The different predictive effects of the intensity and proportion of CD20 expression on the prognosis of B‐lineage acute lymphocyte leukemia Article Swipe
Yun Tian
,
Xiaojiao Wang
,
Hao Ai
,
Xiaodong Lyu
,
Qian Wang
,
Xudong Wei
,
Yongping Song
,
Qingsong Yin
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/jha2.414
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/jha2.414
The prognostic effects of the CD20 positivity have been studied extensively in B‐lineage acute lymphocyte leukemia (B‐ALL) patients, but the results remain controversial. The aim of this study is to investigate the different predictive effects of the intensity and proportion of CD20 expression on the prognosis for B‐ALL patients by retrospective analysis. The mean fluorescence intensity (MFI) and percentage of CD20 on B‐ALL cells from 206 patients with B‐ALL were dynamically measured by flow cytometry, and their optimal cut‐off values were determined using the receiver operating characteristic curve. Changes in MFI and percentage of CD20 at various time points and their relationship with prognosis were analyzed. We found that a low baseline CD20 MFI or high CD20 proportion was significantly associated with shorter 5‐year overall survival and progression‐free survival, and the combination of these two factors could more accurately predict worse survival for B‐ALL patients. Furthermore, low CD20 MFI or a high CD20 proportion had different predictive effects for ALL patients with different clinical characteristics and could serve as an independent risk factor for adverse prognosis. There were significant decreases in both the intensity and proportion of CD20 after recurrence in the absence of rituximab treatment, particularly with CD20 intensity. Notably, the decrease of CD20 intensity after recurrence indicated a more shortened survival time. Finally, we conclude that a low intensity or high proportion of CD20 expression may be used as an indicator for inferior prognosis for B‐ALL patients. CD20 intensity is more likely to be a more universal biomarker for worse prognosis.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/jha2.414
- OA Status
- diamond
- Cited By
- 3
- References
- 34
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4220847141Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/jha2.414Digital Object Identifier
- Title
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The different predictive effects of the intensity and proportion of CD20 expression on the prognosis of B‐lineage acute lymphocyte leukemiaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-03-25Full publication date if available
- Authors
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Yun Tian, Xiaojiao Wang, Hao Ai, Xiaodong Lyu, Qian Wang, Xudong Wei, Yongping Song, Qingsong YinList of authors in order
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https://doi.org/10.1002/jha2.414Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
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https://doi.org/10.1002/jha2.414Direct OA link when available
- Concepts
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CD20, Medicine, Rituximab, Internal medicine, Intensity (physics), Receiver operating characteristic, Flow cytometry, Leukemia, Lymphocyte, Oncology, Immunology, Lymphoma, Quantum mechanics, PhysicsTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2024: 1, 2023: 1, 2022: 1Per-year citation counts (last 5 years)
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34Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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