The Dietary Inflammatory Index Is Not Associated With Gut Permeability or Biomarkers of Systemic Inflammation in HIV Immunologic Non-responders Article Swipe
Fat Malazogu
,
Rodney Rousseau
,
Nitin Shivappa
,
Sanja Huibner
,
Sharon Walmsley
,
Colin Kovacs
,
Erika Benko
,
Robert J. Reinhard
,
Ron Rosenes
,
James R. Hébert
,
Rupert Kaul
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fnut.2021.736816
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fnut.2021.736816
Immunologic non-responders (INRs) are a subset of individuals living with HIV who have suboptimal blood CD4+ T cell recovery despite effective antiretroviral therapy (ART). They are at an increased risk of serious non-AIDS co-morbidities and death, and demonstrate enhanced systemic immune activation. In other populations diet has been correlated with markers of systemic inflammation through the Diet Inflammatory Index (DII), but this association has not been studied in persons living with HIV (PLWH). Blood was collected from 28 INR PLWH with a blood CD4+ T cell count <350/μL despite ≥2 years of effective ART. Participants completed a Canadian Diet History Questionnaire, and their responses were used to calculate the DII. Plasma inflammatory markers (IFNγ, TNF, IL-6, sVCAM, D-dimer, sCD14 and CRP) were assayed by ELISA, cellular immune activation (HLA-DR and CD38 on CD4+ and CD8+ T cells) was quantified using flow cytometry, and small bowel permeability assessed by calculation of the urine LacMan ratio after drinking a mix of lactulose and mannitol. Participants were a median age of 57 years, had been on effective ART for 15 years, and the median DII was −1.91 (range of −3.78 to +2.23). No correlation was observed between DII and plasma markers of inflammation, levels of T cell activation, gut permeability, or the biomarker of bacterial translocation sCD14. Self-reported alcohol intake, a potential confounder of the relationship between diet and inflammatory biomarkers, was also not associated with systemic inflammation or gut permeability. Our findings suggest that other mechanisms, rather than diet, are likely to be the major driver of systemic inflammation in INR individuals.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnut.2021.736816
- https://www.frontiersin.org/articles/10.3389/fnut.2021.736816/pdf
- OA Status
- gold
- Cited By
- 3
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3217473708
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https://openalex.org/W3217473708Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fnut.2021.736816Digital Object Identifier
- Title
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The Dietary Inflammatory Index Is Not Associated With Gut Permeability or Biomarkers of Systemic Inflammation in HIV Immunologic Non-respondersWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-11-22Full publication date if available
- Authors
-
Fat Malazogu, Rodney Rousseau, Nitin Shivappa, Sanja Huibner, Sharon Walmsley, Colin Kovacs, Erika Benko, Robert J. Reinhard, Ron Rosenes, James R. Hébert, Rupert KaulList of authors in order
- Landing page
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https://doi.org/10.3389/fnut.2021.736816Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fnut.2021.736816/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fnut.2021.736816/pdfDirect OA link when available
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Systemic inflammation, Medicine, Immunology, Intestinal permeability, Inflammation, Immune system, Immune dysregulation, Biomarker, Internal medicine, Gastroenterology, Biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2025: 1, 2023: 2Per-year citation counts (last 5 years)
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52Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| citation_normalized_percentile.value | 0.68345037 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |