The effect of cisplatin-based neoadjuvant chemotherapy on the renal function of patients undergoing radical cystectomy Article Swipe
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· 2023
· Open Access
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· DOI: https://doi.org/10.5489/cuaj.8570
INTRODUCTION: Cisplatin-based neoadjuvant chemotherapy (NAC) is the standard of care for patients with muscle-invasive bladder cancer (MIBC) undergoing radical cystectomy (RC). Cisplatin, however, can induce renal toxicity. Furthermore, RC is an independent risk factor for renal injury, with decreases in estimated glomerular filtration rate (eGFR) of up to 6 mL/min/1.73 m2 reported at one year postoperatively. Our objective was to evaluate the effect of cisplatin-based NAC and RC on the renal function of patients undergoing both. METHODS: We analyzed a multicenter database of patients with MIBC, all of whom received cisplatin-based NAC prior to RC. eGFR values were collected at time points T1 (before NAC), T2 (after NAC but before RC), and T3 (one year post-RC). eGFR and proportion of patients with eGFR <60 ml/min/1.73m2 (chronic kidney disease [CKD] stage ≥3) were compared between these time points. As all patients in this dataset had received NAC, we identified a retrospective cohort of patients from one institution who had undergone RC during the same time period without NAC for context. RESULTS: We identified 234 patients with available renal function data. From T1 to T3, there was a mean decline in eGFR of 17% (13 mL/min/1.73 m2) in the NAC cohort and an increase in proportion of patients with stage ≥3 CKD from 27% to 50%. The parallel cohort of patients who did not receive NAC was comprised of 236 patients. The mean baseline eGFR in this cohort was lower than in the NAC cohort (66 vs. 75 mL/min/1.73 m2). The mean eGFR decline in this non-NAC cohort from T1 to T3 was 6% (4 mL/ min/1.73 m2), and the proportion of those with stage ≥3 CKD increased from 37% to 51%. CONCLUSIONS: Administration of NAC prior to RC was associated with a 17% decline in eGFR and a nearly doubled incidence of stage ≥3 CKD at one year after RC. Patients who underwent RC without NAC had a higher rate of stage ≥3 CKD at baseline but appeared to have less renal function loss at one year.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.5489/cuaj.8570
- https://cuaj.ca/index.php/journal/article/download/8570/5863
- OA Status
- diamond
- Cited By
- 5
- References
- 29
- Related Works
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- OpenAlex ID
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387341599Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.5489/cuaj.8570Digital Object Identifier
- Title
-
The effect of cisplatin-based neoadjuvant chemotherapy on the renal function of patients undergoing radical cystectomyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-10-03Full publication date if available
- Authors
-
Matthew D. Ho, Anna J. Black, Homayoun Zargar, Adrian Fairey, Laura S. Mertens, Colin P. Dinney, Maria Carmen Mir, Laura‐Maria Krabbe, Michael S. Cookson, Niels-Erik Jacobsen, Jeffrey S. Montgomery, Evan Y. Yu, Évanguelos Xylinas, Wassim Kassouf, Marc Dall’Era, Nikhil Vasdev, Srikala S. Sridhar, John S. McGrath, Jonathan Aning, Jeff M. Holzbeierlein, Andrew C. Thorpe, Shahrokh F. Shariat, Jonathan L. Wright, Todd M. Morgan, Trinity J. Bivalacqua, Scott North, Daniel A. Barocas, Yair Lotan, Petros Grivas, Andrew J. Stephenson, Jay B. Shah, Bas W. van Rhijn, Siamak Daneshmand, Philippe E. Spiess, Peter C. BlackList of authors in order
- Landing page
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https://doi.org/10.5489/cuaj.8570Publisher landing page
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https://cuaj.ca/index.php/journal/article/download/8570/5863Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://cuaj.ca/index.php/journal/article/download/8570/5863Direct OA link when available
- Concepts
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Medicine, Cystectomy, Renal function, Cohort, Bladder cancer, Cisplatin, Urology, Kidney disease, Retrospective cohort study, Internal medicine, Context (archaeology), Chemotherapy, Oncology, Surgery, Cancer, Biology, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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29Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.estimated | 40 |
| abstract_inverted_index.incidence | 299 |
| abstract_inverted_index.increased | 275 |
| abstract_inverted_index.objective | 57 |
| abstract_inverted_index.patients. | 228 |
| abstract_inverted_index.post-RC). | 115 |
| abstract_inverted_index.toxicity. | 26 |
| abstract_inverted_index.undergone | 158 |
| abstract_inverted_index.underwent | 311 |
| abstract_inverted_index.Cisplatin, | 21 |
| abstract_inverted_index.associated | 288 |
| abstract_inverted_index.cystectomy | 19 |
| abstract_inverted_index.filtration | 42 |
| abstract_inverted_index.glomerular | 41 |
| abstract_inverted_index.identified | 147, 171 |
| abstract_inverted_index.proportion | 118, 203, 268 |
| abstract_inverted_index.undergoing | 17, 74 |
| abstract_inverted_index.independent | 31 |
| abstract_inverted_index.institution | 155 |
| abstract_inverted_index.mL/min/1.73 | 49, 193, 246 |
| abstract_inverted_index.multicenter | 80 |
| abstract_inverted_index.neoadjuvant | 2 |
| abstract_inverted_index.CONCLUSIONS: | 280 |
| abstract_inverted_index.Furthermore, | 27 |
| abstract_inverted_index.chemotherapy | 3 |
| abstract_inverted_index.INTRODUCTION: | 0 |
| abstract_inverted_index.ml/min/1.73m2 | 124 |
| abstract_inverted_index.retrospective | 149 |
| abstract_inverted_index.Administration | 281 |
| abstract_inverted_index.Cisplatin-based | 1 |
| abstract_inverted_index.cisplatin-based | 64, 90 |
| abstract_inverted_index.muscle-invasive | 13 |
| abstract_inverted_index.postoperatively. | 55 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 7 |
| institutions_distinct_count | 35 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.85737446 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |