
,
Chloe Lezin
,
Chelsea Branford
,
Jonathan Florentin
,
José Marı́a Gutiérrez
,
Dabor Résière
,
Rémi Nevière
,
Olivier Pierre-Louis
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/toxins16090400
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/toxins16090400
Background: Consumption coagulopathy and hemorrhagic syndrome are the typical features of Bothrops sp. snake envenoming. In contrast, B. lanceolatus envenoming can induce thrombotic complications. Our aim was to test whether crude B. lanceolatus and B. atrox venoms would display procoagulant activity and induce thrombus formation under flow conditions. Methods and Principal Findings: Fibrin formation in human plasma was observed for B. lanceolatus venom at 250–1000 ng/mL concentrations, which also induced clot formation in purified human fibrinogen, indicating thrombin-like activity. The degradation of fibrinogen confirmed the fibrinogenolytic activity of B. lanceolatus venom. B. lanceolatus venom displayed consistent thrombin-like and kallikrein-like activity increases in plasma conditions. The well-known procoagulant B. atrox venom activated plasmatic coagulation factors in vitro and induced firm thrombus formation under high shear rate conditions. In contrast, B. lanceolatus venom induced the formation of fragile thrombi that could not resist shear stress. Conclusions: Our results suggest that crude B. lanceolatus venom displays amidolytic activity and can activate the coagulation cascade, leading to prothrombin activation. B. lanceolatus venom induces the formation of an unstable thrombus under flow conditions, which can be prevented by the specific monovalent antivenom Bothrofav®.
Related Topics
Concepts
Bothrops
Venom
Bothrops jararaca
Blood flow
Antivenom
Biology
Ophidia
Snake venom
Medicine
Internal medicine
Ecology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/toxins16090400
- OA Status
- gold
- Cited By
- 4
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402598356
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4402598356Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/toxins16090400Digital Object Identifier
- Title
-
The Contrasting Effects of Bothrops lanceolatus and Bothrops atrox Venom on Procoagulant Activity and Thrombus Stability under Blood Flow ConditionsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-09-18Full publication date if available
- Authors
-
Fatima Radouani, Prisca Jalta, Caroline Rapon, Chloe Lezin, Chelsea Branford, Jonathan Florentin, José Marı́a Gutiérrez, Dabor Résière, Rémi Nevière, Olivier Pierre-LouisList of authors in order
- Landing page
-
https://doi.org/10.3390/toxins16090400Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3390/toxins16090400Direct OA link when available
- Concepts
-
Bothrops, Venom, Bothrops jararaca, Blood flow, Antivenom, Biology, Ophidia, Snake venom, Medicine, Internal medicine, EcologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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41Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.shear | 123, 141 |
| abstract_inverted_index.snake | 13 |
| abstract_inverted_index.under | 45, 121, 175 |
| abstract_inverted_index.venom | 62, 93, 109, 130, 151, 167 |
| abstract_inverted_index.vitro | 115 |
| abstract_inverted_index.which | 67, 178 |
| abstract_inverted_index.would | 37 |
| abstract_inverted_index.Fibrin | 52 |
| abstract_inverted_index.induce | 21, 42 |
| abstract_inverted_index.plasma | 56, 102 |
| abstract_inverted_index.resist | 140 |
| abstract_inverted_index.venom. | 90 |
| abstract_inverted_index.venoms | 36 |
| abstract_inverted_index.Methods | 48 |
| abstract_inverted_index.display | 38 |
| abstract_inverted_index.factors | 113 |
| abstract_inverted_index.fragile | 135 |
| abstract_inverted_index.induced | 69, 117, 131 |
| abstract_inverted_index.induces | 168 |
| abstract_inverted_index.leading | 161 |
| abstract_inverted_index.results | 145 |
| abstract_inverted_index.stress. | 142 |
| abstract_inverted_index.suggest | 146 |
| abstract_inverted_index.thrombi | 136 |
| abstract_inverted_index.typical | 8 |
| abstract_inverted_index.whether | 29 |
| abstract_inverted_index.Bothrops | 11 |
| abstract_inverted_index.activate | 157 |
| abstract_inverted_index.activity | 40, 86, 99, 154 |
| abstract_inverted_index.cascade, | 160 |
| abstract_inverted_index.displays | 152 |
| abstract_inverted_index.features | 9 |
| abstract_inverted_index.observed | 58 |
| abstract_inverted_index.purified | 73 |
| abstract_inverted_index.specific | 184 |
| abstract_inverted_index.syndrome | 5 |
| abstract_inverted_index.thrombus | 43, 119, 174 |
| abstract_inverted_index.unstable | 173 |
| abstract_inverted_index.Findings: | 51 |
| abstract_inverted_index.Principal | 50 |
| abstract_inverted_index.activated | 110 |
| abstract_inverted_index.activity. | 78 |
| abstract_inverted_index.antivenom | 186 |
| abstract_inverted_index.confirmed | 83 |
| abstract_inverted_index.contrast, | 16, 127 |
| abstract_inverted_index.displayed | 94 |
| abstract_inverted_index.formation | 44, 53, 71, 120, 133, 170 |
| abstract_inverted_index.increases | 100 |
| abstract_inverted_index.plasmatic | 111 |
| abstract_inverted_index.prevented | 181 |
| abstract_inverted_index.250–1000 | 64 |
| abstract_inverted_index.amidolytic | 153 |
| abstract_inverted_index.consistent | 95 |
| abstract_inverted_index.envenoming | 19 |
| abstract_inverted_index.fibrinogen | 82 |
| abstract_inverted_index.indicating | 76 |
| abstract_inverted_index.monovalent | 185 |
| abstract_inverted_index.thrombotic | 22 |
| abstract_inverted_index.well-known | 105 |
| abstract_inverted_index.Background: | 0 |
| abstract_inverted_index.Consumption | 1 |
| abstract_inverted_index.activation. | 164 |
| abstract_inverted_index.coagulation | 112, 159 |
| abstract_inverted_index.conditions, | 177 |
| abstract_inverted_index.conditions. | 47, 103, 125 |
| abstract_inverted_index.degradation | 80 |
| abstract_inverted_index.envenoming. | 14 |
| abstract_inverted_index.fibrinogen, | 75 |
| abstract_inverted_index.hemorrhagic | 4 |
| abstract_inverted_index.lanceolatus | 18, 32, 61, 89, 92, 129, 150, 166 |
| abstract_inverted_index.prothrombin | 163 |
| abstract_inverted_index.Bothrofav®. | 187 |
| abstract_inverted_index.Conclusions: | 143 |
| abstract_inverted_index.coagulopathy | 2 |
| abstract_inverted_index.procoagulant | 39, 106 |
| abstract_inverted_index.thrombin-like | 77, 96 |
| abstract_inverted_index.complications. | 23 |
| abstract_inverted_index.concentrations, | 66 |
| abstract_inverted_index.kallikrein-like | 98 |
| abstract_inverted_index.fibrinogenolytic | 85 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 10 |
| citation_normalized_percentile.value | 0.91100819 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |