The effect of cognitive dysfunction on mid- and long-term mortality after vascular surgery Article Swipe
András Szabó
,
Krisztina Tóth
,
Ádám Nagy
,
Dominika Domokos
,
Nikoletta Ráhel Czobor
,
Csaba Eke
,
Ágnes Dóra Sándor
,
Béla Merkely
,
Éva Susánszky
,
János Gál
,
Andrea Székely
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-42677/v2
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-42677/v2
Background: In recent decades, previous studies have noted the importance of frailty, which is a frequently used term in perioperative risk evaluations. Psychological and socioeconomical domains were investigated as part of frailty syndrome. The aim of this study was to assess the importance of these factors in mortality after vascular surgery.Methods: In our prospective, observational study (ClinicalTrials.gov Identifier: NCT02224222), we examined 164 patients who underwent elective vascular surgery between 2014 and 2017. At the outpatient anaesthesiology clinic, patients completed a questionnaire about cognitive functions, depression and anxiety, social support and self-reported quality of life were assessed using a comprehensive frailty index, in addition to medical variables. Propensity score matching was performed to analyse the difference between patients and controls in a nationwide population cohort. The primary outcome was 4 year mortality. The Kaplan-Meier method and Cox regression analysis were used for statistical analyses.Results: The patients’ mean age was 67.05 years (SD: 9.49 years). Mini-Mental State Examination scores of less than 27 points were recorded for 41 patients. Overall mortality rates were 22.4% and 47.6% in the control and cognitive impairment groups, respectively (p=0.013). In the univariate Cox regression analysis, cognitive impairment measured using age- and education-adjusted MMSE scores increased the risk of mortality (AHR: 2.842, 95% CI: 1.389-5.815, p=0.004).Conclusion: Even mild cognitive dysfunction measured preoperatively using the MMSE represents a potentially important risk factor for mortality after vascular surgery.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-42677/v2
- https://www.researchsquare.com/article/rs-42677/v2.pdf?c=1631881237000
- OA Status
- gold
- Cited By
- 2
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4230610264
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4230610264Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-42677/v2Digital Object Identifier
- Title
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The effect of cognitive dysfunction on mid- and long-term mortality after vascular surgeryWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-12-14Full publication date if available
- Authors
-
András Szabó, Krisztina Tóth, Ádám Nagy, Dominika Domokos, Nikoletta Ráhel Czobor, Csaba Eke, Ágnes Dóra Sándor, Béla Merkely, Éva Susánszky, János Gál, Andrea SzékelyList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-42677/v2Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-42677/v2.pdf?c=1631881237000Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-42677/v2.pdf?c=1631881237000Direct OA link when available
- Concepts
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Term (time), Cognition, Postoperative cognitive dysfunction, Medicine, Vascular surgery, Psychology, Surgery, Psychiatry, Cardiac surgery, Physics, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
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-
2Total citation count in OpenAlex
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2022: 1, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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51Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| publication_date | 2020-12-14 |
| publication_year | 2020 |
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