The Effect of Iron Oxide Nanoparticles on the Menaquinone-7 Isomer Composition and Synthesis of the Biologically Significant All-Trans Isomer Article Swipe
Neha Lal
,
Mostafa Seifan
,
Alireza Ebrahiminezhad
,
Aydin Berenjian
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/nano13121825
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/nano13121825
Menaquinone-7 (MK-7) is the most therapeutically valuable K vitamin owing to its excellent bioavailability. MK-7 occurs as geometric isomers, and only all-trans MK-7 is bioactive. The fermentation-based synthesis of MK-7 entails various challenges, primarily the low fermentation yield and numerous downstream processing steps. This raises the cost of production and translates to an expensive final product that is not widely accessible. Iron oxide nanoparticles (IONPs) can potentially overcome these obstacles due to their ability to enhance fermentation productivity and enable process intensification. Nevertheless, utilisation of IONPs in this regard is only beneficial if the biologically active isomer is achieved in the greatest proportion, the investigation of which constituted the objective of this study. IONPs (Fe3O4) with an average size of 11 nm were synthesised and characterised using different analytical techniques, and their effect on isomer production and bacterial growth was assessed. The optimum IONP concentration (300 μg/mL) improved the process output and resulted in a 1.6-fold increase in the all-trans isomer yield compared to the control. This investigation was the first to evaluate the role of IONPs in the synthesis of MK-7 isomers, and its outcomes will assist the development of an efficient fermentation system that favours the production of bioactive MK-7.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/nano13121825
- https://www.mdpi.com/2079-4991/13/12/1825/pdf?version=1687160574
- OA Status
- gold
- Cited By
- 6
- References
- 80
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4380089552
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4380089552Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/nano13121825Digital Object Identifier
- Title
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The Effect of Iron Oxide Nanoparticles on the Menaquinone-7 Isomer Composition and Synthesis of the Biologically Significant All-Trans IsomerWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-06-08Full publication date if available
- Authors
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Neha Lal, Mostafa Seifan, Alireza Ebrahiminezhad, Aydin BerenjianList of authors in order
- Landing page
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https://doi.org/10.3390/nano13121825Publisher landing page
- PDF URL
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https://www.mdpi.com/2079-4991/13/12/1825/pdf?version=1687160574Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.mdpi.com/2079-4991/13/12/1825/pdf?version=1687160574Direct OA link when available
- Concepts
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Yield (engineering), Fermentation, Bioavailability, Iron oxide nanoparticles, Chemistry, Nanoparticle, Composition (language), Combinatorial chemistry, Food science, Nanotechnology, Iron oxide, Organic chemistry, Materials science, Biology, Bioinformatics, Linguistics, Metallurgy, PhilosophyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1, 2023: 4Per-year citation counts (last 5 years)
- References (count)
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80Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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