The effect of cannabis-derived terpenes on alveolar macrophage function Article Swipe
Patrick M Greiss
,
Jacquelyn D. Rich
,
Geoffrey A. McKay
,
Dao M. Nguyen
,
Mark Lefsrud
,
David H. Eidelman
,
Carolyn J. Baglole
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/ftox.2024.1504508
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/ftox.2024.1504508
Cannabis sativa (marijuana) is used by millions of people around the world. C. sativa produces hundreds of secondary metabolites including cannabinoids, flavones and terpenes. Terpenes are a broad class of organic compounds that give cannabis and other plants its aroma. Previous studies have demonstrated that terpenes may exert anti-inflammatory properties on immune cells. However, it is not known whether terpenes derived from cannabis alone or in combination with the cannabinoid ∆ 9 -THC impacts the function of alveolar macrophages, a specialized pulmonary innate immune cell that is important in host defense against pathogens. Therefore, we investigated the immunomodulatory properties of two commercially-available cannabis terpene mixtures on the function of MH-S cells, a murine alveolar macrophage cell line. MH-S cells were exposed to terpene mixtures at sublethal doses and to the bacterial product lipopolysaccharide (LPS). We measured inflammatory cytokine levels using qRT-PCR and multiplex ELISA, as well as phagocytosis of opsonized IgG-coated beads or mCherry-expressing Escherichia coli via flow cytometry. Neither terpene mixture affected inflammatory cytokine production by MH-S cells in response to LPS. Terpenes increased MH-S cell uptake of opsonized beads but had no effect on phagocytosis of E. coli . Addition of ∆ 9 -THC to terpenes did not potentiate cytotoxicity nor phagocytosis. These results suggest that terpenes from cannabis have minimal impact on the function of alveolar macrophages.
Related Topics
Concepts
Terpene
Cannabis
Alveolar macrophage
Macrophage
Function (biology)
Chemistry
Medicine
Biology
Cell biology
Psychiatry
Biochemistry
In vitro
Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.3389/ftox.2024.1504508
- OA Status
- gold
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407045806
All OpenAlex metadata
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https://openalex.org/W4407045806Canonical identifier for this work in OpenAlex
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https://doi.org/10.3389/ftox.2024.1504508Digital Object Identifier
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The effect of cannabis-derived terpenes on alveolar macrophage functionWork title
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articleOpenAlex work type
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enPrimary language
- Publication year
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2025Year of publication
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2025-01-31Full publication date if available
- Authors
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Patrick M Greiss, Jacquelyn D. Rich, Geoffrey A. McKay, Dao M. Nguyen, Mark Lefsrud, David H. Eidelman, Carolyn J. BagloleList of authors in order
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https://doi.org/10.3389/ftox.2024.1504508Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.3389/ftox.2024.1504508Direct OA link when available
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Terpene, Cannabis, Alveolar macrophage, Macrophage, Function (biology), Chemistry, Medicine, Biology, Cell biology, Psychiatry, Biochemistry, In vitroTop concepts (fields/topics) attached by OpenAlex
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