The Drosophila Dead end Arf-like3 GTPase controls vesicle trafficking during tracheal fusion cell morphogenesis Article Swipe
Jiang Lan
,
Stephen L. Rogers
,
Stephen T. Crews
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.17615/57pq-5x98
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.17615/57pq-5x98
The Drosophila larval tracheal system consists of a highly branched tubular organ that becomes interconnected by migration-fusion events during embryonic development. Fusion cells at the tip of each branch guide migration, adhere, and then undergo extensive remodeling as the tracheal lumen extends between the two branches. The Drosophila dead end gene is expressed in fusion cells, and encodes an Arf-like3 GTPase. Analyses of dead end RNAi and mutant embryos reveals that the lumen fails to connect between the two branches. Expression of a constitutively active form of Dead end in S2 cells reveal that it influences the state of actin polymerization, and is present on particles that traffic along actin/microtubule-containing processes. Imaging experiments in vivo reveal that Dead end-containing vesicles are associated with recycling endosomes and the exocyst, and control exocyst localization in fusion cells. These results indicate that the Dead end GTPase plays an important role in trafficking membrane components involved in tracheal fusion cell morphogenesis and lumenal development.
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Metadata
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- article
- Language
- en
- Landing Page
- https://doi.org/10.17615/57pq-5x98
- OA Status
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- 3
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- 10
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4298108745Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.17615/57pq-5x98Digital Object Identifier
- Title
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The Drosophila Dead end Arf-like3 GTPase controls vesicle trafficking during tracheal fusion cell morphogenesisWork title
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articleOpenAlex work type
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enPrimary language
- Publication year
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2020Year of publication
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2020-11-02Full publication date if available
- Authors
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Jiang Lan, Stephen L. Rogers, Stephen T. CrewsList of authors in order
- Landing page
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https://doi.org/10.17615/57pq-5x98Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://doi.org/10.17615/57pq-5x98Direct OA link when available
- Concepts
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Cell biology, Morphogenesis, Vesicle, GTPase, Small GTPase, Biology, Signal transduction, Genetics, Gene, MembraneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
-
2012: 1Per-year citation counts (last 5 years)
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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