The development status of PET radiotracers for evaluating neuroinflammation Article Swipe
Related Concepts
Neuroinflammation
Medicine
Translocator protein
Positron emission tomography
Radioligand
Neuroscience
Purinergic receptor
Pharmacology
Receptor
Nuclear medicine
Internal medicine
Inflammation
Biology
Namhun Lee
,
Jae Yong Choi
,
Young Hoon Ryu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s13139-023-00831-4
· OA: W4390669196
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s13139-023-00831-4
· OA: W4390669196
Neuroinflammation is associated with the pathophysiologies of neurodegenerative and psychiatric disorders. Evaluating neuroinflammation using positron emission tomography (PET) plays an important role in the early diagnosis and determination of proper treatment of brain diseases. To quantify neuroinflammatory responses in vivo, many PET tracers have been developed using translocator proteins, imidazole-2 binding site, cyclooxygenase, monoamine oxidase-B, adenosine, cannabinoid, purinergic P2X7, and CSF-1 receptors as biomarkers. In this review, we introduce the latest developments in PET tracers that can image neuroinflammation, focusing on clinical trials, and further consider their current implications.
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